"Effect of Clozapine on Appetite, Weight and Insulin Resistance in Schizophrenia Patient in Mental Health Psychiatry Outpatient Clinics KFSH&RC (Case Report)"

Abstract

Background: Schizophrenia is a psychotic disorder with a complex pathophysiology and requires treatment that includes long term administration of antipsychotics that is said to be associated with metabolic syndrome.Objective: To estimate the prevalence of metabolic syndrome in patients taken clozapine at King Faisal Specialist Hospital &Research Centre, Outpatient clinics.Methods: This study was conducted at outpatient setting, KFSH&RC. Total patients included in this study are 39 patients. All patients were on maintenance dose of clozapine therapy. Measurement of anthropometric (body weight (BMI), waist circumference, blood pressure) and biochemical parameters (glucose, insulin, triglycerides, LDL, HDL) were recorded, Data analyses were collected during their regular follow-ups. Result:The prevalence of the metabolic syndrome was significantly higher among clozapine patients according to all literature but in this study 3 patients out of 39 were affected. The analysis revealed significant associations with age, body mass index, and duration of clozapine medication & family history. This finding is consistent with literature about associated with clozapine& mentioned risk factor. Our three affected patients had the following result.