Effect of clonidine on cardiac acceleration in vagotomized dogs

Effect of clonidine on cardiac acceleration in pithed rats

“…The results are in general agreement with those found by other workers (Armstrong & Boura, 1973;Scriabine & Stavorski, 1973;Scriabine & others 1970;Pacha, Salzmann & Scholtysik 1975) but are at variance with those of Antonaccio & Robson (1973) in that they support the hypothesis that sympathetic nerves are under functionally significant feedback control mediated by a-receptors.…”

“…Antonaccio & Robson (1973) examined the effects of clonidine in dogs and concluded that the inhibition of cardiac acceleration was the result of increased vagal activity. Scriabine & Stavorski (1973) however concluded that clonidine-induced antagonism of cardiac acceleration could not be explained by enhancement of vagal activity alone since clonidine was effective after bilateral vagotomy.…”

The Pharmacology of Clonidine and Related Products

“…Therefore the activation of the vagal tone appears to be involved in this effect. But in KOBINGER'S (1967) experiment in cats such an effect was not found and SCRIABINE und STAVORSKI (1973) were also unable to repeat ANTONAC-CIO and ROBSON's results in dogs.…”

Sixth Gaddum Memorial Lecture National Institute for Medical Research, Mill Hill, January 1977

“…The frequency-dependence of the inhibition of noradrenaline release obtained with clonidine was also demonstrated under in vivo conditions in the rat (Armstrong & Boura, 1973) and in the dog (Scriabine & Stavorski, 1973;Robson & Antonaccio, 1974;Yamaguchi, de Champlain & Nadeau, 1977).…”