Effect of Clomiphene on Rat Zygotes

Davidson, O. W.; Schuchner, Elsa B.; Wada, Kyoko

doi:10.1016/s0015-0282(16)35648-5

“…The compounds include a group synthesized by the Merrell Company (MER-25 and clomi¬ phene, MRL-41) and a group produced by the Upjohn Company (U-l 1555A, U-10520A and U-11100A). Most of the investigations have involved the antifertility effects of injected or oral doses during the first few days of pregnancy in the rat (Barnes & Meyer, 1962;Davidson, Schuckner & Wada, 1965;Duncan, Stucki, Lyster & Lednicer, 1962;Nelson, Davidson & Wada, 1963;Segal & Nelson, 1961). During this period the zygotes are undergoing cleavage and blastocyst formation, while being transported through the oviduct to the uterus, in preparation for implantation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Two Non-Steroidal Antifertility Agents on Pregnancy in Mice

Thomson¹

1968

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Summary. The antifertility effects of two non-steroidal compounds, clomiphene and a diphenylindene derivative (U-11555A), were studied in the mouse, using two different methods. First, the effects of various concentrations of the compounds on the in-vitro development of two-cell mouse embryos into blastocysts were investigated. Second, the oral doses of the compounds which were necessary to block pregnancy in mice were determined. It was found that the inhibitory doses for mice are somewhat higher than for rats. Although it is impossible to make direct comparisons between the effective in-vivo and in-vitro doses, the inhibitory concentrations seem to be of nearly the same order in both cases.

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“…[212][213][214] Inhibition of uterine implantation, diminished fetal survival, and a blastocytotoxic effect have also been described. [215][216][217][218][219][220][221][222][223][224][225][226][227][228][229][230][231] However, of 58 infants with birth defects reported to Merrell National Laboratories, 8 were born to 7 of 15 mothers who received an inadvertent course of clomiphene citrate during the first 6 weeks after conception. 197 Thus, aside from sporadic and otherwise inadvertent administration during pregnancy, the usual preconceptional administration of clomiphene citrate in humans and its clearance kinetics would seem to make gestational exposure unlikely.…”

Section: Studying a Total Of 2369 Births Merrell Nationalmentioning

confidence: 99%

Clomiphene Citrate-Initiated Ovulation: A Clinical Update

Adashi¹

1986

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“…The compounds include a group synthesized by the Merrell Company (MER-25 and clomi¬ phene, MRL-41) and a group produced by the Upjohn Company (U-l 1555A, U-10520A and U-11100A). Most of the investigations have involved the antifertility effects of injected or oral doses during the first few days of pregnancy in the rat (Barnes & Meyer, 1962;Davidson, Schuckner & Wada, 1965;Duncan, Stucki, Lyster & Lednicer, 1962;Nelson, Davidson & Wada, 1963;Segal & Nelson, 1961). During this period the zygotes are undergoing cleavage and blastocyst formation, while being transported through the oviduct to the uterus, in preparation for implantation.…”

Section: Introductionmentioning

confidence: 99%

Effect of Two Non-Steroidal Antifertility Agents on Pregnancy in Mice

Jl¹

1968

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Summary. The antifertility effects of two non-steroidal compounds, clomiphene and a diphenylindene derivative (U-11555A), were studied in the mouse, using two different methods. First, the effects of various concentrations of the compounds on the in-vitro development of two-cell mouse embryos into blastocysts were investigated. Second, the oral doses of the compounds which were necessary to block pregnancy in mice were determined. It was found that the inhibitory doses for mice are somewhat higher than for rats. Although it is impossible to make direct comparisons between the effective in-vivo and in-vitro doses, the inhibitory concentrations seem to be of nearly the same order in both cases.

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Effect of Clomiphene on Rat Zygotes

Cited by 22 publications

References 7 publications

Effect of Two Non-Steroidal Antifertility Agents on Pregnancy in Mice

Effect of Two Non-Steroidal Antifertility Agents on Pregnancy in Mice

Clomiphene Citrate-Initiated Ovulation: A Clinical Update

Effect of Two Non-Steroidal Antifertility Agents on Pregnancy in Mice

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