Effect of clomiphene citrate on ovulation after treatment withdrawal

Abstract

The effect of clomiphene citrate (CC) on ovarian function in cycles subsequent to treatment withdrawal was studied. Thirty two out of 45 patients with anovulation due to polycystic ovarian syndrome (PCOS) and with no other factor affecting fertility who got pregnant were included. All patients received CC to induce ovulation. Pregnancies in CC treated cycles and after treatment were recorded. Twenty pregnancies were achieved during CC treated cycles and 12 in the cycles after it was withdrawn. In the latter group, eight pregnancies were achieved in the cycle following CC therapy, and four in the second subsequent cycle. In relation to pregnancy complications no significant statistical differences were found between the group of patients who became pregnant during the stimulation cycles and in the cycles after CC.

Factor Ovárico Endocrino

“…Con este tratamiento, se logra ovulación en 87% de las pacientes y embarazo en 58% de los casos (10) . No obstante la gran experiencia en el uso del clomifeno, todavía existen aspectos poco conocidos, como su acción residual en ciclos posteriores a su administración, donde parece conservar su potencial inductor (11) . Otra forma para inducir la ovulación es la administración de metformina (1 000 a 1 500 mg por día), logrando ciclos ovulatorios en 50% de los casos.…”