Effect of Clomiphene Citrate on Plasma Levels of Immunoreactive Luteinizing Hormone-Releasing Hormone, Gonadotropin, and Testosterone in Normal Subjects and in Patients With Idiopathic Oligospermia

Masala, A.; Delitala, G.; Alagna, S.; Devilla, L.; Lotti, G

doi:10.1016/s0015-0282(16)43217-6

Cited by 20 publications

(6 citation statements)

References 10 publications

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“…This hypothesis is supported by the recent report of Másala et al (1978), who demonstrated a significant elevation of the plasma immunoreactive LRH in adult male subjects following clomiphene citrate administra¬ tion.…”

Section: Discussionsupporting

confidence: 63%

Acceleration of puberty in boys with delayed puberty by clomiphene citrate. A clinical and laboratory study

Dickerman¹,

Prager-Lewin²,

Lahmy³

et al. 1980

Acta Endocrinologica

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Clomiphene citrate was administered at a dose of 50 mg/day for 3 months to 29 boys with delayed puberty, 15 in a stage of early puberty (group 1) and 14 in stages of mid puberty (group 2). In both groups a significant acceleration in the advancement of pubertal signs was noted in the 6-month period following initiation of therapy as compared to a non-treated control group. A significant rise in the mean (\m=+-\SD) basal plasma LH levels, from 1.0 \m=+-\0.4 to 2.7 \ m=+-\2.2 mU/ml in group 1 (P< 0.05) and from 1.0 \ m=+-\0.6 to 2.2 \m=+-\1.7 mU/ml in group 2 (P < 0.05) was observed following the treatment period with clomiphene. Concomitantly there was a rise of the mean basal plasma FSH level from 1.1 \m=+-\0.4 to 2.0 \m=+-\1.5 mU/ml in group I (P \ m=+-\0.05) and from 1.9 \ m=+-\ 1.6 to 3.4 \m=+-\3.0 mU/ml in group 2 (P <0.02). The mean LH peak response to an iv bolus of LRH (50 \g=m\g/m2 iv) rose from 8.3 \m=+-\4.2 to 13.0 \m=+-\5.3 mU/ml in group 1 (P < 0.05) and from 9.2 \ m=+-\5.8 to 12.6 \ m=+-\6.8 mU/ml in group 2 (NS). The mean peak plasma FSH response to LRH rose from 2.0 \ m=+-\0.6 to 5.9 \ m=+-\4.2 mU/ml in group 1 (P < 0.05) and from 4.3 \ m=+-\ 4.0 to 7.0 \ m=+-\ 6.8 mU/ml in group 2 (NS).Clomiphene therapy caused a rise of the basal plasma testosterone level from 68 \ m=+-\53 to 313 \m=+-\270 ng/100 ml in group 1 (P <0.01) and from 103 \ m=+-\67 to 392 \ m=+-\248 ng/100 ml in group 2 (P< 0.01). The plasma testosterone response to one hCG stimulation (5000 U im), tested in 4 boys immediately before and after the 3-month period of clomiphene administration revealed an increase in both the basal and the peak testosterone levels (P < 0.05 and P< 0.001, respectively). A standard clomiphene test consisting of the administration of 100\p=n-\200 mg/day clomiphene citrate for 8 days was performed in 8 boys before initiation of clomiphene treatment for the 3-month period. In 4, including 2 boys in an early stage of puberty, there was a suppression of the basal level of gonadotrophins and their response to synthetic LRH. The other 4 boys, all of them in stages of mid-puberty, showed an increase in the basal and peak plasma gonadotrophin levels following LRH stimulation. In all 8 boys there was a significant rise of the basal plasma testosterone level. Despite the varying response to the short clomiphene test in these 8 boys, all gave a good response to the prolonged administration of clomiphene citrate. It was concluded that treatment with small doses of clomiphene citrate for a period of 3 months induces an acceleration of puberty in boys with delayed or slowlyprogressing puberty, once the stage of initiation of puberty has been passed.Delayed puberty in boys is one of the frequent causes for referral to our Insitute, and among the various aetiologies of delayed puberty in boys 'con¬ stitutional' delayed puberty is the most common (Root 1973). The introduction of sensitive radio¬ immunoassay (RIA) methods for the measurement of plasma gonadotrophins and testosterone levels and the availability of synthetic LR...

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Section: Discussionsupporting

confidence: 63%

Acceleration of puberty in boys with delayed puberty by clomiphene citrate. A clinical and laboratory study

Dickerman¹,

Prager-Lewin²,

Lahmy³

et al. 1980

Acta Endocrinologica

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“…[12] In other study indicates that there were no significant differences in FSH, LH and T levels between patients with idiopathic oligospermia and control during CC treatment. [13] Whereas, previous study recorded highly significant increase in FSH, LH and T levels during CC 50mg/day treatment in preselected infertile men for 3 months. [14] Also 10 oligozoospermic men treated with CC were showed significant increase in FSH, LH and T levels as an CC effect on sex hormone binding globulin in normospermic and oligozoospermic men study.…”

Section: World Journal Of Pharmacy and Pharmaceutical Sciencesmentioning

confidence: 86%

Effect of Clomiphene Citrate on Gonadotropin Hormones Fsh, Lh and Testosterone Levels in Mice Offspring

Henawi¹

2017

WJPPS

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“…It has been reported that hyperprolactinaemia has an inhibitory effect on the hypothalamic-pituitary-testicular axis in male patients with prolactinoma (Faglia et al, 1977;Bernini et al, 1983). On the contrary, stimulatory effect on the testicular function has been reported in su!piride-induced hyperprolactinaemia (Thorner et al, 1974;Ambrosi et al, 1976;Magrini et al, 1976;Faglia et al, 1977;Masala et al, 1978). The discrepancy might be due to the duration of the period of hyperprolactinaemia and the serum level of PRL.…”

Section: Discussionmentioning

confidence: 99%

“…In the present study, the serum PRL levels were elevated significantly (above 50 ng/ml) following daily oral administration of 150 mg sulpiride for 14 days. Other investigators also obtained plasma PRL levels of 32 (Ambrosi et al, 1976), 33 (Faglia et al, 1977), 61 ng/ml (Masala et al, 1978), using 150 mg sulpiride. Sulpiride was selected because it is a potent and long-acting prolactin releaser (Mancini et al, 1976), the site of action of sulpirides seems to be hypothalamic and/or pituitary by exerting a dopamine receptor blocking activity (MacLeod and Robyn, 1977), and because it was reported that sulpiride did not affect circulating levels of LII, FSII, thyroid-stimulating hormone (TSII), growth hormone (GH) or corticosteroids (L'Hermite et al, 1975).…”

Section: Discussionmentioning

confidence: 99%

“…To date, little is known about the testicular response to endogenous gonadotrophin stimulation during or after LHRII administration. The testosterone responses to human chorionic gonadotrophin (hCG) have been reported to be low (Thorner et al, 1974), normal (Carter et al, 1978) or high (Ambrosi et al, 1976;Margini et al, 1976;Faglia et al, 1977;Masala et al, 1978). Thus, the results reported are controversial.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pituitary and Testicular Response to Luteinizing Hormone Releasing Hormone in Normal and Sulpiride-Induced Hyperprolactinaemic Men

Nakano¹,

Yagi²,

Nishi³

2009

Exp Clin Endocrinol Diabetes

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Pituitary and testicular response to an intravenous infusion of 480 micrograms luteinizing hormone releasing hormone (LHRH) for 8 hours (1 microgram/min) was investigated in 8 male volunteers in normal and hyperprolactinaemic state. Eight normal men were given 150 mg of sulpiride daily for 14 days. Serum prolactin (PRL) levels were elevated significantly, but basal serum levels of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) did not change following daily oral administration of sulpiride in 8 normal men. Eight men showed biphasic LH response to LHRH infusion in both normal and hyperprolactinaemic state, and there was a rather exaggerated response in serum LH concentration in hyperprolactinaemic state. Serum FSH response to LHRH was similar in normal and hyperprolactinaemic state. Although slight increase in serum testosterone concentration was observed during LHRH infusion in normal and hyperprolactinaemic state, the statistical difference was not significant. The result of the present study suggests that the function of the hypothalamic-pituitary-testicular axis, as measured by serum gonadotrophin and testosterone responses, is well reserved.

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Effect of Clomiphene Citrate on Plasma Levels of Immunoreactive Luteinizing Hormone-Releasing Hormone, Gonadotropin, and Testosterone in Normal Subjects and in Patients With Idiopathic Oligospermia

Cited by 20 publications

References 10 publications

Acceleration of puberty in boys with delayed puberty by clomiphene citrate. A clinical and laboratory study

Acceleration of puberty in boys with delayed puberty by clomiphene citrate. A clinical and laboratory study

Effect of Clomiphene Citrate on Gonadotropin Hormones Fsh, Lh and Testosterone Levels in Mice Offspring

Pituitary and Testicular Response to Luteinizing Hormone Releasing Hormone in Normal and Sulpiride-Induced Hyperprolactinaemic Men

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