Effect of Clomiphene Citrate on Spermatogenesis in the Human

Jungck, Edwin C.; Roy, Somnath; Greenblatt, Robert B.; Mahest, Virendra B.

doi:10.1097/00006254-196406000-00033

Cited by 4 publications

(4 citation statements)

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“…It was then postulated that CC could assist with induction of ovulation and the first human trials were subsequently reported 1961 [60]. Shortly after this, CC use was tested in male subjects and was found to elevate both gonadotropins and SA parameters in oligospermic men [61,62]. CC has since become the most prescribed drug in the field of infertility.…”

Section: Clomiphene Citrate and Tamoxifenmentioning

confidence: 99%

Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Tatem

Beilan

Kovac³

et al. 2020

World J Mens Health

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There is often inherent conflict in the overlapping fields of male fertility and andrology. While the goal of all male fertility specialists is to facilitate and preserve biologic paternity, many practitioners also care for a significant number of patients suffering from hypogonadism. Exogenous testosterone administration, the gold standard for the management of these patients, almost universally impairs spermatogenesis and can even completely eradicate it in some men. With steady increases in both the incidence of hypogonadism and average paternal age, practitioners are now encountering hypogonadal men who desire future fertility or men suffering the effects of earlier androgenic anabolic steroid use with increasing frequency. In this manuscript, we review management strategies for these complex patients and explore novel medications that may be of use in this population.

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Section: Clomiphene Citrate and Tamoxifenmentioning

confidence: 99%

Management of Anabolic Steroid-Induced Infertility: Novel Strategies for Fertility Maintenance and Recovery

Tatem

Beilan

Kovac³

et al. 2020

World J Mens Health

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“…Systematic analysis and Cochrane review results also have failed to support the use of CC for empiric medical therapy, specifically for men with oligoasthenoteratozoospermia (69,70). Publications on the empiric use of CC date back to the mid-1960s, and there is a reason no consensus has been reached on its efficacy: it simply does not work (71).…”

Section: Empiric Medical Therapymentioning

confidence: 99%

Should empiric therapies be used for male factor infertility?

Chan

Kathrins

Showell

et al. 2020

Fertility and Sterility

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“…In males, urinary 17-keto-steroids (Harkness et al, 1964) and testosterone (Harkness, Loraine, Bell & Ismail, 1965) (Jungck, Roy, Greenblatt & Mahesh, 1964;Mellinger & Thompson, 1966;Potts, 1968); the different dosages and the duration of treatment and of follow-up may ex¬ plain some of the apparent discrepancies (Heller, Rowley & Heller, 1969 It is possible that the dose of clomiphene used in the study reported here was too high and also that the duration of the courses of treatment was too short; the time interval for a possible alteration in the function of the germinal epithelium to be reflected in the ejaculate is known to be at least 60 and up to as long as 90 days (Heller et al, 1969).…”

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confidence: 99%