Effect of clinicopathologic features on survival of patients with thymic carcinomas and thymic neuroendocrine tumors: A population-based analysis

Song, Qing; Zhang, Lan-Lin; Yuan, Quan; Xing, Kailin; Wu, Xianghua

doi:10.1016/j.currproblcancer.2019.03.004

Cited by 8 publications

(7 citation statements)

References 16 publications

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“…10 Kim et al also revealed that tumor size affects the prognosis of thymic epithelial tumors, 10 and studies of thymic carcinoma have also indicated that tumor size has prognostic value. 24-26 These results agree with our finding that tumor size was related to CSS.…”

Section: Discussionsupporting

confidence: 91%

Nomogram predicts the prognosis of patients with thymic carcinoma: A population-based study using SEER data

Huang

Liang

et al. 2022

Tumori

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Background: Thymic carcinoma (TC) is a rare malignant tumor that can have a poor prognosis, and accurate prognostication prediction remains difficult. We aimed to develop a nomogram to predict overall survival (OS) and cancer-specific survival (CSS) based on a large cohort of patients. Methods: The Surveillance Epidemiology and End Results (SEER) database was searched to identify TC patients (1975–2016). Univariate and multivariable Cox regression analyses were used to identify predictors of OS and CSS, which were used to construct nomograms. The nomograms were evaluated using the concordance index (C-index), calibration curve, receiver operating characteristic curve, and decision curve analysis (DCA). Subgroup analysis was performed to identify high-risk patients. Results: The analysis identified six predictors of OS (Masaoka stage, surgical method, lymph node metastasis, liver metastasis, bone metastasis, and radiotherapy) and five predictors of CSS (Masaoka stage, surgical method, lymph node metastasis, tumor size, and brain metastasis), which were used to create nomograms for predicting three-year and five-year OS and CSS. The nomograms had reasonable C-index values (OS: 0.687 [training] and 0.674 [validation], CSS: 0.712 [training] and 0.739 [validation]). The DCA curve revealed that the nomograms were better for predicting OS and CSS, relative to the Masaoka staging system. Conclusion: We developed nomograms using eight clinicopathological factors that predicted OS and CSS among TC patients. The nomograms performed better than the traditional Masaoka staging system and could identify high-risk patients. Based on the nomograms’ performance, we believe they will be useful prognostication tools for TC patients.

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Section: Discussionsupporting

confidence: 91%

Nomogram predicts the prognosis of patients with thymic carcinoma: A population-based study using SEER data

Huang

Liang

et al. 2022

Tumori

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“…Although supplying prognostic information, whether lymphadenectomy impacts on outcome remains less clear, with very little supporting evidence. A recent study showed better OS in patients undergoing intentional lymph node dissection for thymic tumours compared to those who did not (90 vs 50 months p ¼ 0.03) [71]. The levels suggested for clearance, include the N1 (low anterior cervical, perithymic, prevascular, para-aortic and supradiaphragmatic nodes) and N2 (deep intrathoracic including the lower jugular, supraclavicular, internal mammary, paratracheal, subaortic, subcarinal and hilar) nodes according to the ITMIG/IASLC lymph node map [59].…”

Section: Surgical Treatmentmentioning

confidence: 97%

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Lau

Cvasciuc

Simpson

et al. 2022

European Journal of Surgical Oncology

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“…Five studies [2,6,7,26,27] reported data on survival for both N0 and N+ patients with thymic cancers (Table 2). All these studies proved a significant difference when comparing the two groups of patients.…”

Section: Survival Rates According To the Ln Involvementmentioning

confidence: 99%

“…Almost no study reported data on survival stratified by histological type. Fifteen studies met the inclusion criteria and were included in this review [2][3][4][6][7][8][20][21][22][23][24][25][26][27][28]. Characteristics of the included studies are presented in Table 1.…”

Section: Survival Rates According To the Ln Involvementmentioning

confidence: 99%

“…A similar finding had been previously described by Weksler et al [6,7] who found that 84.6 and 80% of patients with thymic carcinoma and thymoma, respectively, were upstaged from lower stages because of node-positive status. A recent study by Song et al [26] collected data from the SEER database on a total of 362 patients with TC and NETTs to analyze clinicopathologic factors that impact on patients' prognosis, including intentional LND dissection. They found that the patients with positive regional lymph nodes had a shorter survival time than the negative ones (46 vs. 81 months; p = 0.004) and, interestingly, the patients who had undergone intentional LND had better OS than those who did not (90 vs. 50 months, p = 0.013).…”

Section: Lymph Node Dissection In Thymic Tumors: Is There a Role?mentioning

confidence: 99%

See 1 more Smart Citation

Lymph Nodes Involvement and Lymphadenectomy in Thymic Tumors: Tentative Answers for Unsolved Questions

Brascia

Palma

Schiavone

et al. 2021

Cancers

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Thymic tumors are the most common primary neoplasms of the anterior mediastinum, although, when compared with the entire thoracic malignancies, they are still rare. Few studies addressed the questions about lymph node involvement pattern in thymic neoplasms, about which subgroup of patients would be appropriate candidates for lymph node dissection or about the extent of lymphadenectomy or which lymph nodes should be harvested. The aim of this review is to collect evidence from the literature to help physicians in designing the best surgical procedure when dealing with thymic malignancies. A literature review was performed through PubMed and Scopus in May 2021 to identify any study published in the last 20 years evaluating the frequency and the extent of lymph node dissection for thymic tumors, its impact on prognosis and on postoperative management. Fifteen studies met the inclusion criteria and were included in this review, with a total of 9452 patients with thymic cancers; lymph node metastases were found in 976 (10.3%) patients in total. The current literature is heterogeneous in the classification and reporting of lymph node metastases in thymic carcinoma, and data are hardly comparable. Surgical treatment should be guided by the few literature-based pieces of evidence and by the experience of the physicians.

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Effect of clinicopathologic features on survival of patients with thymic carcinomas and thymic neuroendocrine tumors: A population-based analysis

Cited by 8 publications

References 16 publications

Nomogram predicts the prognosis of patients with thymic carcinoma: A population-based study using SEER data

Nomogram predicts the prognosis of patients with thymic carcinoma: A population-based study using SEER data

Continuing challenges of primary neuroendocrine tumours of the thymus: A concise review

Lymph Nodes Involvement and Lymphadenectomy in Thymic Tumors: Tentative Answers for Unsolved Questions

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