Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Aygün, Dursun; Akpınar, Çetin Kürşad; Yön, Serpil Kıroğlu; Onar, Musa

doi:10.5798/dicletip.338976

Cited by 3 publications

(5 citation statements)

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“…The available literature on the influence of autonomic dysfunction on cognitive function in Parkinson's disease is limited, and the findings are inconclusive. 8, 9 In one study, participants were evaluated for postprandial hypotension (PPH), heart rate responses during deep breathing (HR (DB)) and orthostatic hypotension (OH) in addition to the SCOPA-AUT scale. 8 The presence of orthostatic OH or PHP did not show a crucial association with cognition.…”

Section: Discussionmentioning

confidence: 99%

“…8 In a similar research performed in our country, no relationship was found between autonomic symptoms and cognitive tests. 9 In both studies, Mini-Mental State Exams (MMSE) were utilized for cognitive assessment. However, a comparative investigation suggests that the Montreal Cognitive Assessment Scale (MoCA) is a more effective tool than the MMSE within the PD population.…”

Section: Discussionmentioning

confidence: 99%

“…7 There is a limited body of literature evaluating the impact of autonomic dysfunction on cognition in PD, and the results are conflicting. 8,9 In this study, we aimed to evaluate the prevalence of autonomic symptoms, cognitive findings, and their correlation with disease parameters in early-stage PD patients following up by our movement disorders clinic.…”

Section: Introductionmentioning

confidence: 99%

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Autonomic symptoms in early-stage Parkinson’s patients and their relationship with cognition and disease parameters

KOBAK TUR,

GÖZKE

2023

Anatolian Current Medical Journal

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Aims: Autonomic dysfunction is a prevalent feature throughout various stages of the disease and can significantly exacerbate the overall impact of the condition. Moreover, it is linked to accelerated disease advances and diminished vitality rates in individuals with Parkinson’s disease (PD). The main goal of this study is to evaluate the prevalence of autonomic symptoms and cognitive findings and investigate their associations with disease-related factors in early-stage PD patients. Methods: A total of 49 individuals diagnosed with PD were enrolled in this study. Disease severity was assessed using the Unified Parkinson’s Disease Rating Scale (UPDRS), and the disease stage was determined through the modified Hoehn & Yahr Rating Scale (mHYRS). By the mH&Y scale, only individuals in the early stages (≤2.5) of the disease were included in this investigation. The evaluation of autonomic symptoms in PD was conducted using the Scales for Outcomes in Parkinson’s Disease for Autonomic Symptoms (SCOPA-AUT) scale. The cognitive functions of the patients were assessed utilizing the Turkish version of the Montreal Cognitive Assessment Scale (MOCA-TR). Results: The study included 44% (n=22) females and 56% (n=27) males as participants. The average age was 61.5±10.1 years. The mean SCOPA-AUT score was 18.9±9.36, with the most prevalent autonomic symptoms related to the gastrointestinal system. A positive correlation was shown with autonomic symptoms and disease stages (p=0.024, r=0.322). However, no significant relationship was found between autonomic symptoms, other disease parameters, and cognition. We observed a notable inverse correlation between the disease stage and cognitive status (p=0.003, r=-0.417). Conclusion: Our study concluded that autonomic dysfunctions manifest from the early stages of Parkinson’s disease and can intensify as the disease progresses. Identifying and addressing these dysfunctions at an early stage would play a pivotal role in lessening the overall impact of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Autonomic symptoms in early-stage Parkinson’s patients and their relationship with cognition and disease parameters

KOBAK TUR,

GÖZKE

2023

Anatolian Current Medical Journal

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“…Parkinson's disease (PD) is a neurodegenerative and progressive disease characterized clinically by bradykinesia, resting tremor, impaired postural reflexes, and rigidity (1). The essential criteria were determined by the Movement Disorders Association as bradykinesia with at least one of rigidity or resting tremor (2).…”

Section: Introductionmentioning

confidence: 99%

Parkinson Hastalığında Motor Semptomların Tiroid Hormon Seviyeleri ile İlişkisi

Ocak

Şahi̇n

Çam

2022

Düzce Tıp Fakültesi Dergisi

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Aim: This study aimed to investigate the relationship between thyroid hormone levels and the motor symptoms of Parkinson's patients. Material and Methods: Neurology clinic logs of the patients diagnosed with Parkinson's disease and whose thyroid function tests were measured between 01.01.2018 and 01.04.2021 were selected. Those with primary thyroid hormone disorder were excluded. Motor symptom stages were determined according to the modified Hoehn and Yahr scale (mHYS) by records. According to the thyroid function test results, whether there was a difference in motor symptoms, duration of the disease, and effects of the drugs were examined. Results: Of the 93 patients included in the study, 53 (57.0%) were male and 40 (43.0%) were female. The median age of the patients was 71 years. The motor symptoms of the patients were classified as stage 1 in 21 (22.6%), stage 1.5 in 18 (19.4%), stage 2 in 29 (31.2%), stage 2.5 in 13 (14.0%), stage 3 in 4 (4.3%), stage 4 in 6 (6.5%), and stage 5 in 2 (2.2%) patients. The median levels of TSH, fT3, and fT4 were 2.075 uIU/ml, 2.925 ng/dl, and 1.235 ng/dl, respectively. There was no significant correlation between the mHYS stages of the patients and TSH (r=-0.148, p=0.164), fT3 (r=-0.073, p=0.623), and fT4 levels (r=0.075, p=0.491). Conclusion: There was no relationship between the severity of motor symptoms and hormone levels in patients with normal thyroid functions. Thyroid dysfunction may mimic many motor findings, but they do not affect the severity of motor findings in Parkinson's patients.

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“…Parkinson's disease is a neurodegenerative disease caused mainly by the loss of dopaminergic cells in the substantia nigra (SN). 1 Parkinson disease (PD) has motor manifestations, namely resting tremor, rigidity, bradykinesia and postural instability. In addition, non-motor symptoms were also found, such as psychiatric symptoms such as depression, anxiety, hallucinations, psychosis, delusions and sleep disturbances which could be caused by anti-Parkinson medication itself or as part of the natural course of the disease.…”

Section: Introductionmentioning

confidence: 99%

Association Between Severity and Depression in Parkinson's Patients

2020

IJRSM

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Background: Parkinson disease (PD) has motor manifestations namely resting tremor, rigidity, bradykinesia and postural instability. In addition, non-motor symptoms such as psychiatric symptoms such as depression, anxiety, hallucinations, psychosis, delusions and sleep. Accompanying depression is the most common nonmotor symptom in Parkinson's. Depression in Parkinson's occurs in about 40% of patients and on average there is major depression and minor depression. Objective: To determine the relationship of severity with depression in Parkinson's patients. Method: This study used a cross sectional design. Sampling was conducted at H. Adam Malik General Hospital Medan and network hospital. The study sample was taken as many as 25 subjects consecutively, with primary data sources obtained from all patients who had been diagnosed with Parkinson's disease based on the UKPD Society Bank's Clinical Criteria for Probable Parkinson's Disease criteria. Data analysis using the Spearman correlation test. Results: The demographic characteristics of the study subjects were 19 (76%) men and 6 people (24%) women, with the oldest age being 77 years and the youngest 49 years, mean age was 61.52 ± 6.97 years. The majority of the patients are senior high school, self-employed, and the Batak ethnic group. There is a significant relationship between the MDS-UPDRS subscale and the level of depression in Parkinson's patients with a p value <0.05. Conclusion: There is a significant relationship between severity and depression in Parkinson's patients.

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Effect of clinical autonomic dysfunction on cognitive functions in Parkinson’s disease

Cited by 3 publications

References 25 publications

Autonomic symptoms in early-stage Parkinson’s patients and their relationship with cognition and disease parameters

Autonomic symptoms in early-stage Parkinson’s patients and their relationship with cognition and disease parameters

Parkinson Hastalığında Motor Semptomların Tiroid Hormon Seviyeleri ile İlişkisi

Association Between Severity and Depression in Parkinson's Patients

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