Effect of Clindamycin Therapy on Phagocytic and Oxidative Activity Profiles of Spleen Mononuclear Cells in Babesia rodhaini-infected Mice.

Abstract

ABSTRACT. Spleen weight, the number of spleen mononuclear cells, and their phagocytic activity in groups of Babesia rodhaini-infected mice treated with diminazene diaceturate and clindamycin increased significantly in the early stage of treatment, and then decreased in the final stage of treatment to approximately the pre-infection level. The number of F4/80-positive macrophages and their oxidative activity per mean whole-spleen weight also increased significantly during the course of treatment in comparison with the untreated group. The increases in the clindamycin-treated group were more prominent than those in the group treated with diminazene diaceturate, suggesting the effectiveness of clindamycin therapy for murine babesiosis. KEY WORDS: Babesia rodhaini infection, clindamycin, spleen macrophage function.

Combination Therapy with Clindamycin and Rifampicin for Hidradenitis Suppurativa: A Series of 116 Consecutive Patients

“…10 weeks for a disease which is not primarily infectious. Clindamycin and rifampicin have both antibacterial and anti-inflammatory effects [24,25,26,27,28]. Our data cannot elucidate the exact mechanism of the beneficial effect of clindamycin and rifampicin; nonetheless, we can hypothesize that their efficacy in HS, which is an inflammatory disease with bacterial superinfection, could be due to both antibacterial and anti-inflammatory properties.…”

A Possible Treatment Strategy and Clinical Factors to Estimate the Treatment Response in Bebesia gibsoni Infection

“…However, a recent report showed the possible induction of drug resistant mutants of B. gibsoni against this treatment protocol [14,16]. Another candidate for anti-babesia therapy, clindamycin has also been evaluated in the fields of medicine and veterinary medicine [6,[24][25][26][27]. Clindamycin is one of the lincomycin antibiotics which has been shown to be effective against human babesiosis [25][26][27].…”

“…Even though the combination therapy was terminated at 193 days PI, this dog never showed any signs of babesiosis by 662 days PI. To establish a new therapeutic strategy against B. gibsoni infection, we evaluated the effectiveness of a combination therapy with clindamycin, metronidazole and doxycycline, which were reported to be useful for canine, human and mouse babesioses [9,[23][24][25][26][27]. As shown in Fig.…”