Effect of cisplatin on the clinically relevant radiosensitivity of human cervical carcinoma cell lines

Britten, Richard A.; Evans, Andrew; Allalunis-Turner, M. J.; Pearcey, R.

doi:10.1016/0360-3016(95)02088-8

Cited by 60 publications

(37 citation statements)

References 28 publications

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“…Results from studies using exponentially growing cell cultures vary from a cisplatin-induced radiosensitisation (31)(32)(33)115), to a merely additive effect (29,31,(116)(117)(118). The effect of cisplatin treatment on radiosensitivity may depend on the cell type used.…”

Section: Discussionmentioning

confidence: 99%

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model

Franken

Oei

Kok

et al. 2013

International Journal of Oncology

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Abstract.The linear-quadratic model (LQ model) provides a biologically plausible and experimentally established method to quantitatively describe the dose-response to irradiation in terms of clonogenic survival. In the basic LQ formula, the clonogenic surviving fraction S d ̸S 0 following a radiation dose d (Gy) is described by an inverse exponential approximation:, wherein α and β are experimentally derived parameters for the linear and quadratic terms, respectively. Radiation is often combined with other agents to achieve radiosensitisation. In this study, we reviewed radiation enhancement ratios of hyperthermia (HT), halogenated pyrimidines (HPs), various cytostatic drugs and poly(ADP-ribose) polymerase-1 (PARP1) inhibitors expressed in the parameters α and β derived from cell survival curves of various mammalian cell cultures. A significant change in the α/β ratio is of direct clinical interest for the selection of optimal fractionation schedules in radiation oncology, influencing the dose per fraction, dose fractionation and dose rate in combined treatments. The α/β ratio may increase by a mutually independent increase of α or decrease of β. The results demonstrated that the different agents increased the values of both α and β. However, depending on culture conditions, both parameters can also be separately influenced. Moreover, it appeared that radiosensitisation was more effective in radioresistant cell lines than in radiosensitive cell lines. Furthermore, radiosensitisation is also dependent on the cell cycle stage, such as the plateau or exponentially growing phase, as well as on post-treatment plating conditions. The LQ model provides a useful tool in the quantification of the effects of radiosensitising agents. These insights will help optimize fractionation schedules in multimodality treatments.

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Section: Discussionmentioning

confidence: 99%

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model

Franken

Oei

Kok

et al. 2013

International Journal of Oncology

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“…Results from studies using exponentially growing cell cultures vary from a cisplatininduced radiosensitization (Loprevite et al, 2001;Begg et al 1986;Nakamoto et al 1996;Huang et al 2004) to only an additive effect (Gorodetsky et al, 1998;Loprevite et al, 2001;Britten et al, 1996;Monk et al, 2002). The effect of cisplatin treatment on radiosensitivity may depend on the cell type used.…”

Section: Wwwintechopencommentioning

confidence: 99%

“…Loprevite et al (2001) observed synergism in a squamous lung carcinoma cell line when exposed to cisplatin, whereas an adenocarcinoma of the lung was not sensitized by cisplatin. Even cell lines derived from a single biopsy can differ in the response to cisplatin and radiation combination therapy (Britten et al, 1996). Although dependence on cell cycle phase (Meyn et al, 1980;Krishnaswamy & Dewey, 1993), cisplatin incubation time and the sequence of treatment modalities have been implicated (Gorodetsky et al, 1998;Meyn et al, 1980;Krishnaswamy & Dewey, 1993), there is currently no consensus to account for the varying response of cells to cisplatin and radiation.…”

Section: Wwwintechopencommentioning

confidence: 99%

Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves

Franken¹,

Hovingh²,

Oei³

et al. 2012

Current Topics in Ionizing Radiation Research

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“…Indeed, clinical experience favors cisplatin as the drug of choice in various human tumors. However, some experimental data in vitro, especially on human cervix cancer cell lines, show that cisplatin leads to additive toxicity and not radiosensitization [4].…”

Section: Chemotherapymentioning

confidence: 99%

A survey on staging and treatment in uterine cervical carcinoma in the Radiotherapy Cooperative Group of the European Organization for Research and Treatment of Cancer

Coucke

Maingon

Ciernik

et al. 2000

Radiotherapy and Oncology

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Background: The treatment outcome of advanced stage uterine cervical carcinoma remains unsatisfactory. In order to elaborate a novel trial within The Radiotherapy Cooperative Group (RCG) of the European Organization for Research and Treatment of Cancer (EORTC), we conducted a survey in 1997±1998 to determine the variability of pre-treatment assessment and treatment options. The variability of choosing surgery, de®ned radiation therapy techniques and chemotherapy are investigated, as well as the center's choices of future treatment strategies.Methods: Fifty two of 81 RCG centers from the RCG have participated in the survey. As one would expect, there is a large variation in the techniques used for pretreatment evaluation and treatment options. There is no`standard' for reporting acute and late side effects. Chemotherapy is used neither systematically nor uniformly, and some centers continue to use neadjuvant chemotherapy modalities.Results: Furthermore, the survey reveals that there is a strong demand for the reduction of overall treatment-time, for clinical investigation of novel combined modality treatment strategies, especially chemo±radiation therapy, and also for the use of new radiation sensitizers.Conclusion: We conclude that a more homogeneous approach to the pretreatment evaluation as well as treatment techniques is required in order to allow adequate quality control in any future trial of the RCG in the EORTC. q

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Effect of cisplatin on the clinically relevant radiosensitivity of human cervical carcinoma cell lines

Cited by 60 publications

References 28 publications

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model

Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model

Radiosensitization with Hyperthermia and Chemotherapeutic Agents: Effects on Linear-Quadratic Parameters of Radiation Cell Survival Curves

A survey on staging and treatment in uterine cervical carcinoma in the Radiotherapy Cooperative Group of the European Organization for Research and Treatment of Cancer

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