Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4γ, HNF4α and IL6 in patients with ulcerative colitis

Bueno‐Hernández, Nallely; Sixtos-Alonso, M.S.; García, María del Pilar Milke; Yamamoto-Furusho, Jesús K.

doi:10.23736/s1121-421x.17.02367-4

Cited by 17 publications

(10 citation statements)

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“…PO blocks the inflammatory cascade triggered by endotoxins by downregulating the expression of Toll like receptor-4 (TLR-4) and nuclear factor-kappa B (NF-κB) and decreasing the production of pro-inflammatory cytokines in cultured primary macrophages 28 . PO treatment has been reported to be beneficial for patients with UC; however, there are no data on its use in patients with CD 29 . A previous study showed that the occurrence of SNPs near fatty acid desaturase 1 and glucokinase regulator was related to both increased serum PO levels and enhanced risk of CD in humans, thus indicating that high PO levels may be associated with an increased risk of CD.…”

Section: Discussionmentioning

confidence: 99%

Significance of serum palmitoleic acid levels in inflammatory bowel disease

Akazawa

Morisaki²,

Fukuda

et al. 2021

Sci Rep

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Inflammatory bowel diseases (IBDs), including ulcerative colitis (UC) and Crohn’s disease (CD), are chronic intestinal diseases of unknown etiology that present with variable disease extents and outcomes. The use of biomarkers for the diagnosis and management of IBDs is considered beneficial. Palmitoleic acid (PO) is an adipose tissue-derived mono-unsaturated free fatty acid that potentially serves as a lipokine in metabolic and inflammatory diseases. The aim of this study was to investigate the significance of PO levels in the serum of patients with UC and CD. The study included patients with UC (n = 22), patients with CD (n = 35), and controls (n = 22). The levels of serum PO were analyzed using gas chromatography. The association of serum PO levels with the clinical features and disease outcomes in IBD was examined. Serum PO levels were significantly higher in patients with CD than in controls, whereas no difference in these levels was observed between patients with UC and controls. Serum PO levels were significantly associated with the CD activity index. Additionally, high serum PO levels were associated with an increased risk of surgical intervention requirement during follow-up. In a pilot study with a few patients, high PO levels were observed in the mesenteric tissue in the active disease site of patients with CD (n = 7) compared with those with colon cancer (n = 6). Elevated serum PO levels might serve as a marker for local inflammation and prognosis in patients with CD.

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Section: Discussionmentioning

confidence: 99%

Significance of serum palmitoleic acid levels in inflammatory bowel disease

Akazawa

Morisaki²,

Fukuda

et al. 2021

Sci Rep

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“…Another study was carried out with 20 patients diagnosed with ulcerative colitis and indicated that supplementation with palmitoleic acid for 8 weeks was responsible for a significant reduction in interleukin-6 (a cytokine related to the inflammatory condition of the disease). In addition, some researchers have observed an increase in the gene expression of HNF4-γ (hepatocyte nuclear factor 4 gamma) and HNF-a (hepatocyte nuclear factor alpha), proteins that are also involved in the immune response to this condition (Bueno-Hernandez et al, 2017). In addition, group n-7 can be found in some oilseeds, such as macadamia and some tropical fish (Passos et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, group n-7 can be found in some oilseeds, such as macadamia and some tropical fish (Passos et al, 2016). In a balanced way, these fatty acids can be part of the diet, promoting their benefits to organic balance (Jankowska et al, 2010;Bueno-Hernandez et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Fatty acid profile, omegas, and lipid quality in commercial cuts of tambaqui (Colossoma macropomum Cuvier, 1818) cultivated in excavated tanks

et al. 2022

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This study aimed to determine the fatty acid profile, omegas, and lipid quality indices in commercial cuts of tambaqui (Colossoma macropomum). Samples were collected from two fish processing industries located in Rondônia state, Brazil. The experimental design was completely randomized, with processing performed in triplicate. Data were submitted for analysis of variance (ANOVA) to assess differences between commercial cuts. If ANOVA was statistically significant (α = 0.05), the averages were compared using Tukey's test. In the composition of fatty acids, there was a difference (p < 0.05) between commercial cuts. The commercial cuts with the highest percentages of saturated fatty acids (SFAs) steak at 47.050%, monounsaturated fatty acids (MUFAs) fillet at 45.120%, and polyunsaturated fatty acids (PUFAs) band at 19.050%. In addition, the band expresses the highest values of omegas 3, 6, 7, and n-9. The indices prescribed ∑PUFAs/∑SFAs, ∑PUFAs (n-6/∑n-3), atherogenicity index, thrombogenicity index, and ratio between hypocholesterolemic and hypercholesterolemic fatty acids, indicating that commercial cuts have lipid quality. Nutritional information is important for conservation and processing processes, the development of new products on the market, and guidance on the form of preparation, thus providing commercial security for different market niches.

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“…Endogenous palmitoleic acid can also be produced by adipocytes [ 4 ]. Palmitoleic acid has a positive preventive effect on diabetes, insulin resistance, inflammation, and metabolic syndrome [ 5 , 6 , 7 ]. Palmitoleic acid is considered to be a biologically active lipid that regulates the metabolic link between the liver and fat.…”

Section: Introductionmentioning

confidence: 99%

The Role of Palmitoleic Acid in Regulating Hepatic Gluconeogenesis through SIRT3 in Obese Mice

et al. 2022

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Hepatic gluconeogenesis is a crucial process to maintain glucose level during starvation. However, unabated glucose production in diabetic patients is a major contributor to hyperglycemia. Palmitoleic acid is a monounsaturated fatty acid (16:1n7) that is available from dietary sources. Palmitoleic acid exhibits health beneficial effects on diabetes, insulin resistance, inflammation, and metabolic syndrome. However, the mechanism by which palmitoleate reduces blood glucose is still unclear. SIRT3 is a key metabolism-regulating NAD+-dependent protein deacetylase. It is known that fasting elevates the expression of SIRT3 in the liver and it regulates many aspects of liver’s response to nutrient deprivation, such as fatty acid oxidation and ketone body formation. However, it is unknown whether SIRT3 also regulates gluconeogenesis. Our study revealed that palmitoleic acid reduced hepatic gluconeogenesis and the expression of SIRT3 under high-fat diet conditions. Overexpression of SIRT3 in the liver and hepatocytes enhanced gluconeogenesis. Further study revealed that SIRT3 played a role in enhancing the activities of gluconeogenic enzymes, such as PEPCK, PC, and MDH2. Therefore, our study indicated that under a high-fat diet, palmitoleic acid decreased gluconeogenesis by reducing enzymatic activities of PEPCK, PC, and MDH2 by down-regulating the expression of SIRT3.

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Effect of Cis-palmitoleic acid supplementation on inflammation and expression of HNF4γ, HNF4α and IL6 in patients with ulcerative colitis

Cited by 17 publications

References 0 publications

Significance of serum palmitoleic acid levels in inflammatory bowel disease

Significance of serum palmitoleic acid levels in inflammatory bowel disease

Fatty acid profile, omegas, and lipid quality in commercial cuts of tambaqui (Colossoma macropomum Cuvier, 1818) cultivated in excavated tanks

The Role of Palmitoleic Acid in Regulating Hepatic Gluconeogenesis through SIRT3 in Obese Mice

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