Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double‐blind placebo‐controlled trial

Zareie, Azadeh; Sahebkar, Amirhossein; Khorvash, Fariborz; Bagherniya, Mohammad; Hasanzadeh, Akbar; Askari, Gholamreza

doi:10.1002/ptr.6721

Cited by 24 publications

(14 citation statements)

References 43 publications

(56 reference statements)

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“…Conversely to these results, cinnamon supplementation did not significantly improve CRP in diabetic patients [31]. Cinnamon Ceylon (600 mg) for 60 days significantly reduced interleukin-6 and nitric oxide [32] in the intervention group compared to the control group. In T2DM patients, a randomized, double blind, and controlled trial showed that 3 g cinnamon extract supplementation for eight weeks did not significantly reduce NF-KB, IL-6, and IL-8 and TNF-alpha [33].…”

Section: Cinnamon Effects On Inflammatory and Oxidative Parameterscontrasting

confidence: 69%

Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review

et al. 2022

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The scientific evidence that cinnamon may exert beneficial effects on type 2 diabetes mellitus due to the biological activity of its bioactive compounds has been increasing in recent years. This review provides an overview of the effects of cinnamon on clinical parameters of diabetes and summarizes the molecular mechanisms of action of cinnamon on glucose and lipid metabolism. Search criteria include an electronic search using PubMed, Medline, and Cochrane Library databases. English literature references from 2000 up to 2022 were included. Following title and abstract review, full articles that met the inclusion criteria were included. The results from the available evidence revealed that cinnamon improved glycemic and lipidemic indicators. Clinical trials clarified that cinnamon also possesses an anti-inflammatory effect, which may act beneficially in diabetes. Based on in vitro and in vivo studies, cinnamon seems to elicit the regulation of glucose metabolism in tissues by insulin-mimetic effect and enzyme activity improvement. Furthermore, cinnamon seems to decrease cholesterol and fatty acid absorption in the gut. The current literature search showed a considerable number of studies on diabetic subjects. Some limitations in comparing published data should be highlighted, including variability in doses, extracts and species of cinnamon, administration forms, and antidiabetic therapy.

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Section: Cinnamon Effects On Inflammatory and Oxidative Parameterscontrasting

confidence: 69%

Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review

et al. 2022

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“…Zareie et al ( 167 ) assessed the effect of cinnamon on the inflammatory status and migraine attacks. They randomly divided fifty migraineurs into two groups; the experimental group received daily cinnamon powder, and the control group received a placebo for 2 months.…”

Section: Methodsmentioning

confidence: 99%

Immunologic aspects of migraine: A review of literature

et al. 2022

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Migraine headaches are highly prevalent, affecting 15% of the population. However, despite many studies to determine this disease's mechanism and efficient management, its pathophysiology has not been fully elucidated. There are suggested hypotheses about the possible mediating role of mast cells, immunoglobulin E, histamine, and cytokines in this disease. A higher incidence of this disease in allergic and asthma patients, reported by several studies, indicates the possible role of brain mast cells located around the brain vessels in this disease. The mast cells are more specifically within the dura and can affect the trigeminal nerve and cervical or sphenopalatine ganglion, triggering the secretion of substances that cause migraine. Neuropeptides such as calcitonin gene-related peptide (CGRP), neurokinin-A, neurotensin (NT), pituitary adenylate-cyclase-activating peptide (PACAP), and substance P (SP) trigger mast cells, and in response, they secrete pro-inflammatory and vasodilatory molecules such as interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) as a selective result of corticotropin-releasing hormone (CRH) secretion. This stress hormone contributes to migraine or intensifies it. Blocking these pathways using immunologic agents such as CGRP antibody, anti-CGRP receptor antibody, and interleukin-1 beta (IL-1β)/interleukin 1 receptor type 1 (IL-1R1) axis-related agents may be promising as potential prophylactic migraine treatments. This review is going to summarize the immunological aspects of migraine.

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“…Since almost no reports describing ethanolic CCE for human use have been published to date, future studies on COVID-19 patients should use the encapsulated powder. Typically, doses of encapsulated cinnamon vary between 500 mg and 3 g per day for adults (50)(51)(52)(53)(54). However, to the best of our knowledge, no study administering cinnamon alone or in combination with dexamethasone for COVID-19 has been published to date.…”

Section: Dosage Form and Dosagementioning

confidence: 99%

Ceylon cinnamon and its major compound Cinnamaldehyde can limit overshooting inflammatory signaling and angiogenesis in vitro: implications for COVID-19 treatment

Lucas

Ackermann

Leifke

et al. 2021

Preprint

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Overshooting immune reactions can occur during inflammatory responses that accompany severe infections, such as COVID-19. Cytokines, damage-associated molecular patterns (DAMPs), and reactive oxygen and nitrogen species can generate positive feedback loops of inflammation, leading to long-term complications such as vascular endothelialitis, thrombosis, endothelial dysfunction, neurological impairments, and chronic fatigue. Dexamethasone can limit inflammation by inhibiting the activation of pro-inflammatory transcription factors. High dose dexamethasone, however, has undesirable side effects. Here, we show that Ceylon cinnamon and its major compound cinnamaldehyde can mitigate inflammatory signaling in vitro. Cinnamaldehyde interferes with the dimerization of toll-like receptor 4 (TLR4), which can be activated by DAMPs like HSP60 and HMGB1. Our results suggest that supplementary treatment with Ceylon cinnamon may allow administration of lower doses of dexamethasone to avoid high dose steroid side effects. Moreover, preliminary results indicate that Ceylon cinnamon modulates angiogenesis, which is a reactive phenomenon in COVID-19.

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Effect of cinnamon on migraine attacks and inflammatory markers: A randomized double‐blind placebo‐controlled trial

Cited by 24 publications

References 43 publications

Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review

Cinnamon as a Complementary Therapeutic Approach for Dysglycemia and Dyslipidemia Control in Type 2 Diabetes Mellitus and Its Molecular Mechanism of Action: A Review

Immunologic aspects of migraine: A review of literature

Ceylon cinnamon and its major compound Cinnamaldehyde can limit overshooting inflammatory signaling and angiogenesis in vitro: implications for COVID-19 treatment

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