Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats

Muthenna, Puppala; Ganugula, Raghu; Kumar, P. Anil; Mullapudi, Surekha Venkata; Reddy, G. Bhanuprakash

doi:10.1016/j.cbi.2014.08.013

Cited by 44 publications

(20 citation statements)

References 40 publications

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“…Interestingly, eucalyptol diminished the AGE level in the circulation, while it prompted their urinary excretion. One similar study shows that cinnamon and its procyanidin‐B2 prevent the AGE mediated loss of expression of nephrin and podocin, leding to reduced urinary albumin and creatinine . Furthermore, RAGE activation increases reactive oxygen species production, which mediates hyperglycemia‐induced podocyte apoptosis by activation of the FOXO4 transcription factor .…”

Section: Discussionmentioning

confidence: 95%

Eucalyptol Inhibits Advanced Glycation End Products‐Induced Disruption of Podocyte Slit Junctions by Suppressing Rage‐Erk‐C‐Myc Signaling Pathway

Kim

Kang

Lee

et al. 2018

Molecular Nutrition Food Res

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Section: Discussionmentioning

confidence: 95%

Eucalyptol Inhibits Advanced Glycation End Products‐Induced Disruption of Podocyte Slit Junctions by Suppressing Rage‐Erk‐C‐Myc Signaling Pathway

Kim

Kang

Lee

et al. 2018

Molecular Nutrition Food Res

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“…Administration of AGEs into non-diabetic rats induced histological changes and albuminuria that were observed in DN [16,17]. On the other hand, preventing AGEs formation improved diabetic complications in animal models [18,19,[37][38][39]. These studies argue that AGEs are deleterious and are implicated in the etiology of DN.…”

Section: Discussionmentioning

confidence: 99%

“…The involvement of AGEs in the pathogenesis of renal damage has been supported by a study in non-diabetic rats wherein administration of AGEs induced proteinuria and histological changes that were observed in diabetic kidney disease [16,17]. On the other hand preventing AGEs formation attenuates diabetic complications [18,19]. In renal biopsies from patients with DN, AGE-accumulation is primarily found in GBM and its accumulation involves upregulation of receptor for AGE (RAGE) on podocytes [20].…”

Section: Introductionmentioning

confidence: 99%

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus

Kumar

Welsh

Ganugula

et al. 2016

Archives of Biochemistry and Biophysics

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Advanced glycation end-products (AGEs) are implicated in the pathogenesis of diabetic nephropathy (DN). N-carboxymethyl-lysine (CML) is one of the predominant AGEs that accumulate in all renal compartments of diabetic patients. Nevertheless, the direct effect of CML on podocyte biology has not been explored. In this study, we demonstrate the induction of the transcription factor Zeb2 in podocytes upon exposure to CML through activation of NF-kB signaling cascade. Zeb2 orchestrates epithelial-mesenchymal transformation (EMT), during which cell-cell and cell-extracellular matrix interactions are feeble and enable epithelial cells to become invasive. CML treatment induced both NF-kB and Zeb2 promoter activity and suppressed E-cadherin promoter activity. Inhibition of NF-kB activity prevented CML dependent induction of Zeb2 and loss of E-cadherin. While the exposure of podocytes to CML results in increased podocyte permeability, shRNA-mediated knockdown of Zeb2 expression abrogated CML-mediated podocyte permeability. Further, in vivo findings of elevated CML levels concurrent with increased expression of ZEB2 in glomeruli and proteinuria in diabetic rats confirm that CML-mediated manifestations in the kidney under chronic diabetes conditions. These in vitro and in vivo results envisage the novel axis of NFkB-ZEB2 in podocytes playing a significant role in eliciting EMT and pathogenesis of DN.

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“…The phenolic compounds detected in the extracts have already been reported as potent inhibitors of glycation. According to previous studies, resveratrol eliminates reactive oxygen species and captures MGO by conjugation reaction (Shen et al, ); procyanidin B2 prevents the accumulation of CML (AGE) in diabetic rat kidney (Muthenna, Raghu, Kumar, Surekha, & Reddy, ); catechin improves renal dysfunction in diabetic rats and inhibits pro‐inflammatory cytokines and AGEs formation (Zhu et al, ); quercetin reduces the levels of glycated hemoglobin and inhibits post‐Amadori glycation. (Alam et al, ), and caffeic acid significantly decreased AGEs levels (carboxymethyllysine and pentosidine) (Chao, Mong, Chan, & Yin, ).…”

Section: Resultsmentioning

confidence: 99%

Use of agro‐industrial residues as potent antioxidant, antiglycation agents, and α‐amylase and pancreatic lipase inhibitory activity

Fernandes

Martins

Moreira

et al. 2020

J Food Process Preserv

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Agro‐industrial residues are a potential source of bioactive compounds. This research is focused on the extraction of phenolic compounds from agro‐industrial residues produced in large scale in Brazil (peanut and grape marc), as well as to evaluate their antioxidant activity and ability to inhibit glycation reactions and digestive enzymes. As glycation is the main spontaneous cause of protein damage and is involved in the progression of diseases such as diabetes and obesity. The results showed that the major polyphenolics found in the residues were catechin and procyanidin B2. All extracts significantly inhibited the in vitro formation of advanced glycation end products and digestive enzymes (α‐amylase and lipase). This is the first study that compares the effects of peanut skin and grape pomace extracts against glycation. The results corroborate the understanding that using these phenolic extracts may have beneficial effects on preventing diseases related to glycation and suggest their use as a high value‐added agro‐industrial residue. Practical applications The glycation process causes oxidative stress, inflammatory responses in the human body, and is related to the progression of diabetes mellitus and obesity. This study showed that the selected industrial residues presented new results in their biological activities, mainly in relation to the high capacity to inhibit glycation and their high activity against alpha‐amylase and lipase enzymes. These residues can then be used for sustainable production of high added value products for both the food industry and the pharmaceutical industry.

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Effect of cinnamon and its procyanidin-B2 enriched fraction on diabetic nephropathy in rats

Cited by 44 publications

References 40 publications

Eucalyptol Inhibits Advanced Glycation End Products‐Induced Disruption of Podocyte Slit Junctions by Suppressing Rage‐Erk‐C‐Myc Signaling Pathway

Eucalyptol Inhibits Advanced Glycation End Products‐Induced Disruption of Podocyte Slit Junctions by Suppressing Rage‐Erk‐C‐Myc Signaling Pathway

Carboxymethyl lysine induces EMT in podocytes through transcription factor ZEB2: Implications for podocyte depletion and proteinuria in diabetes mellitus

Use of agro‐industrial residues as potent antioxidant, antiglycation agents, and α‐amylase and pancreatic lipase inhibitory activity

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