Effect of Cimetidine on the Gastric Bacterial Flora

Ruddell, W. S. J.; Axon, Anthony; Findlay, Jacqueline; Bartholomew, Barbara; Hill, M. J.

doi:10.1016/s0140-6736(80)92826-3

Cited by 134 publications

(22 citation statements)

References 16 publications

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“…Various synthetic antiulcer drugs are currently available, and some of these including RA, are representative histamine H 2 receptor antagonists specifically used to cure gastric ulcers. However, each of these drugs has simple‐to‐severe side effects (Miederer, 1986) including cardiac toxicity (Jakob et al., 2005), risk of pneumonia in hospitalized patients (Mallow et al., 2004), infectious diarrhea (Neal et al., 1994; Ruddell et al., 1980), the development of food allergies (Untersmayr et al., 2005), and thrombocytopenia (Bangia et al., 2011). …”

Section: Discussionmentioning

confidence: 99%

“…Although, it is likely to decrease mucosal perfusion in patients with acute renal or cardiac failure, and thereby increases the risk of death (Jakob, Parviainen, Ruokonen, Uusaro, & Takala, 2005). Infectious diarrhea (Neal, Briji, Slack, Hawkey, & Logan, 1994; Ruddell, Axon, Findlay, Bartholomew, & Hill, 1980), developing food allergies (Untersmayr et al., 2005), and thrombocytopenia (Bangia, Kamath, & Mohan, 2011) have also been reported as common side effects of histamine H 2 receptor antagonists (Yesilada & Gurbuz, 2003). In this experiment, RA 100 mg/kg was selected as a positive reference drug to compare the gastric mucosa protective effects based on the previous report (Grover et al., 2001).…”

Section: Introductionmentioning

confidence: 99%

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Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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This study was designed to observe the possible protective effects of a triple‐fermented barley (Hordeum vulgare L.) extract (FBe) obtained by saccharification and using Saccharomyces cerevisiae and Weissella cibaria in alleviating gastric damage induced by a hydrochloric acid (HCl) and ethanol (EtOH) mixture in mice. After oral administration of FBe (300, 200, and 100 mg/kg) followed by 1 hr before and after the single treatment of HCl/EtOH (H/E) mixture, the hemorrhagic lesion scores, histopathology of the stomach, gastric nitrate/nitrite content, lipid peroxidation, and antioxidant defense systems including catalase and superoxide dismutase activities were observed. Following a single oral treatment of H/E‐induced gastric damages as measured by hemorrhagic gross lesions and histopathological gastric, ulcerative lesions were significantly and dose‐dependently (p < 0.01 or p < 0.05) inhibited in mice, when all three different doses of FBe were administered as compared to those in H/E control mice. In particular, FBe also increased gastric nitrate/nitrite content and strengthened the antioxidant defense, with a decrease in the level of gastric lipid peroxidation, but increased the activities of CAT and SOD. Moreover, the effects of FBe are comparable to that of ranitidine, a reference drug. The obtained results suggest that this fermented barley extract prevented mice from H/E‐induced gastric mucosal damages through the suppression of inflammatory responses and oxidative stress‐responsive free radicals. Thus, FBe can be useful to treat patients suffering from gastric mucosal disorders as a potent food supplement, and thereby, it would increase the necessity of application in the food industry.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective effects of a triple‐fermented barley extract (FBe) against HCl/EtOH‐induced gastric mucosa damage in mice

Lim¹,

Song

Park

et al. 2018

Food Science & Nutrition

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“…Hypochlorhydria and achlorhydria (either secondary to gastric gland atrophy or drug-induced) are associated with an increased risk of enteric infections [83,84]. Early studies by Gray et al and Howden et al suggested that the degree of bacterial colonization is determined by the degree of reduction in gastric acid [85,86].…”

Section: Enteric Infectionsmentioning

confidence: 99%

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

2011

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Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency; hypomagnesemia; increased susceptibility to pneumonia, enteric infections, and fractures; hypergastrinemia and cancer; drug interactions; and birth defects. We explain the pathophysiological mechanisms that may underlie each of these relationships, review the existing evidence, and discuss implications for clinical management. The benefits of proton pump inhibitor use outweigh its risks in most patients. Elderly, malnourished, immune-compromised, chronically ill, and osteoporotic patients theoretically could be at increased risk from long-term therapy.

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“…Gastric microbial overgrowth is therefore a common nding in achlorhydric atrophic gastritis and pernicious anaemia (2,3), and during the use of gastric proton-pump inhibitors or H 2 -receptor antagonists (4)(5)(6)(7)(8).…”

mentioning

confidence: 99%