Effect of cilazapril therapy on glucose and lipid metabolism in patients with hypertension

Association of Angiotensin-Converting Enzyme Gene Polymorphism with Lipid Profiles in Children and Adolescents with Insulin-Dependent Diabetes mellitus

“…On the contrary, elaidic acid increases it [16]. Treatment with an ACE inhibitor can often improve lipid profiles, decreasing TC, low-density lipoprotein cholesterol, and TG, and increasing HDLC in patients with hypertension [17], although there has been no report regarding the effect of the ACE inhibitor on the Lp(a) level. Since the Lp(a) level correlated with the ratio of apo B/apo A-I and AI in this study, ACE inhibitors might, to a minor degree, improve lipid profiles through the renin-angiotensin system and/or kinin-kallikrein system in patients with the D allele of the ACE genotype, although the causal effect between Lp(a) and the ratio of apo B/apo A-I or AI requires further investigation.…”

Effects of ACE inhibition and AT1-receptor antagonism on endothelial function and insulin sensitivity in essential hypertensive patients

“…5 ACE-Is are known to improve insulin sensitivity. 8,13 Although the effects of ARBs on insulin sensitivity have been less extensively studied, conflicting results have been reported. 9,19 To our knowledge, this is the first study comparing the effects of an ACE-I and an ARB on endothelial function in relation to insulin sensitivity.…”

“…7 On the other hand, alpha-receptor antagonists, calcium channel blockers and angiotensin-converting enzyme (ACE) inhibitors have either neutral or favourable effects on glucose metabolism and insulin sensitivity. [7][8][9] Furthermore, in a study comparing different antihypertensive regimens, among ACE inhibitors (ACE-Is), calcium channel blocker, β-blockers and diuretics, ACE-Is were the only drugs which successfully increased post-ischaemic vasodilatation. 10 Angiotensin II (Ang II) receptor blockers (ARBs) are known to be as effective as ACE-Is in the treatment of hypertension, but their actions on glucose metabolism and endothelial function are controversial.…”

“…[3][4][5][6] Some antihypertensive drugs were demonstrated to modulate insulin resistance and endothelial function. [7][8][9] While commonly used drugs, such as thiazide diuretics and β-receptor antagonists are effective in the treatment of hypertension, they have been reported to impair insulin sensitivity. 7 On the other hand, alpha-receptor antagonists, calcium channel blockers and angiotensin-converting enzyme (ACE) inhibitors have either neutral or favourable effects on glucose metabolism and insulin sensitivity.…”