Effect of cigarette smoking on serum methylarginine and α-klotho levels

Onmaz, Mustafa; Demirbaş, Nur; Onmaz, Duygu Eryavuz; Kutlu, Ruhuşen; Ünlü, Ali

doi:10.1016/j.numecd.2022.12.020

Cited by 5 publications

(7 citation statements)

References 35 publications

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“…In the present study, serum α-klotho levels were found to be lower in current smokers than in nonsmokers. Mustafa et al found that serum α-klotho levels in healthy male smokers in Turkey were lower than those of nonsmokers, while Jennifer et al reported similar findings in preterm female smokers in the United States [ 17 , 18 ]. These findings are consistent with the results of the present study.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, finding factors affecting serum α-klotho levels is crucial in studying human anti-aging problem. Previous studies have shown that smoking and cessation affect serum α-klotho levels [16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

“…Japanese researchers found higher serum α-klotho levels in healthy male smokers compared with nonsmokers, while results in women were different and not statistically significant [ 16 ]. Turkish and American researchers observed lower serum klotho levels in smokers than nonsmokers in healthy men and preterm women, respectively [ 17 , 18 ]. Furthermore, researchers found that smokers had lower serum α-klotho levels after quitting smoking than when they were smoking [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Association between smoking, smoking cessation and serum α-klotho levels among American adults: National Health and Nutrition Examination Survey

Liu,

Song,

et al. 2024

PLoS ONE

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α-klotho is an anti-aging protein. The correlation between smoking, smoking cessation and serum α-klotho levels remains controversial. The aim of this study was to investigate the association between smoking, smoking cessation and serum α-klotho levels. This cross-sectional study finally included 4877 participants, aged 40–79 years, who participated in the National Health and Nutrition Examination Survey studies from 2013 to 2016. Of these, 2312 (47.4%) were men and 894 (18.3%) were current smokers, and the mean age of the participants was 57.8±10.7 years. Multivariate linear regression modeling was used to assess the association between smoking, smoking cessation and serum α-klotho levels. After adjustment for multiple confounders, this study observed that smoking was negatively associated with serum α-klotho levels (β: -58.3; 95% confidence interval CI: -82.0 to -34.6; p<0.001), whereas smoking cessation was positively associated with serum α-klotho levels (β: 52.3; 95% CI: 24.1 to 80.6; p<0.001). In subgroup and interaction analyses, p-value for the interaction between smoking and race on serum klotho levels was found to be less than 0.001. The correlation between smoking, smoking cessation and serum α-klotho levels remained stable after propensity score matching (β: -54.1; 95% CI: -81.5 to -26.7; p<0.001, β: 54.8; 95% CI: 24.2 to 85.4; p<0.001). In a large sample population, the present study found that smoking, smoking cessation and serum α-klotho levels were associated in opposite directions.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association between smoking, smoking cessation and serum α-klotho levels among American adults: National Health and Nutrition Examination Survey

Liu,

Song,

et al. 2024

PLoS ONE

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“…If klotho is a biomarker for healthspan potential, smoking would logically have a negative effect on its concentration in the blood. As a matter of fact, in a recent study, a decreased serum klotho level was measured in a group of smokers (n = 65) when compared to nonsmokers (n = 71) [98]. However, other studies have shown conflicting results.…”

Section: Tobaccomentioning

confidence: 97%

The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements

Paquette,

Rhéaume,

Cordeau

et al. 2023

Metabolites

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Aging is not a disease; it is a natural evolution of human physiology. Medical advances have extended our life expectancy, but chronic diseases and geriatric syndrome continue to affect the increasingly aging population. Yet modern medicine perpetuates an approach based on treatment rather than prevention and education. In order to help solve this ever-growing problem, a new discipline has emerged: lifestyle medicine. Nutrition, physical activity, stress management, restorative sleep, social connection, and avoidance of risky substances are the pillars on which lifestyle medicine is founded. The aim of this discipline is to increase healthspan and reduce the duration of morbidity by making changes to our lifestyle. In this review, we propose the use of klotho protein as a novel biomarker for lifestyle medicine in order to quantify and monitor the health status of individuals, as no integrative tool currently exists.

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“…Furthermore, systemic and local inflammation can decrease Klotho levels [ 28 ]. At the same time, dietary factors and lifestyle habits are highly associated with Klotho levels; for example, pro-inflammatory dietary patterns and smoking and alcohol consumption can lead to decreased Klotho levels [ 29 , 30 , 31 ]. High Mediterranean diet adherence favors elevated Klotho levels [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

Liu

Wang

et al. 2023

Nutrients

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Background: Klotho is an aging-related marker closely associated with a number of diseases. A growing body of evidence suggests that dietary factors and lifestyle habits can impact serum Klotho levels. The effect of dietary fiber, a key component of a healthy diet, on the body’s serum Klotho levels has not been fully elucidated. Objective: The aim of this study was to explore the relationship between dietary fiber intake and serum Klotho levels in people aged 40–79 years in the United States. Methods: A total of 11,282 participants were included in this study, all from the National Health and Nutrition Examination Survey from 2007 to 2016. Dietary fiber intake was assessed by uniformly trained interviewers using the 24 h dietary recall method. Serum Klotho was quantified using commercially available ELISA kits manufactured by IBL International, Japan. The relationship between dietary fiber intake and serum Klotho levels was analyzed using a multiple linear regression model. Subsequently, the non-linear dose–response relationship between the two was further explored using a restricted cubic spline (RCS) model. Results: After adjusting for potential confounders, serum Klotho levels increased by 1.9% (95% confidence interval [CI]: 0.8%, 3.0%) for each interquartile range increase in dietary fiber intake in all participants. Considering dietary fiber intake as a categorical variable, serum Klotho levels were found to be 4.7% higher in participants in the highest quartile of dietary fiber intake than in those in the lowest quartile (95% CI: 1.8%, 7.6%). RCS plots depicted a non-linear positive correlation between dietary fiber intake and serum Klotho levels. Subgroup analysis revealed that the relationship between dietary fiber intake and serum Klotho levels was more pronounced in older (percentage change: 7.0%; 95% CI: 2.5%, 11.7%) and overweight and obese participants (percentage change: 4.9%; 95% CI: 1.5%, 8.4%). Conclusions: The results of this study showed that dietary fiber intake was significantly associated with serum Klotho levels in participants. This finding is yet to be further confirmed by prospective studies.

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Effect of cigarette smoking on serum methylarginine and α-klotho levels

Cited by 5 publications

References 35 publications

Association between smoking, smoking cessation and serum α-klotho levels among American adults: National Health and Nutrition Examination Survey

Association between smoking, smoking cessation and serum α-klotho levels among American adults: National Health and Nutrition Examination Survey

The Longevity Protein Klotho: A Promising Tool to Monitor Lifestyle Improvements

The Association between Dietary Fiber Intake and Serum Klotho Levels in Americans: A Cross-Sectional Study from the National Health and Nutrition Examination Survey

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