Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study

Pasqualotto, Fábio Firmbach; Umezu, Fernanda M.; Salvador, Mirian; Borges, Edson; Sobreiro, Bernardo Passos; Pasqualotto, Eleonora Bedin

doi:10.1016/j.fertnstert.2008.02.123

Cited by 65 publications

(46 citation statements)

References 70 publications

(79 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Our data agree with those from other authors reporting a lower sperm quality in smoker patients (Kunzle et al, 2003;Pasqualotto et al, 2008). However, Ramlau-Hansen et al (2007a) demonstrated, in a large study of this field, an inverse dose-response relation between smoking and semen volume, total sperm count, and the percentage of motile sperm, concluding that current smoking in adult life moderately impairs semen quality.…”

Section: Discussionsupporting

confidence: 92%

“…On the other hand, other studies did not find any alterations in conventional semen parameters (Hoidas et al, 1985;Trummer et al, 2002;Sepaniak et al, 2006). In infertile smoking men, the antioxidant level, particularly the superoxide dismutase level, was recently found to be correlated with sperm concentration and negatively correlated with leukocytospermia (Pasqualotto et al, 2008).…”

mentioning

confidence: 93%

“…A consistent number of studies have claimed that cigarette smoking is correlated with alterations in sperm quality such as semen volume, sperm concentration, motility, and morphology (Vine et al, 1994;Zavos et al, 1998a,b;Ozgur et al, 2005;Guo et al, 2006;Pasqualotto et al, 2006Pasqualotto et al, , 2008Ramlau-Hansen, 2007a), concomitant with a reduced concentration mainly of citrate and also of fructose (Kunzle et al, 2003). On the other hand, other studies did not find any alterations in conventional semen parameters (Hoidas et al, 1985;Trummer et al, 2002;Sepaniak et al, 2006).…”

mentioning

confidence: 96%

See 2 more Smart Citations

Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Collodel

Capitani

Pammolli

et al. 2010

Journal of Andrology

View full text Add to dashboard Cite

This retrospective study was aimed at evaluating the effects of cigarette consumption on semen parameters in a group of men with idiopathic infertility. The semen quality of 2 groups of men with idiopathic infertility, smokers (n 5 118) and nonsmokers (n 5 153), were compared. Conventional semen analysis was performed and sperm morphology was assessed by transmission electron microscopy (TEM). TEM data were elaborated by means of a mathematical formula based on a Bayesian technique able to furnish a fertility index (FI), and the percentages of sperm apoptosis, necrosis, and immaturity. Values of normality recommended by World Health Organization guidelines were used as a control for conventional semen analysis, and values from sperm of 25 men of proven fertility were used for TEM indices. Infertile smoker and nonsmoker patients showed similar sperm parameters, although sperm motility and TEM analysis values in both groups were significantly impaired compared with controls. Smoker patients were then classified as mild ($1 and #10 cigarettes/d), moderate (.10 and ,20 cigarettes/day), or heavy smokers ($20 cigarettes/d). Sperm concentration and FI were significantly (P , .05) different among the 3 considered smoker classes. Comparing the pairs of smoker classes, sperm concentration and FI in heavy smokers were significantly lower (P , .05) than that observed in mild smoker and nonsmoker groups. Although semen quality in males with idiopathic infertility seems not to be dramatically affected by cigarette consumption, heavy smokers show significantly lower sperm concentration and FI: another strong reason to stop smoking.

show abstract

Section: Discussionsupporting

confidence: 92%

mentioning

confidence: 93%

mentioning

confidence: 96%

See 1 more Smart Citation

Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Collodel

Capitani

Pammolli

et al. 2010

Journal of Andrology

View full text Add to dashboard Cite

show abstract

“…An adverse effect of reactive oxygen species (ROS) on sperm quality is a possibility that could justify the observed sperm damage, since elevated levels of ROS have been found in infertile smoking men (28,40). Another causative factor would be the fact that seminal plasma in smokers contains lower levels of antioxidants than that of non smokers (28,41). Sperm nuclear chromatin abnormalities/ DNA damage could occur at the time of or result from DNA packing at spermatogenesis (42).…”

Section: Discussionmentioning

confidence: 99%

Apoptotic markers in semen of infertile men: association with cigarette smoking

El-Melegy

Ali

2011

Int. braz j urol.

View full text Add to dashboard Cite

Objectives: (i) To examine the role of apoptosis in the pathogenesis of DNA damage in semen from infertile men. (ii) To assess the effects of smoking on apoptotic markers and seminal parameters among infertile men. (iii) To assess the correlation of apoptosis with conventional semen parameters. Materials and Methods:The study was carried out on 70 men with idiopathic infertility, divided into two groups: thirty infertile non smokers and forty infertile smokers. In addition to 60 fertile men (30 non smokers and 30 smokers) as control group. Each subject provided semen for analysis of parameters, determination of % of DNA fragmentation, s-Fas, caspase-3 activity levels and cotinine levels. Results:The results revealed that infertile men, particularly smokers have significantly lower semen variables and significantly higher levels of apoptotic variables (% of DNA fragmentation, s-Fas and caspase-3 activity) in addition to cotinine. Conclusions:The present findings provide additional evidence supporting the importance of the evaluation of apoptotic markers to test male infertility particularly among smokers.

show abstract

“…Recent studies reported a significant decline in human semen quality or deterioration of spermatogenesis over the past decades (Fritsche et al, 1998;Alvarez and Moraes, 2006;Aydemir et al, 2007). Possible underlying reasons are yet unknown; however, xenobiotics have been suggested to exert adverse effects on the male reproductive system (Pasqualotto et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

Finotti

Silva²,

Bordin³

et al. 2009

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Male infertility is a heterogeneous disorder, with various genetic and environmental factors that contribute to the impairment of spermatogenesis. Genetic causes are responsible for 60% of cases of idiopathic infertility. Polymorphisms of genes that encode detoxifying enzymes of phase II drug metabolism can modify their expression or function, affecting the biotransformation of toxic compounds to which the male reproductive system is exposed. GSTM1 and GSTT1 encode enzymes that are essential in the process of detoxification of endogenous and exogenous xenobiotics, facilitating their excretion. We examined GSTM1 and GSTT1 polymorphism in 233 men with idiopathic infertility seen at the Human Reproduction Service of the Federal University of Goiás from [2004][2005][2006]. Genotype GSTM1/T1 (null) was found in 30/105 normal individuals and in 64/128 abnormal individuals, indicating a significant association with idiopathic male infertility. The sperm alteration associated with greater GSTM1/T1 (null) frequency was decreased sperm count (oligozoospermy), which was more frequent in patients with GSTM1 (78.9%) as well as in those who had GSTT1 (73.7%), although the difference was not significant. Individuals polymorphic for genes GSTM1 and GSTT1 are susceptible to reduction in sperm quality and infertility, possibly because oligozoo-

show abstract

Effect of cigarette smoking on antioxidant levels and presence of leukocytospermia in infertile men: a prospective study

Cited by 65 publications

References 70 publications

Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Semen Quality of Male Idiopathic Infertile Smokers and Nonsmokers: An Ultrastructural Study

Apoptotic markers in semen of infertile men: association with cigarette smoking

Glutathione S-transferase M1 and T1 polymorphism in men with idiopathic infertility

Contact Info

Product

Resources

About