Effect of ‘chronic’ versus ‘acute’ ketamine administration and its ‘withdrawal’ effect on behavioural alterations in mice: Implications for experimental psychosis

Chatterjee, Manavi; Ganguly, Shantanu; Srivastava, Mukesh; Palit, Gautam

doi:10.1016/j.bbr.2010.08.001

Cited by 102 publications

(89 citation statements)

References 38 publications

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“…Behavior assays were performed according to the method described previously (Chatterjee et al, 2011a), i.e., (a) hyperlocomotor activity (representing positive symptoms), (b) forced swim test (representing negative symptoms), and (c) passive avoidance test (representing cognitive symptoms). The experiments were carried out in two phases as follows.…”

Section: Behavioral and Biochemical Studiesmentioning

confidence: 99%

“…Gross open field activity (Chatterjee et al, 2011a) was studied using a Digiscan Infrared Photocell system (Omnitech Electronics, Columbus, OH) in 42 Â 42 Â 30 cm 3 plexiglass arena, fitted into infrared beam containing a metallic grid. The number of interruptions of the infrared beams along the spatial dimensions of the monitor by the animals was interpreted as horizontal activity and stereotypy counts.…”

Section: Locomotor Activitymentioning

confidence: 99%

“…The mice were subjected to a single trial passive avoidance test as described earlier (Chatterjee et al, 2011a). Briefly, each experimental mouse was placed in the lighted compartment of an automated shuttle box (Columbus Instruments, Columbus, OH) controlled by a software program PACS 30 (Opto 22, Temecula, CA).…”

Section: Passive Avoidance Testmentioning

confidence: 99%

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Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

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(2015) Antipsychotic activity of standardized Bacopa extract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems, Pharmaceutical Biology, 53:12, 1850-1860, DOI: 10.3109/13880209.2014 (40, 80, and 120 mg/kg, p.o.) were given to the mice 1 h prior to ketamine administration and tested for positive symptoms and cognitive deficits. A chronic ketamine treatment regimen was used to study the effect of BM on negative symptoms such as immobility enhancement. Each mouse was used once for the behavioral studies.Results: BM reduced ketamine-induced hyperactivity with an EC 50 value of 76.60 mg/kg. The 80 mg/kg dose was used for all other behavior analysis. Pretreatment with BM at 80 mg/kg showed two-fold increases in transfer latency time (TLT) in passive avoidance task. Chronic BM pretreatment (80 mg/kg p.o. daily Â 10 d) ameliorated the ketamine-induced enhanced immobility effect by 21% in the forced swim test. BM treatment reversed ketamine-induced increase in monoamine oxidase activity in both cortex and striatum and normalized the acetylcholinesterase activity and the glutamate levels in the hippocampus. Discussion and conclusion: Overall our findings suggest that BM possesses antipsychotic properties which might be due to its modulatory action on dopamine, serotonin, and glutamate neurotransmission.

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Section: Behavioral and Biochemical Studiesmentioning

confidence: 99%

Section: Locomotor Activitymentioning

confidence: 99%

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Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Chatterjee

Verma

Kumari

et al. 2015

Pharmaceutical Biology

Self Cite

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“…Using mice, other authors have demonstrated that repeated treatment with ketamine induces a persistent increase in the immobility time only when administered at a high (anesthetic) dose (100 mg/kg, i.p) (Chatterjee et al 2011, Hou et al 2013, Moghaddam et al 2014). However, there are studies conducted in rats that corroborate our findings.…”

Section: Discussionmentioning

confidence: 99%

“…Some authors characterized an increase in the immobility as a behavior related to apathy (Chatterjee et al 2011, Chindo et al 2012, Hou et al 2013, while others showed a decrease on this behavior (Akinfiresoye and Tizabi 2013, Garcia et al 2008b, Owolabi et al 2014, Parise et al 2013, Popik et al 2008, Tizabi et al 2012 probably related to the described rapid antidepressant effect of this drug (Rot et al 2010, Zarate et al 2006. In a recent review, Neill et al (2014) discuss this issue and highlight the necessity of more studies to achieve a better understanding of schizophrenia symptoms modeling by NMDAR antagonists using behavioral tasks associated to anhedonia and emotional blunting, especially in mice.…”

Section: Introductionmentioning

confidence: 99%

Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects

Neves

Borsoi

Antonio

et al. 2017

An. Acad. Bras. Ciênc.

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Immobility time in the forced swimming has been described as analogous to emotional blunting or apathy and has been used for characterizing schizophrenia animal models. Several clinical studies support the use of NMDA receptor antagonists to model schizophrenia in rodents. Some works describe the effects of ketamine on immobility behavior but there is variability in the experimental design used leading to controversial results. In this study, we evaluated the effects of repeated administration of ketamine subanesthetic doses in forced swimming, locomotion in response to novelty and novel object recognition, aiming a broader evaluation of the usefulness of this experimental approach for modeling schizophrenia in mice. Ketamine (30 mg/kg/day i.p. for 14 days) induced a not persistent decrease in immobility time, detected 24h but not 72h after treatment. This same administration protocol induced a deficit in novel object recognition. No change was observed in mice locomotion. Our results confirm that repeated administration of sub-anesthetic doses of ketamine is useful in modeling schizophrenia-related behavioral changes in mice. However, the immobility time during forced swimming does not seem to be a good endpoint to evaluate the modeling of negative symptoms in NMDAR antagonist animal models of schizophrenia.

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Withdrawal Assessment Following Subchronic Oral Ketamine Administration in Cynomolgus macaques

Walgren

Carfagna

Koger

et al. 2014

Drug Development Research

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Recently there is increased regulatory interest in the assessment of physical dependence and withdrawal as part of the safety assessment for novel therapeutic entities. Choosing appropriate and sensitive parameters to detect withdrawal syndromes, and relevant positive control comparator drugs that can be administered in the same manner as the test agent, are critical study design elements. Pilot studies to determine the effects of oral ketamine in cynomolgus monkeys during, and following cessation of treatment, were explored. Detailed behavioral observations (both remote and interactive), food consumption, and body weight and temperature, were assessed during the dose-ranging, repeat dose (5 or 14 days), and withdrawal phases (3 or 5 days). Doses explored during dose-ranging included 20, 40, 100, or 200 mg/kg ketamine; subsequent withdrawal assessments were conducted following repeat dosing of 150 mg/kg. In the 14-day dosing study, exposure to ketamine and norketamine was assessed following 8 days of dosing. Administration of 150 mg/kg ketamine produced decreased activity, loss of balance, ataxia, hunched posture, nystagmus, lateral recumbence, and changes in alertness levels during dosing phases. When ketamine was withdrawn, increased reactivity, increased activity, and stereotypic behaviors were demonstrated that were absent during baseline or the dosing phase of the studies.

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Effect of ‘chronic’ versus ‘acute’ ketamine administration and its ‘withdrawal’ effect on behavioural alterations in mice: Implications for experimental psychosis

Cited by 102 publications

References 38 publications

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Antipsychotic activity of standardizedBacopaextract against ketamine-induced experimental psychosis in mice: Evidence for the involvement of dopaminergic, serotonergic, and cholinergic systems

Is Forced Swimming Immobility a Good Endpoint for Modeling Negative Symptoms of Schizophrenia? - Study of Sub-Anesthetic Ketamine Repeated Administration Effects

Withdrawal Assessment Following Subchronic Oral Ketamine Administration in Cynomolgus macaques

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