Effect of chronic treatment with trandolapril or enalapril on brain ACE activity in spontaneously hypertensive rats

Jouquey, Simone; Mathieu, M.; Hamon, Gilles; Chevillard, Claude

doi:10.1016/0028-3908(95)00146-8

Cited by 30 publications

(18 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has not yet been definitively established that peripherally administered enalapril or losartan have central effects. Although some experiments demonstrate that these drugs act centrally when administered peripherally (Jouquey et al, 1995;Li et al, 1993;Rowland and Fregly, 1988;Song et al, 1991;Wong et al, 1991) other studies have suggested that higher doses than the one used in the current study are needed for central effects (Bui et al, 1992;Culman et al, 1999;Polidori et al, 1996;Rowland et al, 1996). Thus the current data cannot rule out a role for central Ang II in the regulation of core temperature and oxygen consumption in rats.…”

Section: Discussioncontrasting

confidence: 58%

Endogenous angiotensin II and the regulation of oxygen consumption and colonic temperature in rats

Barney

Greenheck

Nehs

et al. 2012

Journal of Thermal Biology

View full text Add to dashboard Cite

Section: Discussioncontrasting

confidence: 58%

Endogenous angiotensin II and the regulation of oxygen consumption and colonic temperature in rats

Barney

Greenheck

Nehs

et al. 2012

Journal of Thermal Biology

View full text Add to dashboard Cite

“…However, the cognitive outcomes were defined differently in the CHS (incident dementia, cognitive decline, or disability) (Sink et al 2009) and in the ILSA (incident MCI). Furthermore, conflicting evidence exists around the central action of lisinopril (Jackson et al 1987;Cushman et al 1989;Furberg and Pitt 2001) and ramipril (Furberg and Pitt 2001;Jouquey et al 1995). Clearly, the classification by either chemical structure or BBB penetrability has some limitations.…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

Solfrizzi

Scafato

Frisardi

et al. 2011

AGE

View full text Add to dashboard Cite

Midlife elevated blood pressure and hypertension contribute to the development of Alzheimer's disease (AD) and overall dementia. We sought to estimate whether angiotensin-converting enzyme AGE (2013) inhibitors (ACE-Is) reduced the risk of developing mild cognitive impairment (MCI) in cognitively normal individuals. In the Italian Longitudinal Study on Aging, we evaluated 1,445 cognitively normal individuals treated for hypertension but without congestive heart failure from a population-based sample from eight Italian municipalities with a 3.5-year follow-up. MCI was diagnosed with current clinical criteria. Dementia, AD, and vascular dementia were diagnosed based on DSM-IIIR criteria, NINCDS-ADRDA criteria, and ICD-10 codes. Among 873 hypertensiontreated cognitively normal subjects, there was no significant association between continuous exposure to all ACE-Is and risk of incident MCI compared with other antihypertensive drugs [hazard ratio (HR), 0.45, 95% confidence interval (CI), 0.16-1.28]. Captopril exposure alone did not significantly modify the risk of incident MCI (HR, 1.80, 95% CI,). However, the enalapril sub-group alone (HR, 0.17, 95% CI, 0.04 -0.84) or combined with the lisinopril sub-group (HR, 0.27, 95% CI, 0.08-0.96), another ACE-I structurally related to enalapril and with similar potency, were associated with a reduced risk of incident MCI. Study duration exposure to ACE-Is as a "class" was not associated with incident MCI in older hypertensive adults. However, within-class differences linked to different chemical structures and/or drug potencies may exist, with a possible effect of the enalapril and lisinopril sub-groups in reducing the risk of incident MCI.

show abstract

“…The latter is confirmed by the shift of the arterial baroreflex curve toward a higher pressure in the 9% offspring. As enalaprilat does not cross the blood-brain barrier (31), the effects observed after systemic administration of this ACE-I represent the role of peripherally derived AngII on cardiovascular function. Studies in mature animals have shown that circulating AngII alters baroreflex control of HR primarily by shifting the baroreflex curve to a higher blood pressure without modulating the gain (32,33).…”

Section: Table 2 Spectral Measurements Of Arterial Bpv In 9-to 12-wkmentioning

confidence: 99%

Role of Brain and Peripheral Angiotensin II in Hypertension and Altered Arterial Baroreflex Programmed during Fetal Life in Rat

et al. 2004

View full text Add to dashboard Cite

Intrauterine programming of hypertension is associated with evidence of increased renin-angiotensin system (RAS) activity. The current study was undertaken to investigate whether arterial baroreflex and blood pressure variability are altered in a model of in utero programming of hypertension secondary to isocaloric protein deprivation and whether activation of the RAS plays a role in this alteration. Pregnant Wistar rats were fed a normalprotein (18%) or low-protein (9%) diet during gestation, which had no effect on litter size, birth weight, or pup survival. Mean arterial blood pressure (MABP; 126 Ϯ 3 mm Hg 9% versus 108 Ϯ 4 mm Hg 18%; p Ͻ 0.05) and blood pressure variability were significantly greater in the adult offspring of the 9% protein-fed mothers. Arterial baroreflex control of heart rate, generated by graded i.v. infusion of phenylephrine and nitroprusside, was significantly shifted toward higher pressure; i.v. angiotensinconverting enzyme inhibitor normalized MABP and shifted the arterial baroreflex curve of the 9% offspring toward lower pressure without affecting the 18% offspring. For examining whether brain RAS is also involved in programming of hypertension, angiotensin-converting enzyme inhibitor and losartan (specific AT 1 receptor antagonist) were administered intracerebroventricularly; both significantly reduced MABP of the 9% but not the 18% offspring. Autoradiographic receptor binding studies demonstrated an increase in brain AT 1 expression in the subfornical organ and the vascular organ of the lamina terminalis in the 9% offspring. These data demonstrate a major tonic role of brain and peripheral RAS on hypertension associated with antenatal nutrient deprivation. Abbreviations ACE-I, angiotensin-converting enzyme inhibitor AngII, angiotensin II AP, area postrema BPV, blood pressure variability HR, heart rate ICV, intracerebroventricular MABP, mean arterial blood pressure MEPO, median preoptic nucleus NTS, nucleus of the solitary tract OVLT, vascular organ of the lamina terminalis PVH, paraventricular nucleus of the hypothalamus RAS, renin-angiotensin system SFO, subfornical organ Chronic cardiovascular diseases of adults can have their origins in fetal life. Epidemiologic studies reveal that hypertension, stroke, and coronary heart disease are inversely related to birth weight (1) and that this relationship is independent of genetic factors (2) and lifestyle (3). It has been suggested that a poor nutrient supply at a critical period of early development leads to permanent alterations in the programming of the developing cardiovascular structures or functions (4). This concept has been supported by animal studies demonstrating an association between nutritional deficit during fetal life and increased blood pressure in adulthood (5, 6).Experimental evidence suggests that activation of the reninangiotensin system (RAS) (7,8) is an important element of hypertension programmed during fetal life. Infants who are born with intrauterine growth restriction have increased plasma renin activity and r...

show abstract

Effect of chronic treatment with trandolapril or enalapril on brain ACE activity in spontaneously hypertensive rats

Cited by 30 publications

References 13 publications

Endogenous angiotensin II and the regulation of oxygen consumption and colonic temperature in rats

Endogenous angiotensin II and the regulation of oxygen consumption and colonic temperature in rats

Angiotensin-converting enzyme inhibitors and incidence of mild cognitive impairment. The Italian Longitudinal Study on Aging

Role of Brain and Peripheral Angiotensin II in Hypertension and Altered Arterial Baroreflex Programmed during Fetal Life in Rat

Contact Info

Product

Resources

About