Effect of chronic sublethal daily dosing of monocrotophos on some aspects of protein metabolism in rat brain

Swamy, K. Venkateswara; Ravikumar, R.; Mohan, P. Murali

doi:10.1007/bf00200786

Cited by 7 publications

(3 citation statements)

References 7 publications

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“…In the present study, the reason for decreased RNA levels in the liver of rats under the influence of abamectin treatment, might due to decreased mitotic index and disturbed cell division (Topaktas et al 1996) or caused by inhibitory action of pesticides on DNA and RNA synthesis (Walter et al 1980) or by cell death due to focal necrosis (Shivanandappa and Krishnakumari 1981). The decrease in total proteins and soluble proteins indicates their metabolic utilization (Swamy et al 1992). The increase in the activity of proteases was associated with the decrease of soluble and total protein.…”

Section: Discussionmentioning

confidence: 93%

Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

Abd-Elhady

Abouelghar

2013

Journal of Plant Protection Research

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Abamectin (Avermectin B1a), is a natural fermentation product derived from the soil bacterium Streptomyces avermitilis. Abamectin (Avermectin B1a) is widely used as an insecticide, acaricide, and anthelmintic. The present study assessed the effects of repeated subacute and subchronic exposure to the commercial formulation of abamectin (Vertemic, 1.8% EC) in albino male rats. The toxic effects of abamectin were studied. The various biochemical parameters and histopathological changes were noted. A stomach tube was used to orally administer sublethal doses of abamectin suspended in corn oil to the rats. The animals were divided into four groups. Rats of the group T1 were orally administered a sublethal dose of 30 mg/kg body weight (b.wt.) (1/10 LD50) three times a week for 30 days and the animals in group T2 were exposed to 10 mg/kg b.wt. (1/30 LD50) for 210 days, once a week. Two control groups (C1 and C2) were used in parallel studies, where animals were administered a corn oil vehicle. At the end of the study period, blood samples were collected from all groups to measure plasma alanine aminotransferase (ALT), aspartate aminotransferase (AST) activities, and the levels of creatinine and urea. Also, total protein and RNA contents were determined in the liver and kidney tissues. Changes in biochemical parameters were more intense in male rats from group T2 than those reported in group T1. The levels of ALT, AST, urea and creatinine were significantly elevated in rats from group T2 when compared to the control. In group T2, a significant decrease in the levels of total protein and RNA in both the liver and kidneys was observed. Fertility was also significantly reduced in male rats ingesting abamectin in group T2. The number of offspring was significantly reduced. Histopathological changes were more intense in male rats from group T2 than those from group T1. In conclusion, the results of this study demonstrate that subchronic oral administration of abamectin altered some biochemical parameters which correlated with histopathological changes

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Section: Discussionmentioning

confidence: 93%

Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

Abd-Elhady

Abouelghar

2013

Journal of Plant Protection Research

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“…The metabolic status of proteins indicates the physiological status of animal [55]. Also, the decrease in total proteins is due to their metabolic utilization [56]. In addition, in this study, it was observed that administration of vitamins C and/or E to rats exposed to gasoline vapors produced an appreciable improvement in the hepatotoxic effect associated with exposure.…”

Section: Discussionmentioning

confidence: 62%

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Sedky¹

2015

J. Sci. Res.

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The present work was designed to investigate the changes in some hematological, biochemical parameters and lipid profile as well as possible protective role of vitamins C and E against gasoline vapors induced toxicity in male rats. The present results showed that gasoline 80 vapors significantly decreased (p≤0.05) the concentration of total serum protein (TSP) and albumin concentrations and increased (p≤0.05) in serum activities of serum aminotransferases (ALT and AST) and alkaline phosphatase (ALP) compared to the control group. Also, exposure to gasoline 80 vapors induced significant decrease (p≤0.05) in hemoglobin concentration, red blood cell count (RBCs), packed cell volume (PCV) and high density lipoprotein cholesterol (HDL-C) compared to control group. On the other hand, exposure to gasoline 80 vapors resulted in significant increase (p≤0.05) in the levels of total cholesterol (TC), triglycerides (TGs), LDLcholesterol (LDL-C) and very low density lipoprotein cholesterol (VLDL-C) relative to untreated experimental animals. However, concomitant treatment with gasoline vapors and administration of vitamins C and E exhibited a protective role on the observed toxic effect of gasoline vapors in male rats. The results of the present study indicated that toxic effects of gasoline vapors could be reduced by dietary supplementation of vitamins C and E.

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“…Jan et al (2015) reported that even the protein structure is also greatly affected by the heavy metals as they displace the physiological metals bound to the protein ligands causing disruption in the cell physiology by changing their steric arrangements. Swamy, Ravikumar, and Murali Mohan (1992) suggested that the decrease in total proteins and soluble proteins indicates their metabolic utilization. They also associated the increase in proteases with decrease of soluble and total proteins.…”

Section: Discussionmentioning

confidence: 99%

Protective and therapeutic effects of garlic and tomato on cadmium-induced neuropathology in mice

Vijaya

Kaur

Garg³

et al. 2020

JoBAZ

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Background Heavy metals are natural components of the earth’s crust and are considered as constant environmental pollutants since they cannot be degraded or destroyed easily. Cadmium (Cd) is present primarily in the ores of zinc, copper, or lead; the extraction and processing of which releases large quantities of cadmium into the atmosphere, hydrosphere, and soil thereby contaminating the human environment. The present study aimed to investigate the possible protective and therapeutic effects of garlic and tomato extract on cadmium-induced AChE activity, biochemical parameters along with the pathological changes in the brain tissue of mice. Methods Male Swiss albino mice (n = 40) were divided into several experimental (protective and therapeutic) groups and were given single dose of cadmium (6 mg/kg bw) with supplementation of garlic (100 mg/kg bw) and tomato (50 mg/kg bw) extract for 15 and 30 days under protective and therapeutic study. Results Cadmium-treated mice showed a significant decline in AChE (p < 0.01) level and total proteins (p < 0.0001) but a nonsignificant decrease in glycogen, cholesterol in the brain tissue activity as compared to control group. The histological study also showed degeneration in the form of vacuolation, congestion, hyperemia, lymphocytic infiltration, and edema in the brain (cortex and hippocampus) of Cd-treated mice. But the antioxidant-treated groups showed significant increment in AChE level and other biochemical parameters in the protective study. But there were significant variations in the therapeutic study, and this was also confirmed by the histological analysis of the brain. Both tomato and garlic administration showed more attenuation in the brain AChE activity, and it may be due to the strong antioxidant potential of their constituents. Conclusion We can conclude that cadmium exposure should be avoided as it causes neuropathological effects. But in daily life, it may not be possible, so we should regularly intake natural antioxidants which may neutralize the effects of heavy metals to some extent.

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Effect of chronic sublethal daily dosing of monocrotophos on some aspects of protein metabolism in rat brain

Cited by 7 publications

References 7 publications

Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

Abamectin Induced Biochemical and Histopathological Changes in the Albino Rat, Rattus Norvegicus

Protective Effect of Vitamins C and E against Gasoline Vapors Induced Haematological and Biochemical Changes in Male Rats

Protective and therapeutic effects of garlic and tomato on cadmium-induced neuropathology in mice

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