Effect of Chronic Stress on The Testis of The Adult Male Albino Rat and The Role of Ginger

El-Naggar, Hadeer Abd El-Mohsen; El-Safty, Fatma El-Nabawia Abdel-Hady; El-Mehi, Abeer E.; Reafie, Ayman Abdallah

doi:10.21608/ejhm.2020.127968

Cited by 3 publications

(3 citation statements)

References 28 publications

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“…El-Naggar et al (2020) found that oral intake of ginger extract (400 mg/tablet) before exposure to chronic stress is more effective than after posttreatment. Pre-treatment with ginger improved the gonadosomatic index, testosterone level, and prevented testicular degeneration in male rats (El-Naggar et al, 2020).…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 98%

“…Another study by Kandeil et al (2019) showed that oral intake of water added ginger extract (100 mg/kg body weight) caused a significant increase in semen volume, and spermatozoa parameters (count, motility, viability), testicular size, production of testosterone, and body weight in V-line male rabbits (Kandeil et al, 2019). El-Naggar et al (2020) found that oral intake of ginger extract (400 mg/tablet) before exposure to chronic stress is more effective than after posttreatment. Pre-treatment with ginger improved the gonadosomatic index, testosterone level, and prevented testicular degeneration in male rats (El-Naggar et al, 2020).…”

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

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Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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Ginger (Zingiber officinale) is one of the most widely used natural products consumed as a spice and medicine for treating diabetes, flatulent intestinal colic, indigestion, infertility, inflammation, insomnia, a memory booster, nausea, rheumatism, stomach ache, and urinary tract infections. To date, over 400 bioactive components, such as diarylheptanoids, gingerol analogues, phenylalkanoids, sulfonates, monoterpenoid glycosides, steroids, and terpene compounds have been derived from ginger. Increasing evidence has revealed that ginger possesses a broad range of biological activities, especially protective effects against male infertility, nausea and vomiting, analgesic, anti-diabetic, anti-inflammatory, anti-obesity, and other effects. The pharmacological activities of ginger were mainly attributed to its active phytoconstituents such as 6-gingerol, gingerdiol, gingerol, gingerdione, paradols, shogaols, sesquiterpenes, zingerone, besides other phenolics and flavonoids. In recent years, in silico molecular docking studies revealed that gingerol (6-gingerol, 8-gingerol, and 10-gingerol) and Shogaol (6-shogaol, 8-shogaol, 10-shogaol) had the best binding affinities to the receptor protein in disease conditions such as diabetes, inflammation, obesity, and SARS-CoV-2. Furthermore, some clinical trials have indicated that ginger can be consumed for alleviation of nausea and vomiting induced by surgery, pain, diabetes, obesity, inflammation, male infertility. This review provides an updated understanding of the scientific evidence on the development of ginger and its active compounds as health beneficial agents in future clinical trials.

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Section: Protective Effects Against Male Infertilitymentioning

confidence: 98%

Section: Protective Effects Against Male Infertilitymentioning

confidence: 99%

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

et al. 2021

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“…It is straight forward to testicular physiology. This process depends on pituitary gonadotropins, follicle stimulant hormone (FSH) and luteinizing hormone (LH) as well as adequate testosterone hormone concentrations [10] . Evenly acute and chronic stress are effective to cause disturbance of male reproduction [11] .…”

Section: Introductionmentioning

confidence: 99%

Repeated restraint stress induced neurobehavioral and sexual hormone disorders in male rats

Matallah

Guezi

Bairi

2022

AIMSN

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<abstract> Several studies have demonstrated that depression include disruptions not only for mental human disorders but also their healthy living. Rodent-based behavioral tests and models are widely used to understand the mechanisms by which stress triggers anxiety-related behaviors. This present study examined the evidence of a chronic restraint stress (CRS) paradigm in male Wistar rats for the progressive nature of depression alongside with related changes in behavior and functions. The body weight was determined, and the behavior tests, including sucrose preference and the open field test were performed. Theses parameters confirme the presence of anxiety-like and depression-like behaviors beside that we will focus on the response of ACTH and testosterone concentrations in rats. The results obtained during the experiment show that CRS led to decrease the time spent in the field center, a decrease of total distance travelled, in the stressed group compared with the control group. A significant increased of ACTH levels and decreased in testosterone hormone levels in the CRS. According to these results the CRS rodent model has value to validating the development for depression. </abstract>

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Possible protective effects of vanillin against stress-induced seminiferous tubule injury via modulation of Nrf2 and ZO1

Abdel Hafez,

Saber,

Aziz

et al. 2024

Naunyn-Schmiedeberg's Arch Pharmacol

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Around 20% of the human population is distressed. Previous studies have looked into the relationship between restraint immobilization stress (IS) and sexual behavior in male rats. The current study aimed to provide a brief explanation of the mechanisms that generated testicular injury with chronic IS and an attempt to evaluate the mechanisms and effects of vanillin as a novel protective agent. Forty-eight adult male albino rats were divided into six groups: control, vanillin-treated, chronic 2-h IS, 2-h stressed-vanillin-treated, chronic 6-h IS, and 6-h stressed-vanillin treated. The rats were sacrificed, and blood samples were collected for biochemical study. The testes were processed for biochemical and histological study, as well as histological Johnsen score. The results showed that prolonged IS increased both corticosterone and TNF-α levels as well as decreased testosterone, luteinizing hormone, catalase, and Nrf2 levels. This effect was more pronounced after 6 h of IS compared to 2 h. It also induced various testicular injuries with weak ZO-1 and CD34 immunoreactions. On the contrary, vanillin improved all mentioned biochemical and histological alternations induced by stress. Additionally, computational molecular docking analyses were conducted on the compound vanillin within the active site of Zona Occludens-1 (PDB ID: 2JWE). The results demonstrated remarkable docking scores and binding affinity, corroborating its potential protective efficacy. It could be concluded that vanillin is a promising treatment alternative for protecting testicular tissue from the harmful effects of IS via its antioxidant and anti-inflammatory properties.

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Effect of Chronic Stress on The Testis of The Adult Male Albino Rat and The Role of Ginger

Cited by 3 publications

References 28 publications

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Ginger from Farmyard to Town: Nutritional and Pharmacological Applications

Repeated restraint stress induced neurobehavioral and sexual hormone disorders in male rats

Possible protective effects of vanillin against stress-induced seminiferous tubule injury via modulation of Nrf2 and ZO1

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