Effect of Chronic Regular Exercise on Serum Ischemia-Modified Albumin Levels and Oxidative Stress in Type 2 Diabetes Mellitus

Abstract

Objectives. Our aim was to determine the effect of chronic regular exercise on ischemia-modified albumin (IMA) levels and oxidative stress in type 2 diabetes mellitus (DM). Design and methods. Sixty patients with type 2 DM were randomly divided into two groups as exercise (17 M, 13 F) and non-exercise (12 M, 18 F) groups, each consisting of 30 patients. The exercise group underwent a 3-month aerobic regular exercise consisting of moderate-intensity power walking. The non-exercise subjects remained sedentary throughout the study period. Serum total antioxidant status (TAS), total oxidant status (TOS), and IMA levels of the groups were determined at baseline and 3 months later. Results. There was no significant change in TOS and IMA levels of exercise group but TAS levels were significantly increased (p < 0.05). Also, postexercise systolic (p < 0.001) and diastolic (p < 0.05) blood pressures of the exercise group were significantly lower than the baseline values. In addition, there was no significant change in TAS and TOS levels of the non-exercise group; however, IMA levels were significantly increased (p < 0.01). Conclusion. We have shown, for the first time, that exercise prevents increase in IMA levels in type 2 DM which might have resulted from increased levels of TAS and reduces the risk of ischemia in these patients. These findings show that chronic exercise is beneficial in the prevention of oxidative stress in patients with type 2 DM as documented by decreased IMA levels.

Volume of supervised exercise training impacts glycaemic control in patients with type 2 diabetes: a systematic review with meta-regression analysis

“…As shown in ESM Table 1, across 20 interventions of aerobic exercise training, [8,9,[22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38] the mean exercise frequency was three sessions per week, mean session duration was 48 min (not including warm-up and cool down), and mean exercise intensity was 74% of the HR max . In six trials (33%), exercise intensity was transformed from submaximal rates of V : O 2peak to the corresponding percentages of HR max .…”

Impact of Resistance Training on Quality of Life and Ischemia Modified Albumin Levels in Men with Cardiovascular Risk Factors

“…Most investigations involving IMA and physical activity have focused on the acute effects of exercise, [26][27][28][29] but only one study was found to investigate the chronic effects of exercise training (aerobic) in non-athletes 30 and no studies were found regarding RT and IMA levels. In this matter, three months of moderate-intensity walking unchanged IMA levels in type 2 diabetes mellitus patients, while its levels increased in the sedentary group.…”

Association of ischemia-modified albumin with oxidative stress status and insulin resistance in obese patients

“…Our study group consisted of outpatient individuals who attended regular check-ups. Reducing oxidative stress may be possible by various lifestyle modifications, such as changes in dietary intake (2), lowering insulin resistance and lipids via nutritional modifications (16), weight loss (14,16,26) and chronic exercise (27). However, the general consensus is that obesity is a cause of increased oxidative stress (14-17).…”