Effect of Chronic Poisoning by Emetine on Oxidative Process in Rat Heart II

Appelt, Glenn D.; Heim, Harold C.

doi:10.1002/jps.2600541113

Cited by 16 publications

(1 citation statement)

References 9 publications

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“…Another possibility arose from a consideration of the work of Appelt & Heim (1965), who had shown that emetine inhibited the NADW-dependent oxidation of substrates by rat heart homogenates without marked interference in the rate of NAD+ synthesis. Similarly, Watkins & Guess (1968) had suggested that emetine inhibited NADH formation, thus uncoupling oxidative phosphorylation and decreasing ATP production in embryonic chick heart.…”

Section: Discussionmentioning

confidence: 99%

Hepatic drug-metabolizing enzyme activity in rats pretreated with (−)-emetine or (±)-2,3-dehydroemetine

Miller

Johnson

Donahue

et al. 1970

Biochemical Journal

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1. Pretreatment of female rats with (-)-emetine or (+/-)-2,3-dehydroemetine (at 18mumol/kg body wt. for 24h) prolongs the hexobarbital-induced sleeping-time of the treated animals. 2. This effect is not observed on pretreating animals with other compounds closely related to (-)-emetine, such as (-)-isoemetine or (+)-O-methylpsychotrine. 3. Liver microsomal drug-metabolizing enzyme activity in vitro as measured by N-demethylation of aminopyrine and azo-reduction of Neoprontosil is inhibited in rats pretreated with (-)-emetine or with (+/-)-2,3-dehydroemetine. 4. These inhibitory effects on drug metabolism in vitro are not observed in corresponding experiments involving pretreatment of rats with (-)-isoemetine or (+)-O-methylpsychotrine. 5. Co-administration of emetine or 2,3-dehydroemetine and sodium phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane to rats abolishes or greatly diminishes the stimulation of drug-metabolizing enzyme activity in vitro usually obtained by the administration of phenobarbital or 1,1-dichloro-2-o-chlorophenyl-2-p-chlorophenylethane alone. 6. Further, in rats pretreated with sodium phenobarbital and subsequently injected with emetine or 2,3-dehydroemetine the pre-stimulated drug-metabolizing enzyme activity in vitro is diminished. 7. The inhibitory effects on drug-metabolizing enzyme activity after pretreatment with (-)-emetine or (+/-)-2,3-dehydroemetine do not appear to be related to NADPH generation.

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Section: Discussionmentioning

confidence: 99%