Effect of chronic oral administration of the CCK receptor antagonist loxiglumide on exocrine and endocrine pancreas in normal rats

Imoto, Issei; Yamamoto, Masahiro; Jia, Dong; Ōtsuki, Makoto

doi:10.1007/bf02788382

Cited by 5 publications

References 42 publications

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Immunoelectron Study of Pancreatic Carcinomas Using Antibodies to Gastrointestinal Hormones

Seretis

Gavriil

Golematis

et al. 2007

Ultrastructural Pathology

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The aim of this study was to investigate the ultrastructural appearance of pancreatic adenocarcinoma combined with glucagon and gastrin/cholecystokinin (CCK) expression. The authors investigated the ultrastructure and the immunocytochemistry of 12 human pancreatic cancer specimens and used 3 chronic pancreatitis samples and 6 adjacent histological normal pancreatic tissues (away from the tumor) as controls. The ultrastructural study revealed that chronic pancreatitis tissues were characterized by alterations of the secretory cells. The enzymic and secretory changes were confirmed by electron immunogold results. Glucagon appeared to be located not only in islet alpha cells but also in intermediate alpha acinar cells. The changes were more significant in adenocarcinoma cases. Abnormality in the immunoreaction of the peptides was indicated not only in the tumor area but also in the islets near the cancer. Cells immunoreactive with antibodies were found in all 12 adenocarcinoma cases. Abnormal co-location of both hormones in the same type of endocrine cell was also found. Moderately to poorly differentiated adenocarcinomas were poorly granulated compared with differentiated tumors. Increased and ectopic gastrin/CCK expression was correlated with pancreatic adenocarcinomas exhibiting poor histological grade and neoplastic endocrine cells, providing a potential marker for pancreatic adenocarcinomas with aggressive behavior.

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Immunoelectron Study of Pancreatic Carcinomas Using Antibodies to Gastrointestinal Hormones

Seretis

Gavriil

Golematis

et al. 2007

Ultrastructural Pathology

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Effect of Cholecystokinin-A Receptor Antagonist on Rat Pancreas after Partial Pancreatectomy

Handa

Suzuki

Hayashi

et al. 2004

Acta Histochem. Cytochem

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Cholecystokinin expression in the developing and regenerating pancreas and intestine

Liu

Pakala

et al. 2001

Journal of Endocrinology

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In developmental terms, the endocrine system of neither the gut nor the pancreatic islets has been characterized fully. Little is known about the involvement of cholecystokinin (CCK), a gut hormone, involved in regulating the secretion of pancreatic hormones, and pancreatic growth. Here, we tracked CCK-expressing cells in the intestines and pancreata of normal mice (BALB/c), Non Obese Diabetic (NOD) mice and interferon (IFN)-transgenic mice, which exhibit pancreatic regeneration, during embryonic development, the postnatal period and adulthood. We also questioned whether IFN-influences the expression of CCK. The results from embryonic day 16 showed that all three strains had CCK in the acinar region of pancreata, and specifically in cells that also expressed glucagon. However, in adulthood only BALB/c and NOD mice continued this pattern. By contrast, in IFNtransgenic mice, CCK expression was suppressed from birth to 3 months of age in the pancreata but not intestines. However, by 5 months of age, CCK expression appeared in the regenerating pancreatic ductal region of IFNtransgenic mice. In the intestine, CCK expression persisted from fetus to adulthood and was not influenced by IFN-. Intestinal cells expressing CCK did not co-express glucagon, suggesting that these cells are phenotypically distinct from CCK-expressing cells in the pancreatic islets, and the effect of IFN-on CCK varies depending upon the cytokine's specific microenvironment.

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Effect of chronic oral administration of the CCK receptor antagonist loxiglumide on exocrine and endocrine pancreas in normal rats

Cited by 5 publications

References 42 publications

Immunoelectron Study of Pancreatic Carcinomas Using Antibodies to Gastrointestinal Hormones

Immunoelectron Study of Pancreatic Carcinomas Using Antibodies to Gastrointestinal Hormones

Effect of Cholecystokinin-A Receptor Antagonist on Rat Pancreas after Partial Pancreatectomy

Cholecystokinin expression in the developing and regenerating pancreas and intestine

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