Effect of Chronic Iron Deficiency on Neuropsychological Domains in Infants

Beltrán-Navarro, Beatriz; Matute, Esmeralda; Vásquez‐Garibay, Edgar M.; Zarabozo, Daniel

doi:10.1177/0883073811416867

Cited by 27 publications

(34 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a recent study,37 a chronic ID group showed significantly lower scores on language, environmental sound perception, and motor measures when compared with infants with normal nutritional iron status at 6 months and 14–18 months. The conclusion was that the development of language and motor skills and environmental sound perception appeared to be sensitive to the effects of chronic ID in infants.…”

Section: Resultsmentioning

confidence: 90%

Iron deficiency and cognitive functions

Jáuregui‐Lobera¹

2014

NDT

223

160

View full text Add to dashboard Cite

Micronutrient deficiencies, especially those related to iodine and iron, are linked to different cognitive impairments, as well as to potential long-term behavioral changes. Among the cognitive impairments caused by iron deficiency, those referring to attention span, intelligence, and sensory perception functions are mainly cited, as well as those associated with emotions and behavior, often directly related to the presence of iron deficiency anemia. In addition, iron deficiency without anemia may cause cognitive disturbances. At present, the prevalence of iron deficiency and iron deficiency anemia is 2%–6% among European children. Given the importance of iron deficiency relative to proper cognitive development and the alterations that can persist through adulthood as a result of this deficiency, the objective of this study was to review the current state of knowledge about this health problem. The relevance of iron deficiency and iron deficiency anemia, the distinction between the cognitive consequences of iron deficiency and those affecting specifically cognitive development, and the debate about the utility of iron supplements are the most relevant and controversial topics. Despite there being methodological differences among studies, there is some evidence that iron supplementation improves cognitive functions. Nevertheless, this must be confirmed by means of adequate follow-up studies among different groups.

show abstract

Section: Resultsmentioning

confidence: 90%

Iron deficiency and cognitive functions

Jáuregui‐Lobera¹

2014

NDT

223

160

View full text Add to dashboard Cite

show abstract

“…Beltrán-Navarro et al used the Bayley Scales of Infant Development, preschool language scales and an environmental sound perception task to assess the effect of IDA on multifaceted development in infancy (at 6 and 14 to 18 months) and showed that infants with chronic IDA did show significantly lower scores on language, environmental sound perception, and motor measures, when compared with infants with a normal iron nutritional status [42]. Studying the long-term developmental outcome of infants with IDA, Lozoff et al found lower scores on tests of mental (i.e., intelligence) and motor functioning at age of 5 and 12 among those with IDA in infancy [31,40].…”

Section: Discussionmentioning

confidence: 99%

Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study

et al. 2013

View full text Add to dashboard Cite

BackgroundA great deal of evidence has shown that iron is an important component in cognitive, sensorimotor, and social-emotional development and functioning, because the development of central nervous system processes is highly dependent on iron-containing enzymes and proteins. Deficiency of iron in early life may increase the risk of psychiatric morbidity.MethodsUtilizing the National Health Insurance Database from 1996 to 2008, children and adolescents with a diagnosis of IDA were identified and compared with age and gender-matched controls (1:4) in an investigation of the increased risk of psychiatric disorders.ResultsA total of 2957 patients with IDA, with an increased risk of unipolar depressive disorder (OR = 2.34, 95% CI = 1.58 ~ 3.46), bipolar disorder (OR = 5.78, 95% CI = 2.23 ~ 15.05), anxiety disorder (OR = 2.17, 95% CI = 1.49 ~ 3.16), autism spectrum disorder (OR = 3.08, 95% CI = 1.79 ~ 5.28), attention deficit hyperactivity disorder (OR = 1.67, 95% CI = 1.29 ~ 2.17), tic disorder (OR = 1.70, 95% CI = 1.03 ~ 2.78), developmental delay (OR = 2.45, 95% CI = 2.00 ~ 3.00), and mental retardation (OR = 2.70, 95% CI = 2.00 ~ 3.65), were identified. A gender effect was noted, in that only female patients with IDA had an increased OR of bipolar disorder (OR = 5.56, 95% CI = 1.98 ~ 15.70) and tic disorder (OR = 2.95, 95% CI = 1.27 ~ 6.86).ConclusionIron deficiency increased the risk of psychiatric disorders, including mood disorders, autism spectrum disorder, attention deficit hyperactivity disorder, and developmental disorders. Further study is required to clarify the mechanism in the association between IDA and psychiatric disorder.

show abstract

“…Blood iron availability is reduced by inflammation, and its prenatal deficiency is associated with myelin reductions in animal models [34,62] , behavioural deficits in infants [63] and also schizophrenia [64,65] . We found ferritin heavy chain, which is expressed abundantly in oligodendrocytes [66] , to be downregulated following poly(I:C).…”

Section: Discussionmentioning

confidence: 99%

Maternal Immune Activation Induces Changes in Myelin and Metabolic Proteins, Some of Which Can Be Prevented with Risperidone in Adolescence

Farrelly

Föcking²,

Piontkewitz³

et al. 2015

Dev Neurosci

View full text Add to dashboard Cite

Background: Maternal infection is a risk factor for schizophrenia but the molecular and cellular mechanisms are not fully known. Myelin abnormalities are amongst the most robust neuropathological changes observed in schizophrenia, and preliminary evidence suggests that prenatal inflammation may play a role. Methods: Label-free liquid chromatography-mass spectrometry was performed on the prefrontal cortex (PFC) of adult rat offspring born to dams that were exposed on gestational day 15 to the viral mimic polyinosinic:polycytidylic acid [poly(I:C), 4 mg/kg] or saline and treated with the atypical antipsychotic drug risperidone (0.045 mg/kg) or saline in adolescence. Western blotting was employed to validate protein changes. Results: Over 1,000 proteins were quantified in the PFC with pathway analyses implicating changes in core metabolic pathways, following prenatal poly(I:C) exposure. Some of these protein changes were absent in the PFC of poly(I:C)-treated offspring that subsequently received risperidone treatment in adolescence. Particularly interesting reductions in the expression of the myelin-related proteins myelin basic protein isoform 3 (MBP1) and rhombex 29 were observed, which were reversed by risperidone treatment. Validation by Western blotting confirmed changes in MBP1 and mitogen-activated kinase 1 (MAPK1). Western blotting was extended to assess the MAPK signalling proteins due to their roles in inflammation, namely phosphorylated MAPK1 and phosphorylated MAPK-activated protein kinase 2. Both were upregulated by poly(I:C) treatment and reversed by risperidone treatment. Conclusions: Overall, our data suggest that maternal inflammation may contribute to an increased risk for schizophrenia through mechanisms involving metabolic function and myelin formation and that risperidone in adolescence may prevent or reverse such changes.

show abstract

Effect of Chronic Iron Deficiency on Neuropsychological Domains in Infants

Cited by 27 publications

References 27 publications

Iron deficiency and cognitive functions

Iron deficiency and cognitive functions

Association between psychiatric disorders and iron deficiency anemia among children and adolescents: a nationwide population-based study

Maternal Immune Activation Induces Changes in Myelin and Metabolic Proteins, Some of Which Can Be Prevented with Risperidone in Adolescence

Contact Info

Product

Resources

About