Effect of chronic intramuscular administration of low molecular weight heparin-collagen complex on hemostatic indices and development of alloxan-induced diabetes

Lyapina, L. A.; Ul’yanov, A. M.; Pastorova, V. E.; Оберган, Т.Ю.

doi:10.1134/s1062359006030150

Cited by 1 publication

(1 citation statement)

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“…Moreover, collagen can promote granulation tissue formation, accelerate wound healing, activate macrophage phagocytosis, increase the body's immune activity, and reduce the probability of wound infection. [17][18][19][20][21] Although collagen offers many advantages as a frequently used hemostatic material, it tends to degrade easily. In general, a single-component material is often insufficient to provide good biodegradability or hemostatic properties.…”

Section: Introductionmentioning

confidence: 99%

Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study

Ding

et al. 2015

J Biomater Appl

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To develop biocompatible composite microspheres for novel hemostatic use, we designed and prepared a novel biomaterial, composite microspheres consisting of carboxymethyl chitosan, sodium alginate, and collagen (CSCM). The ultra-structure of CSCM was investigated by scanning electron microscopy assay. In hemostatic function experiment, it was found that CSCM could facilitate platelet adherence, platelet aggregation, and platelet activation in vitro. Besides, the maximum swelling of CSCM submerged in PBS for 50 min was over 300% of that exhibited by commercial hemostatic compound microporous polysaccharide haemostatic powder (CMPHP). In addition, CSCM exhibited good biodegradability and non-cytotoxicity. These results demonstrated that CSCM may be useful in platelet plug formation, and this study would provide important information for further research on hemostasis experiment in vivo.

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Section: Introductionmentioning

confidence: 99%

Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study

Ding

et al. 2015

J Biomater Appl

View full text Add to dashboard Cite

show abstract

Effect of chronic intramuscular administration of low molecular weight heparin-collagen complex on hemostatic indices and development of alloxan-induced diabetes

Cited by 1 publication

References 8 publications

Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study

Microspheres of carboxymethyl chitosan, sodium alginate and collagen for a novel hemostatic in vitro study

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