Effect of chronic hypoxia on glutathione status and membrane integrity in the pancreas

Ip, Siu‐Po; Chan, Yiu-Pong; Che, Chun‐Tao; Leung, Po Sing

doi:10.1159/000049446

Cited by 13 publications

(4 citation statements)

References 38 publications

(36 reference statements)

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“…A possible mechanism is that the activity of angiotensin II is increased in the circulatory system of patient with hypertension. Angiotensin II activates renin-angiotensin-aldosterone system (RAAS) and affects the function of the pancreatic islets, resulting in islet fibrosis and reduced synthesis of insulin, and ultimately leading to insulin resistance [34,35]. Insulin resistance can also aggravate the condition of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China

Zhao

Lin

Yuan

et al. 2016

IJERPH

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Objective: The aims of the study were to investigate the prevalence of pre-diabetes and explore its associated risk factors in rural areas of Ningbo, China. Methods: A cross-sectional survey was conducted with 4583 adult residents in rural areas of Ningbo, China between March and May 2013. The survey used a multi-stage, stratified, cluster sampling method. Data collected included demographics and medical history, anthropometric measurements, blood pressure, blood lipid, and plasma glucose. After at least 10 h of overnight fasting, participants underwent an oral glucose tolerance test (OGTT) to identify pre-diabetes. Univariate and multivariate logistic regression analyses were used to evaluate the associated risk factors for pre-diabetes, and to estimate the effect of interaction between the factors. Results: There were 1307 survey participants having pre-diabetes (28.52%) and the age-standardized prevalence was 30.53%. Multivariate logistic regression results showed that overweight/obesity, hypertension, and higher triglycerides were the risk factors for developing pre-diabetes. There were positive interactions between overweight/obesity and triglycerides, and also between hypertension and triglycerides on the multiplicative scale, suggesting that they synergistically influenced the development of pre-diabetes. Conclusions: The rural areas in Ningbo had a high prevalence of pre-diabetes. Overweight and obesity, hypertension, and elevated triglycerides were the major risk factors. There is a need of early intervention for preventing pre-diabetes.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China

Zhao

Lin

Yuan

et al. 2016

IJERPH

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“…Angiotensin II activity is elevated in the circulatory system of hypertension patients, which could be one probable reason. Angiotensin II influences the function of the pancreatic islets by activating the renin-angiotensin-aldosterone system, resulting in islet fibrosis and reduced insulin production, ultimately leading to insulin resistance [ 63 , 64 ].…”

Section: Discussionmentioning

confidence: 99%

The magnitude of undiagnosed diabetes mellitus, prediabetes, and associated factors among adults living in Debre Tabor town, northcentral Ethiopia: A community-based cross-sectional study

Damtie

Workineh

Berhan

et al. 2023

Heliyon

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“…A possible mechanism is that the activity of angiotensin II is increased in the circulatory system of patient with hypertension. Angiotensin II activates renin-angiotensin-aldosterone system and affects the function of the pancreatic islets, resulting in islet fibrosis and reduced synthesis of insulin, and ultimately leading to insulin resistance [57,58]. Insulin resistance can also aggravate the condition of hypertension.…”

Section: Discussionmentioning

confidence: 99%

Associated Risk Factors in Pre-diabetes and Type 2 Diabetes in Saudi Community

Aljabri

Bokhari

Alshareef

et al. 2018

ADO

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Background and Objective: The prevalence and incidence of type 2 diabetes mellitus (T2DM) are increasing worldwide. Pre diabetes is a high-risk state for the development of diabetes and its associated complications. This study aims to determine the associated risk factors among T2DM and pre diabetes patients among adult Saudi population.Methods: For the present study, we analyzed participants who are older than 20 years old and had undergone a blood test to assess HbA1c. A total of 1095 were selected to be enrolled for the present study. All patients were from the population of the Primary health and Diabetic Centres at King Fahad Armed Forces Hospital. Participants were defined as having T2DM according to self-report, clinical reports, use of anti diabetic agents and HbA1c (≥6.5). Non T2DM participants were divided into normoglycemic or pre diabetic group as follows: HbA1c < 5.7, (normoglycemic) or HbA1c 5.7-6.4 (pre diabetes). Laboratory assessments included HbA1c, lipids, creatinine and urinary micro albumin.Main results: Of the 1095 participants analyzed, 796 were women (72.7%). Age was 45.1±11.1 and BMI was 30.7±5.7. Hypertension had been diagnosed in 415 (38.2%) participants. Blood measurements revealed the following values: creatinine 68.2±22.0umol/L , Urine micro albumin (g/min) 55.4±200.3, total cholesterol levels 4.9±1.0mmol/L, high density lipoprotein 1.3±0.3mmol/L, triglyceride levels 1.5±0.7 and low density lipoprotein 3.0±0.9mmol/L. Of the overall 1095 analyzed participants, pre diabetes was present in 362(33.1%), 368(33.6%) were classified as T2DM and 365 (33.3%) as normoglycemic. When comparing pre diabetic with normoglycemic and T2DM population, pre diabetic subjects were more likely to have hypertension and higher triglyceride than normoglycemic but less than T2DM subjects. In addition, pre diabetic patients compared with T2DM ones had higher levels of low density lipoprotein and high density lipoprotein. Logistic regression analysis showed no significant association of any of the co variables with normoglycemic subjects in front of the pre diabetic reference group, whereas the odds of being in the diabetic group gets multiplied by 7.56 for each unitary increase in male gender (p< 0.0001, OR: 7.56, 95% CI 3.16-18.23). Also, individuals with hypertension had higher odds of being in the DM group than in the prediabetic (p<0 .0001, OR: 6.06, 95% CI 3. 25-11.28). Age of subjects had lower odds of being in the DM group than in the pre diabetic (p<0 .0001, OR: 0.85, 95% CI (0.82-0.89). Conclusion:This study found the major clinical differences between pre diabetic and T2DM Patients were the higher hypertension and hypertriglyceridenia in the T2DM patients. Clearly, despite the small sample size, this study has posed important public health issues that require immediate attention from the health authority. Unless immediate steps are taken to contain the increasing prevalence of obesity, diabetes, pre diabetes, the health care costs for chronic diseases will pose an enormous financial burden to the coun...

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Effect of chronic hypoxia on glutathione status and membrane integrity in the pancreas

Cited by 13 publications

References 38 publications

Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China

Prevalence of Pre-Diabetes and Its Associated Risk Factors in Rural Areas of Ningbo, China

The magnitude of undiagnosed diabetes mellitus, prediabetes, and associated factors among adults living in Debre Tabor town, northcentral Ethiopia: A community-based cross-sectional study

Associated Risk Factors in Pre-diabetes and Type 2 Diabetes in Saudi Community

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