Effect of Chronic Emotional and Pain Stress on Histone H3 Phosphorylation in the Hippocampus of Rat Strains with Different Excitability of the Nervous System

Abstract

Long-term effects of chronic emotional and pain stress on histone H3 phosphorylation by serine 10 in hippocampal CA3 neurons were examined 24 h, 2 weeks, and 2 months after termination of the stress procedure in 2 rat strains differing by excitability of the nervous system. The low excitable rats with high threshold (HT) of excitability were characterized by a high baseline level of histone H3 phosphorylation in comparison with the high excitable rats with low threshold (LT) of excitability. The long-term emotional and pain stress significantly changed the number of positive immune cells in highly excitable rats: this parameter increased in 24 h and 2 weeks after the stress, but returned to the control level in 2 months. In contrast, stress did not affect histone H3 phosphorylation in low excitable rats. Thus, long-term (up to 2 weeks) changes in histone H3 phosphorylation were reveled in rat hippocampal CA3 neurons, which depended on genetically determined functional status of the nervous system.

Race, Ethnicity, Family Socioeconomic Status, and Children’s Hippocampus Volume

“…J. Kim et al, 2019;Lawson et al, 2017;Noble, Houston, Kan, & Sowell, 2012;Staff et al, 2012). The hippocampus, a medial temporal lobe structure, is involved in forming memories (Gerges, Alzoubi, Park, Diamond, & Alkadhi, 2004;Hanson, Chandra, Wolfe, & Pollak, 2011;Narayanan & Chattarji, 2010;Nelson et al, 2003;Zahodne, Schupf, & Brickman, 2018), learning (Chozick, 1983;Fischer, Nyberg, & Backman, 2010;Hair, Hanson, Wolfe, & Pollak, 2015;Hu et al, 2016;Magarinos, Verdugo, & McEwen, 1997), emotions (Chang, Hsiao, Chen, Yu, & Gean, 2015;Pavlova, Savenko, Dyuzhikova, Shiryaeva, & Vaido, 2012;Poeggel et al, 2003), and social relations (Rubin, Watson, Duff, & Cohen, 2014). Altered size and function of the hippocampus is shown in post-traumatic stress disorder (PTSD) (Ahmed-Leitao et al, 2019;Filipovic et al, 2011;Jin et al, 2014; E. J.…”