Effect of Chronic Anal Fissure Components on Isosorbide Dinitrate Treatment

Abstract

Chronic anal fissure components should be considered when evaluating the success rates of studies reporting the results of various medical treatments. The number of components seems to be an important factor that affects the results of isosorbide dinitrate treatment.

Comparison of Lateral Internal Sphincterotomy with Topical Nitroglycerine Treatment in Patients with Chronic Anal Fissure: A Prospective Randomised Study

“…Components of Chronic Anal Fissure influence the success rates of various medical treatments. In a study by Arslan et al [24] in patients with Chronic Anal Fissure receiving isosorbide dinitrate treatment, success rates were found to be lower in patients with persistant fissure, sentinel skin tag and hypertrophic anal papilla than those in patients with only one or two of these components. Topical nitroglicerin treatment has side effects such as moderately severe transient headache and feeling of burning in anal region.…”

Optimized Synthesis According to One-Step Process of a Biobased Thermoplastic Polyacetal Derived from Isosorbide

“…Isosorbide also known as 1,4:3,6-dianhydro- d -sorbitol is obtained from sugar industry by double dehydration of starch derivatives [24,25]. This rigid, chiral, bicyclic and nontoxic molecule was studied in various fields of applications ranging from polymers [26], coating [27,28], surfactant [29,30,31,32], catalysis [33], textile [34], semi finite materials obtained from click chemistry [35,36] (i.e., prepregs) including plasticizers [37,38,39,40] to pharmaceuticals [41,42,43] or biomedical field [44,45]. The difference between isosorbide (IS) in comparison to its two isomers [24] isoidide (II) and isomannide (IM) is the configuration of the two hydroxyl groups as shown in Figure 2.…”