Effect of chronic administration with human thioredoxin‐1 transplastomic lettuce on diabetic mice

Watanabe, Rie; Ashida, Hiroshi; Kobayashi-Miura, Mikiko; Yokota, Akiho; Yodoi, Junji

doi:10.1002/fsn3.2391

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Human metagenome-wide association studies in patients with type 2 diabetes demonstrated highly significant correlations between hyperglycemia and IR and specific intestinal bacteria, bacterial genes, and associated metabolic pathways [ 68 ]. Hyperglycemia affects goblet cell proliferation, maturation, and mucus biosynthesis, which will disrupt the intestinal barrier and intestinal mucus, allowing pathogenic bacteria and their elements, such as LPS, to pass through the epithelial barrier [ 69 , 70 ]. Subsequently, LPS binds to toll-like receptors on the surface of intestinal epithelial cells to recruit immune cells in the intestine [ 67 , 71 ].…”

Section: Gdm–gut Interactionmentioning

confidence: 99%

Gut Microbiota and Critical Metabolites: Potential Target in Preventing Gestational Diabetes Mellitus?

Liu

Geng

et al. 2023

Microorganisms

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Gestational diabetes mellitus (GDM) is an intractable issue that negatively impacts the quality of pregnancy. The incidence of GDM is on the rise, becoming a major health burden for both mothers and children. However, the specific etiology and pathophysiology of GDM remain unknown. Recently, the importance of gut microbiota and related metabolic molecules has gained prominence. Studies have indicated that women with GDM have significantly distinct gut microbiota and gut metabolites than healthy pregnant women. Given that the metabolic pathways of gut flora and related metabolites have a substantial impact on inflammation, insulin signaling, glucose, and lipid metabolism, and so on, gut microbiota or its metabolites, such as short-chain fatty acids, may play a significant role in both pathogenesis and progression of GDM. Whereas the role of intestinal flora during pregnancy is still in its infancy, this review aims to summarize the effects and mechanisms of gut microbiota and related metabolic molecules involved in GDM, thus providing potential intervention targets.

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Section: Gdm–gut Interactionmentioning

confidence: 99%

Gut Microbiota and Critical Metabolites: Potential Target in Preventing Gestational Diabetes Mellitus?

Liu

Geng

et al. 2023

Microorganisms

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A Review on the Efficacy of Plant-derived Bio-active Compounds Curcumin and Aged Garlic Extract in Modulating Cancer and Age-related Diseases

Banerjee

Das

Murhekar

et al. 2024

CRCEP

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Aging is a process characterized by accumulating degenerative changes resulting in the death of an organism. Aging is mediated by various pathways that are directly linked to the individual's lifespan and are shunted for many age-related diseases. Many strategies for alleviating age-related diseases have been studied, which can target cells and molecules. Modern drugs such as Metformin, Rapamycin, and other drugs are used to reduce the effects of age-related diseases. Despite their beneficial activity, they possess some side effects which can limit their applications, mainly in older adults. Natural phytochemicals which have anti-aging activities have been studied by many researchers from a broader aspect and suggested that plant-based compounds can be a possible, direct, and practical way to treat age-related diseases which has enormous anti-aging activity. Also, studies indicated that the synergistic action of phytochemicals might enhance the biological effect rather than the individual or summative effects of natural compounds. Curcumin has an antioxidant property and is an effective scavenger of reactive oxygen species. Curcumin also has a beneficial role in many age-related diseases like diabetes, cardiovascular disease, neurological disorder, and cancer. Aged garlic extracts are also another bioactive component that has high antioxidant properties. Many studies demonstrated aged garlic extract, which has high antioxidant properties, could play a significant role in anti-aging and age-related diseases. The synergistic effect of these compounds can decrease the requirement of doses of a single drug, thus reducing its side effects caused by increased concentration of the single drug.

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Effect of chronic administration with human thioredoxin‐1 transplastomic lettuce on diabetic mice

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 2 publications

References 49 publications

Gut Microbiota and Critical Metabolites: Potential Target in Preventing Gestational Diabetes Mellitus?

Gut Microbiota and Critical Metabolites: Potential Target in Preventing Gestational Diabetes Mellitus?

A Review on the Efficacy of Plant-derived Bio-active Compounds Curcumin and Aged Garlic Extract in Modulating Cancer and Age-related Diseases

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