Effect of chronic administration of <i>Boerhaavia diffusa</i> Linn. leaf extract on experimental diabetes in rats

Phytochemical screening and in vitro bioactivities of the extracts of aerial part of Boerhavia diffusa Linn.

“…Stock solutions of the samples were prepared by dissolving required amount of extracts in specific volume of pure DMSO: dimethyl sulfoxide (Merck, Germany). 4 mL of seawater was given to each of the vials. Then specific volume of sample was transferred from the stock solution to the vials to get final sample concentrations of 50 to 400 毺g/mL.…”

“…The root and the whole plant of B. diffusa are used in traditional medicine for the treatment of diabetes, stress, dyspepsia, abdominal pain, inflammation, jaundice, enlargement of spleen, heart diseases, bacterial infections [4,5] and impotence [2] . It has also been reported to be useful in the treatment of elephantiasis, night blindness, corneal ulcers, various hepatic disorders and as an antiviral agent [5,6] .…”

“…Pharmacological studies have demonstrated that B. diffusa known to possess anticonvulsant [4] , diuretic, anti-inflammatory, antifibrinolytic [9] , antibacterial [10] , anti-hepatotoxic, anthelmintic, febrifuge, anti-leprosy, antiasthmatic, antiurethritis, antilymphoproliferative [11] , antimetastatic [12] , immunosuppressive [13] , antidiabetic, antioxidant [14] , immune-modulation [15] , hepatoprotective [16] , anti-nociceptive, nephroprotective [17] , bacteria induced ulcer & diarrhea [18] and antiurolithiatic [19] activities. The identification of phytoconstituents and assay of antioxidant, thrombolytic, cytotoxic, antimicrobial activities were conducted using specific standard in vitro procedures.…”

An Update Review on Ethnomedicinal, Phytochemical and Pharmacological Profile of genus Boerhavia

“…The results indicate that the reduction in blood glucose produced by the extract is probably through rejuvenation of pancreatic β-cells or through extra pancreatic action. Thus the chloroform extract of B. diffusa has significant antidiabetic activity [64]. Ethanolic extract of roots of Boerhavia Diffusa has antidiabetic potential and significantly reduced Total Cholesterol, Triglycerides, VLDL, and LDL with an increase in HDL which is having a protective function for the heart compared with diabetic control group.…”

Punarnava (Boerhaavia Diffusa Linn.): A Comprehensive Review

“…The effect was more prominent than glibenclamide. [67] Anticonvulsant activity Study showed the crude methanolic extract of B. diffusa and its liriodendrin-rich fraction showed a dose-dependent protection against PTZ-induced convulsions.…”