Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies

Akison, Lisa K.; Kuo, Jenny; Reid, Natasha; Boyd, Roslyn N.

doi:10.1111/acer.13817

Cited by 37 publications

(32 citation statements)

References 86 publications

(179 reference statements)

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“…In pregnancy, higher frequencies and amounts of binge drinking have also been reported than in nonpregnant women [135]. From the evidence-base, it is increasingly apparent that choline can attenuate some of the neurological damage associated with fetal alcohol syndrome [31,98,99,[101][102][103][104]113,119,129]. Women need to be better informed that there is no known safe level of alcohol consumption when they might be or are pregnant.…”

Section: Discussionmentioning

confidence: 99%

“…Data from animal models show that higher intakes of choline during gestation and the perinatal period can protect against brain damage and cognitive/neurological declines associated with epilepsy and certain hereditary conditions, such as Down Syndrome and Rett Syndromes [30]. Additionally, a review collating evidence from 22 human clinical and preclinical studies concluded that choline supplementation has the potential to ameliorate some of the behavioral, cognitive, and neurological deficits observed in offspring exposed to alcohol in utero [31].…”

Section: Functionsmentioning

confidence: 99%

“…There has been an emergence of interest in terms of how choline influences neurodevelopment and brain function. A large body of evidence has evolved over the last few decades from both animal studies and clinical trials [31,42,43,69]. From a health stance, in 2011, EFSA approved several claims for choline, including that choline consumption can: "contribute to normal lipid metabolism", "maintain normal liver functioning", and "contribute to normal homocysteine levels" [70].…”

Section: Choline Knowledge Gapsmentioning

confidence: 99%

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Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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The foundations of neurodevelopment across an individual’s lifespan are established in the first 1000 days of life (2 years). During this period an adequate supply of nutrients are essential for proper neurodevelopment and lifelong brain function. Of these, evidence for choline has been building but has not been widely collated using systematic approaches. Therefore, a systematic review was performed to identify the animal and human studies looking at inter-relationships between choline, neurological development, and brain function during the first 1000 days of life. The database PubMed was used, and reference lists were searched. In total, 813 publications were subject to the title/abstract review, and 38 animal and 16 human studies were included after evaluation. Findings suggest that supplementing the maternal or child’s diet with choline over the first 1000 days of life could subsequently: (1) support normal brain development (animal and human evidence), (2) protect against neural and metabolic insults, particularly when the fetus is exposed to alcohol (animal and human evidence), and (3) improve neural and cognitive functioning (animal evidence). Overall, most offspring would benefit from increased choline supply during the first 1000 days of life, particularly in relation to helping facilitate normal brain development. Health policies and guidelines should consider re-evaluation to help communicate and impart potential choline benefits through diet and/or supplementation approaches across this critical life stage.

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Section: Discussionmentioning

confidence: 99%

Section: Functionsmentioning

confidence: 99%

Section: Choline Knowledge Gapsmentioning

confidence: 99%

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Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Derbyshire

Obeid

2020

Nutrients

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“…One potential explanation for this finding is that guidelines and standards for multicenter studies are just emerging, and there has yet to be any reporting recommendations specific to a preclinical multicenter design. Nonetheless, compared to previous reporting assessments of single-centered preclinical studies [32, 33], the completeness of reporting for the twelve preclinical multicenter studies was appreciably higher.…”

Section: Discussionmentioning

confidence: 55%

Multicenter preclinical studies as an innovative method to enhance translation: a systematic review of published studies

Hunniford

Grudniewicz

Fergusson

et al. 2019

Preprint

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Multicenter preclinical studies have been suggested as a method to improve reproducibility, generalizability and potential clinical translation of preclinical work. In these studies, multiple independent laboratories collaboratively conduct a research experiment using a shared protocol. The use of a multicenter design in preclinical experimentation is a recent approach and only a handful of preclinical multicenter studies have been published. Here, we systematically identify, assess and synthesize published preclinical multicenter studies investigating interventions using in vivo models. Synthesized data included study methods/design, basic characteristics, outcomes, and barriers and facilitators. Study risk of bias, completeness of reporting and the degree of collaboration were evaluated using established methods. The database searches identified 3095 citations and 12 studies met inclusion criteria. The multicenter study design was applied across a diverse range of diseases including stroke, heart attack, traumatic brain injury, and diabetes. The median number of centers was 4 (range 2-6) and the median sample size was 135 (range 23-384). Most studies had lower risk of bias and higher completeness of reporting than typically seen in single-centered studies. Only four of the twelve studies produced results consistent with previous single-center studies, highlighting a central concern of preclinical research: irreproducibility and poor generalizability of findings from single laboratories. Our review suggests that multicenter preclinical studies may provide a method to robustly assess therapies prior to considering clinical translation. Registered with PROSPERO CRD42018093986.

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“…It also results in epigenetic modifications, altered preimplantation embryo development and placental function (Kalisch-Smith and Moritz 2018). A recent systematic review of clinical and preclinical studies indicates that dietary supplementation with choline partially reverses the effects of alcohol on offspring health (Akison et al 2018). The concentration of alcohol and altered milieu experienced by the gametes and the early preimplantation embryo in the reproductive tract requires further investigation such that appropriate models can be developed to interrogate the effectiveness of novel interventions (Kalisch-Smith and Moritz 2018).…”

Section: Speakers: Mary Wlodek Michelle Lane Patrick Western Karenmentioning

confidence: 99%

Fifty years of reproductive biology in Australia: highlights from the 50th Annual Meeting of the Society for Reproductive Biology (SRB)

Bromfield

Dowland

Dunleavy

et al. 2019

Reprod. Fertil. Dev.

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The 2018 edition of the Society for Reproductive Biology’s (SRB) Annual Meeting was a celebration of 50 years of Australian research into reproductive biology. The past 50 years has seen many important contributions to this field, and these advances have led to changes in practice and policy, improvements in the efficiency of animal reproduction and improved health outcomes. This conference review delivers a dedicated summary of the symposia, discussing emerging concepts, raising new questions and proposing directions forward. Notably, the symposia discussed in this review emphasised the impact that reproductive research can have on quality of life and the health trajectories of individuals. The breadth of the research discussed encompasses the central regulation of fertility and cyclicity, life course health and how the environment of gametes and embryos can affect subsequent generations, significant advances in our understanding of placental biology and pregnancy disorders and the implications of assisted reproductive technologies on population health. The importance of a reliable food supply and protection of endangered species is also discussed. The research covered at SRB’s 2018 meeting not only recognised the important contributions of its members over the past 50 years, but also highlighted key findings and avenues for innovation moving forward that will enable the SRB to continue making significant contributions for the next 50 years.

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Effect of Choline Supplementation on Neurological, Cognitive, and Behavioral Outcomes in Offspring Arising from Alcohol Exposure During Development: A Quantitative Systematic Review of Clinical and Preclinical Studies

Cited by 37 publications

References 86 publications

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Choline, Neurological Development and Brain Function: A Systematic Review Focusing on the First 1000 Days

Multicenter preclinical studies as an innovative method to enhance translation: a systematic review of published studies

Fifty years of reproductive biology in Australia: highlights from the 50th Annual Meeting of the Society for Reproductive Biology (SRB)

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