1997
DOI: 10.1016/s0022-2275(20)37441-1
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Effect of cholesterol on apolipoprotein A-I binding to lipid bilayers and emulsions

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Cited by 58 publications
(39 citation statements)
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“…The unique properties are often found in biological systems. Phospholipids are, for example, known to form stable bilayers, which construct cell walls. The physical property and function of the bilayers often reflect molecular structural differences particularly found in the vicinity of the headgroup of the phospholipid, while they also reflect the chain length of hydrocarbon chains in the phospholipid.…”
Section: Introductionmentioning
confidence: 99%
“…The unique properties are often found in biological systems. Phospholipids are, for example, known to form stable bilayers, which construct cell walls. The physical property and function of the bilayers often reflect molecular structural differences particularly found in the vicinity of the headgroup of the phospholipid, while they also reflect the chain length of hydrocarbon chains in the phospholipid.…”
Section: Introductionmentioning
confidence: 99%
“…Consequently, the yellow arrow pointed out the colocalization of green and red fluorescence for RGD-HDL/FAM-Ch-siRNA proving that the intracellular pathway of RGD-HDL nanoparticles was indeed through RGD-related endocytosis, and the endolysosomal escape arisen from the proton sponge effect ensured the efficient cytoplasmic release of Ch-siRNA. Moreover, the cyclic-RGDyk modified amphiphilic apoA-I may also contribute to the escape by binding to the bilayer lipid membranes of endolysosomes. , Previous studies confirmed that siRNA delivery mediated by HDL involved the direct cytoplasmic delivery through SR-BI, thereby bypassing endolysosomal trapping . After apoA-I recognized and bound to SR-BI at the cell surface, subsequent steps including removal of siRNA from nanoparticles, and selective absorption into cells while leaving apoA-I behind, resulted in disadvantages of siRNA wastage and delivery efficiency compromise.…”
Section: Resultsmentioning
confidence: 99%
“…Moreover, the cyclic-RGDyk modified amphiphilic apoA-I may also contribute to the escape by binding to the bilayer lipid membranes of endolysosomes. 47,48 Previous studies confirmed that siRNA delivery mediated by HDL involved the direct cytoplasmic delivery through SR-BI, thereby bypassing endolysosomal trapping. 49 After apoA-I recognized and bound to SR-BI at the cell surface, subsequent steps including removal of siRNA from nanoparticles, and selective absorption into cells while leaving apoA-I behind, resulted in disadvantages of siRNA wastage and delivery efficiency compromise.…”
Section: Stability Protonmentioning
confidence: 96%
“…The differences in surface lipid composition of plasma lipoproteins are probably important factors influencing their metabolic fates in animal plasma. We have previously shown that the surface composition of lipid emulsions affects the binding of apolipoproteins to the particle surface (9,10) and their metabolism in rats (11). The major lipid constituents of plasma lipoprotein surface are phosphatidylcholine (PC), sphingomyelin (SM), and unesterified cholesterol (Chol).…”
mentioning
confidence: 99%
“…Further, the influence of Chol on lipoprotein metabolism remains to be fully clarified. We have shown that Chol regulates mobility of the surface layers and consequently influences apoli-poprotein binding to the surface (9,10). We presumed that the composition of the emulsion surface plays a crucial role in lipoprotein metabolism, in particular, in LPL-mediated lipolysis.…”
mentioning
confidence: 99%