Effect of cholecystectomy on bile acid metabolism and serum lipoprotein profiles

Moussavian, Cyrus A.; Parhofer, Klaus G.; Juengst, Dieter

doi:10.1016/s0016-5085(00)85675-9

Cited by 2 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Levels of C4, which is a marker of bile acid synthesis, tend to increase after cholecystectomy thus reflecting increased synthesis postoperatively. 34 37 Fibroblast growth factor 19 (FGF19) and C4 levels show significant daily changes and peak at noon, however, after cholecystectomy, this diurnal rhythm changes and FGF19 levels are significantly less at noon, declining at 3 months after surgery. FGF19 levels were shown to correlate to Bile acids (BA) synthesis as measured by C4 levels prior to surgery, but this correlation was lost after cholecystectomy.…”

Section: Discussionmentioning

confidence: 99%

“…Orocaecal transit has been shown to increase after cholecystectomy,7 32 as is colonic transit though this remains technically within normal limits 7. In some cases, though patients did not report diarrhoea after cholecystectomy, they did report an increase in bowel movements and fewer formed stools 33 34. The investigators did not always define what they meant by diarrhoea in a standardised manner (such as number of episodes per day and the use of the Bristol stool chart) and some divided it into ‘mild’ and ‘severe’, again without defining what classifies patients into these divisions 23.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Postcholecystectomy diarrhoea rate and predictive factors: a systematic review of the literature

et al. 2022

View full text Add to dashboard Cite

ObjectivesCholecystectomy is one of the most common surgical procedures performed worldwide to treat gallstone-related disease. Postcholecystectomy diarrhoea (PCD) is a well-reported phenomenon, however, the actual rate, predictive factors and mechanism of action have not been well determined. A systematic review was undertaken to determine the rate and predictive factors associated with diarrhoea in the postcholecystectomy setting.MethodsThe review was conducted according to the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocol. Databases searched included Medline, Embase, Pubmed, Cochrane and Google Scholar up to 29 September 2020. The inclusion criteria consisted of cohort studies or randomised trials which investigated the rate of PCD and predictive factors. Case reports, case series, conference abstracts and expert opinion pieces were excluded as were other systematic reviews as all the original articles from those reviews were included in this review. Papers that did not include PCD as a separate entity were excluded. Bias assessment was performed using the Newcastle-Ottawa Scale for cohort studies and the Cochrane risk of bias tool for randomised controlled trials as appropriate. Data were extracted by two authors (AF and JAA) and an overall rate of PCD was calculated. Predictive factors were also extracted and compared between studies.Results1204 papers were obtained and 21 were found to contain relevant information about PCD, including the number of patients developing diarrhoea, method of symptom assessment and time of onset postcholecystectomy. A pooled total of 3476 patients were included across the identified studies with 462 (13.3%) patients developing PCD. Possible predictive factors varied across all studies, with characteristics such as gender, age and weight of patients postulated as being predictive of PCD, with no agreement across studies.DiscussionPCD is therefore relatively common (13.3%). This has important implications for patient consent. Patients ought to be investigated early for bile acid diarrhoea in suspected PCD. More studies are required to determine the possible predictive factors for PCD. Limitations of the study included that most studies were not powered for calculation of PCD, and assessment methods between studies varied.PROSPERO registration numberCRD42019140444.

show abstract

Section: Discussionmentioning

confidence: 99%