Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study

Borup, Christian; Hedbäck, Nora; Wildt, Signe; Rumessen, Jüri Johannes; Bouchelouche, Pierre; Gauliard, Emilie; Rainteau, Dominique; Munck, Lars Kristian

doi:10.1002/ygh2.489

Cited by 1 publication

(2 citation statements)

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“…Also, although not following a low‐fat diet was a predictor for diarrhoea at 1 week postlaparoscopic cholecystectomy, this was not the case at 3 months. Furthermore, diarrhoea after cholecystectomy may not be due to excessive colonic bile acid exposure 58 . It is also possible that, in this cohort, chronic diarrhoea could be an as yet undiagnosed condition such as coeliac disease, microscopic colitis, post radiation diarrhoea, small bowel overgrowth, lactose intolerance or fat malabsorption 59 .…”

Section: Discussionmentioning

confidence: 91%

“…Furthermore, diarrhoea after cholecystectomy may not be due to excessive colonic bile acid exposure. 58 It is also possible that, in this cohort, chronic diarrhoea could be an as yet undiagnosed condition such as coeliac disease, microscopic colitis, post radiation diarrhoea, small bowel overgrowth, lactose intolerance or fat malabsorption. 59 Because a diagnosis of BAD in the UK necessitates specialist review, 59 and BAD is confirmed by response to bile acid sequestrant medication, this is unlikely.…”

Section: Discussionmentioning

confidence: 95%

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Food intolerance related to gastrointestinal symptoms amongst adults living with bile acid diarrhoea: A cross‐sectional study

McKenzie,

French,

Todd

et al. 2023

J Human Nutrition Diet

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BackgroundThe role of food in managing bile acid diarrhoea (BAD) is poorly understood. The present study explored the prevalence of food intolerance amongst adults with BAD.MethodsThe study comprised a cross‐sectional survey of adults with BAD determined by the 75selenium homotaurocholic acid test (SeHCAT) living in the UK. Participants anonymously completed an online questionnaire on 39 food items. Frequency of food in general affecting BAD symptoms, as well as frequencies of diarrhoea, abdominal pain, bloating, flatulence and consequential food avoidance after food item ingestion, were assessed. Food group avoidance was also assessed.ResultsThere were 434 participants who completed the questionnaire between April and May 2021 of whom 80% reported moderate to severe chronic diarrhoea. Food intolerances were reported by 88.0% (95% confidence interval [CI] = 84.6–90.9) of participants. Diarrhoea was reported most frequently after take‐away food, fish and chips, creamy sauces, cream and large quantities of fruit (range 41.0%–33.6%). Lowest frequencies were for potato, avocado, mango, watermelon and pear (range 3.7%–7.4%) for the foods listed in the questionnaire. Similar trends were found for abdominal pain, bloating, flatulence and consequential food avoidance. Symptom‐triggering within 30 min of ingestion was more prevalence than after 30 min for almost all foods. Food group avoidance was highest for fatty foods (81.2%; 95% CI = 77.8–85.3) followed by dairy (53.9%; 95% CI = 49.1–58.7).ConclusionsPerceived food intolerance amongst adults with BAD and persisting diarrhoeal symptoms is high. Important triggers were meals with a higher fat content and higher‐fat dairy products. Diets amongst those with persisting diarrhoeal symptoms may be overly restrictive.

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Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 95%

Food intolerance related to gastrointestinal symptoms amongst adults living with bile acid diarrhoea: A cross‐sectional study

McKenzie,

French,

Todd

et al. 2023

J Human Nutrition Diet

View full text Add to dashboard Cite

show abstract

Effect of cholecystectomy on bile acid diarrhoea biomarkers: A prospective clinical study

Abstract: This is an open access article under the terms of the Creat ive Commo ns Attri bution-NonCo mmercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 1 publication

References 41 publications

Food intolerance related to gastrointestinal symptoms amongst adults living with bile acid diarrhoea: A cross‐sectional study

Food intolerance related to gastrointestinal symptoms amongst adults living with bile acid diarrhoea: A cross‐sectional study

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