Effect of chlorinated ethanes and ethylenes on electron transport in rat liver mitochondria.

Takano, Takehito; Miyazaki, Y.

doi:10.2131/jts.7.143

Cited by 6 publications

(1 citation statement)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This carbonyl stress imposed by reactive VOC metabolites damages organelles, therefore contributing to FLD (see also Sections 3 , 5 ). For example, VC and other VOCs such as acrolein, benzene, hexane, toluene, acetaldehyde, formaldehyde and acetone have been shown to damage mitochondria, causing bioenergetic dysfunction and cell damage 89 , 90 , 91 , 92 , 93 . If exposure to VOCs is high enough, this damage and dysfunction can ultimately lead to organ damage.…”

Section: Volatile Organic Compounds and Other Environmental Toxicants As Contributing Factors To Fldmentioning

confidence: 99%

Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

Schnegelberger

Lang

Arteel

et al. 2021

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

Occupational and environmental exposures to industrial chemicals are well known to cause hepatotoxicity and liver injury. However, despite extensive evidence showing that exposure can lead to disease, current research approaches and regulatory policies fail to address the possibility that subtle changes caused by low level exposure to chemicals may also enhance preexisting conditions. In recent years, the conceptual understanding of the contribution of environmental chemicals to liver disease has progressed significantly. Mitochondria are often target of toxicity of environmental toxicants resulting in multisystem disorders involving different cells, tissues, and organs. Here, we review persistent maladaptive changes to mitochondria in response to environmental toxicant exposure as a mechanism of hepatotoxicity. With better understanding of the mechanism(s) and risk factors that mediate the initiation and progression of toxicant-induced liver disease, rational targeted therapy can be developed to better predict risk, as well as to treat or prevent this disease.

show abstract

Section: Volatile Organic Compounds and Other Environmental Toxicants As Contributing Factors To Fldmentioning

confidence: 99%

Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

Schnegelberger

Lang

Arteel

et al. 2021

Acta Pharmaceutica Sinica B

View full text Add to dashboard Cite

show abstract

Fatal intoxication by 1,2-dichloroethane-a case report

NOUCHI

Miura

Kanayama

et al. 1984

Int. Arch Occup Environ Heath

View full text Add to dashboard Cite

This is a case report of acute fatal intoxication after accidental exposure to 1,2-dichloroethane in a 51-year-old man. Clinical manifestations, blood chemistry, and autopsy findings are described. High levels of lactate and ammonia in blood had been observed before the elevation of glutamic transaminases, lactic dehydrogenase, and creatine phosphokinase. Ornithine carbamyl transferase and glutamic oxaloacetic transaminase of mitochondrial origin (m-GOT) were remarkably high.

show abstract

Interaction of trichloroethane isomers with cytochrome P-450 in the perfused rat liver

Takano

Miyazaki

Motohashi

1985

Fundamental and Applied Toxicology

View full text Add to dashboard Cite

Effect of chlorinated ethanes and ethylenes on electron transport in rat liver mitochondria.

Cited by 6 publications

References 17 publications

Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

Environmental toxicant-induced maladaptive mitochondrial changes: A potential unifying mechanism in fatty liver disease?

Fatal intoxication by 1,2-dichloroethane-a case report

Interaction of trichloroethane isomers with cytochrome P-450 in the perfused rat liver

Contact Info

Product

Resources

About