Effect of chlordiazepoxide on stress in rats

Effects of chlordiazepoxide, flumazenil and DMCM on plasma catecholamine and corticosterone concentrations in rats

“…It has previously been shown that handling and intraperitoneal injection of saline results in an enhancement of plasma CS levels in rats (21,27). Furthermore, our CDP effects on plasma CS are in general agreement with several other studies (17,20,31) seen with the use of medium to high, sedative, doses of CDP and not with low doses, it has been suggested that these effects are related to the behaviorally depressant action of CDP (18,31). The lack of significant increases in plasma NA and A contents following handling and intraperitoneal vehicle injection is most likely due to the timing of sample collection.…”

General Pharmacology and Neuropharmacology of Benzodiazepine Derivatives

“…(1979) could prevent the rise of corticosteroids induced by a mild noise stress with diazepam; the drug was, however, ineffective against severe stressors, such as electric foot shock and immobilization. A partial prevention offoot shock-induced elevation of corticosteroids was obtained by KRULIK and CERNY (1971) with both chlordiazepoxide and diazepam. Plasma corticosterone elevation in rats stressed by irregularly signaled foot shock was reduced by diazepam (BASSETT and CAIRN CROSS, 1974).…”

Spontaneous Withdrawal from the Triazolobenzodiazepine Alprazolam Increases Cortical Corticotropin-Releasing Factor mRNA Expression

“…They have been demonstrated to exert a number of effects opposite to those of CRF, including suppression of HPA axis activation (Krulik and Cerny, 1971;Kalogeras et al, 1990;Rohrer et al, 1994, Cowley et al, 1995, as well as to directly antagonize stress-induced CRF transcription and release (Imaki et al, 1995;Pich et al, 1995), and the anxiogenic effects of centrally administered CRF (Britton et al, 1985;Swerdlow et al, 1986;Dunn and File, 1987). Our laboratory has previously shown that chronic treatment with the triazolobenzodiazepine alprazolam in the Sprague Dawley rat produced diametrically opposite effects on the CRF-CRF 1 versus urocortin I-CRF 2 receptor systems.…”