“…They have been demonstrated to exert a number of effects opposite to those of CRF, including suppression of HPA axis activation (Krulik and Cerny, 1971;Kalogeras et al, 1990;Rohrer et al, 1994, Cowley et al, 1995, as well as to directly antagonize stress-induced CRF transcription and release (Imaki et al, 1995;Pich et al, 1995), and the anxiogenic effects of centrally administered CRF (Britton et al, 1985;Swerdlow et al, 1986;Dunn and File, 1987). Our laboratory has previously shown that chronic treatment with the triazolobenzodiazepine alprazolam in the Sprague Dawley rat produced diametrically opposite effects on the CRF-CRF 1 versus urocortin I-CRF 2 receptor systems.…”