Effect of chest wall vibration on the canine diaphragm during breathing

Leduc, Dimitri; Troyer, André De

doi:10.1183/09031936.02.00242702

Cited by 6 publications

(6 citation statements)

References 26 publications

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“…Additionally inspiratory-only vibration induced augmentation in peak inspired Xow whereas inspiratory-only resistance suppressed peak inspired airXow. Results from Gandevia and McCloskey (1976) and Colebatch et al (1977) are similar to our results and may relate to the fact that they used a cushion-type vibration stimulus on the chest that provides non-selective vibration stimulation rather than the focally applied vibration more commonly used (Jammes et al 2000;Leduc et al 2001;Leduc and De Troyer 2002;Leduc and De Troyer 2003). Gandevia and McCloskey (1976) attributed their Wndings to intercostal muscle spindle activation via supraspinal reXex loops rather than non-speciWc stimulation of inspiratory and expiratory muscle receptors.…”

Section: Discussionsupporting

confidence: 86%

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Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration

2009

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To investigate whether 30 breaths performed against a high-frequency airway occlusion stimulus modulates ventilatory control both within-phase (within the phase of breathing that the stimulus was presented) and opposite-phase (in the opposite-phase of breathing to that in which the stimulus was presented) of the respiratory cycle. Ten healthy subjects (3 female, 7 male; 22-44 years old) completed 30 breaths prior to and following 30 inspirations or expirations against a high-frequency occlusion stimulus (youbreathe, Exoscience Ltd., London, UK), pressure-matched resistive loading or resting tidal breathing (no load) presented in a random order. The major findings from this study were that inspiratory-only high-frequency occlusion caused a significant augmentation in peak inspiratory airflow and shortening of expiratory time not observed during corresponding resistance. There were no residual effects of any intervention upon any measured ventilatory variables. High-frequency airway occlusion modulates ventilation both within-phase and in the opposite-phase, effects which are absent following resistive loaded breathing.

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Section: Discussionsupporting

confidence: 86%

“…Furthermore, where external intercostal activity was recorded during expiratory phase vibration, no eVect of vibration was observed (Leduc and De Troyer 2002). These Wndings could be due to species diVerences but also to the fact that the dogs used in Leduc's experiments were unconscious whilst our subjects were awake.…”

Section: Discussionmentioning

confidence: 92%

Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration

2009

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“…These afferents act segmentally (4,5) and at the level of the cortex (13) to drive appropriate EI muscle activity to maintain ventilatory homeostasis. Modulation from reflex pathways between intercostal segments (27) and those involving phrenic and intercostal systems (6,36) further ensure that EI muscle activity is modulated on a breath-by-breath basis. The results from the present study do not allow the evaluation of influences from each of these afferent mechanisms on these conscious animals.…”

Section: Discussionmentioning

confidence: 99%

“…These afferents act segmentally at the spinal cord level and on medullary inspiratory neurons to inhibit inspiratory activity (4,5), and at the level of the cortex (13) may modulate intercostal muscle activity. Reflex connections between thoracic spinal segments (27) involving phrenic and intercostal motor neuronal systems (6,36) have also been identified. Thus intercostal muscle activity is modulated via respiratory muscle afferent feedback on a breath-by-breath basis.…”

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confidence: 99%

Intercostal muscle motor behavior during tracheal occlusion conditioning in conscious rats

Jaiswal

Davenport

2016

Journal of Applied Physiology

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A respiratory load compensation response is characterized by increases in activation of primary respiratory muscles and/or recruitment of accessory respiratory muscles. The contribution of the external intercostal (EI) muscles, which are a primary respiratory muscle group, during normal and loaded breathing remains poorly understood in conscious animals. Consciousness has a significant role on modulation of respiratory activity, as it is required for the integration of behavioral respiratory responses and voluntary control of breathing. Studies of respiratory load compensation have been predominantly focused in anesthetized animals, which make their comparison to conscious load compensation responses challenging. Using our established model of intrinsic transient tracheal occlusions (ITTO), our aim was to evaluate the motor behavior of EI muscles during normal and loaded breathing in conscious rats. We hypothesized that 1) conscious rats exposed to ITTO will recruit the EI muscles with an increased electromyogram (EMG) activation and 2) repeated ITTO for 10 days would potentiate the baseline EMG activity of this muscle in conscious rats. Our results demonstrate that conscious rats exposed to ITTO respond by recruiting the EI muscle with a significantly increased EMG activation. This response to occlusion remained consistent over the 10-day experimental period with little or no effect of repeated ITTO exposure on the baseline ∫EI EMG amplitude activity. The pattern of activation of the EI muscle in response to an ITTO is discussed in detail. The results from the present study demonstrate the importance of EI muscles during unloaded breathing and respiratory load compensation in conscious rats.

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“…Afferent activation of intercostal muscles by vibratory stimulation in humans does not affect dyspnea induced by hypercapnic stimulation, but reduces dyspnea without changes in motor output, when hypercapnic stimulation is associated with inspiratory load (19). Likewise, vibration does not affect the activity of phrenic or medullary neurons in the experimental animal (13,32). These data suggest that cortical drive and dyspnea perception do not necessarily parallel.…”

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confidence: 89%

Effect of limb muscle fatigue on perception of respiratory effort in healthy subjects

Grippo

Carrai

Chiti³

et al. 2010

Journal of Applied Physiology

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The role of nonrespiratory peripheral afferents in dyspnea perception has not been fully elucidated yet. Our hypothesis is that fatigue-induced activation of limb muscle metaboreceptors served by group IV fine afferent fibers may impact on respiratory effort perception. We studied 12 healthy subjects breathing against progressive inspiratory resistive loads (10, 18, 30, 40, and 90 cmH(2)O x l(-1) x s) before and after inducing low-frequency fatigue of quadriceps muscle by repeating sustained contractions at > or = 80% of maximal voluntary contraction. Subjects also underwent a sham protocol while performing two loaded breathing runs without muscle fatigue in between. During the loaded breathing, while subjects mimicked the quiet breathing pattern using a visual feedback, ventilation, tidal volume, respiratory frequency, pleural pressure swings, arterial oxygen saturation, end-tidal partial pressure of CO(2), and dyspnea by a Borg scale were recorded. Compared with prefatigue, limb muscle fatigue resulted in a higher increase in respiratory effort perception for any given ventilation, tidal volume, respiratory frequency, pleural pressure swings, end-tidal partial pressure of CO(2), and arterial oxygen saturation. No difference between the two runs was observed with the sham protocol. The present data support the hypothesis that fatigue of limb muscles increases respiratory effort perception associated with loaded breathing, likely by the activation of limb muscle metaboreceptors.

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Effect of chest wall vibration on the canine diaphragm during breathing

Cited by 6 publications

References 26 publications

Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration

Respiratory modulation in response to high-frequency airway occlusion delivered during inspiration or expiration

Intercostal muscle motor behavior during tracheal occlusion conditioning in conscious rats

Effect of limb muscle fatigue on perception of respiratory effort in healthy subjects

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