Effect of chemically induced osteogenesis supplements on multicellular behavior of osteocytic spheroids

Kim, Jeonghyun; Inagaki, Tadashi; Sunaga, Junko; Adachi, Taiji; Matsumotο, Takeo

doi:10.1016/j.bbrc.2022.07.026

Cited by 1 publication

(2 citation statements)

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“…These modules are then further assembled into 3D structures according to a specific spatial arrangement. The MoA platform is versatile, flexible, and scalable, bridging the gaps between techniques currently employed for building vascularized organotypic tissues to be used for tissue engineering and regenerative medicine [40][41][42][43][44][45][46]. Nowadays, tissue modules of different profiles with regard to type, size, cell composition, and morphology can be prepared (figure 1).…”

Section: Introductionmentioning

confidence: 99%

“…multi-organ systems, organ-scale tissues, and advanced tissues. Compared to conventional cell-assembly methods for vascularized organotypic tissue construction, this approach has the following advantages [40][41][42][43][44][45][46]. First, the cell density is close to that in vivo; second, this approach accelerates the formation of a vascular network and markedly improves vascular maturation; third, the vascular network interacts with other components within the microenvironment and fosters adaptive remodeling; fourth, it significantly improves tissue survival and development.…”

Section: Introductionmentioning

confidence: 99%

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Engineering vascularized organotypic tissues via module assembly

Zhou,

Liu,

Guo

et al. 2023

Int. J. Extrem. Manuf.

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Adequate vascularization is a critical determinant for the successful construction and clinical implementation of complex organotypic tissue models. Currently, low cell and vessel density and insufficient vascular maturation make vascularized organotypic tissue construction difficult, greatly limiting its use in tissue engineering and regenerative medicine. To address these limitations, recent studies have adopted pre-vascularized microtissue assembly for the rapid generation of functional tissue analogs with dense vascular networks and high cell density. In this article, we summarize the development of module assembly-based vascularized organotypic tissue construction and its application in tissue repair and regeneration, organ-scale tissue biomanufacturing, and advanced tissue modeling.

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