Effect of Charcoal Filter on the Emergence from Sevoflurane Anesthesia in a Semi-Closed Rebreathing Circuit

Chang, Dong Jin; Choi, Seung Ho; Choi, Yong Suk; Min, Kyungha

doi:10.3349/ymj.2011.52.4.668

Cited by 4 publications

(4 citation statements)

References 17 publications

(21 reference statements)

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“…The typical volatile anesthetics commonly used nowadays are sevoflurane and desflurane 10-13. Sevoflurane has the potential to adversely affect the kidney function because an inorganic fluoride ion from the defluorination of sevoflurane and compound A from reaction with carbon dioxide absorbent are associated with nephrotoxicity 14,15.…”

Section: Introductionmentioning

confidence: 99%

Kidney Function in Living Donors Undergoing Nephrectomy by Sevoflurane or Desflurane Anesthesia

et al. 2013

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PurposeAlthough there is no clinical evidence of nephrotoxicity with the volatile anesthetics currently used in general anesthesia, a better agent should be needed in terms of preserving postoperative renal function in living kidney donors who have only single remaining kidney. The purpose of the current retrospective, single-center study was to evaluate and compare renal function of living kidney donors after nephrectomy under either sevoflurane or desflurane anesthesia.Materials and MethodsFrom January 2006 through December 2011, a total of 228 donors undergoing video assisted minilaparotomy surgery nephrectomy for kidney donation were retrospectively enrolled in the current study. The donors were categorized into a sevoflurane group or desflurane group based on the type of volatile anesthetic used. We collected laboratory data from the patients preoperatively, immediately after the operation, on the first postoperative day and on the third postoperative day. We also compared renal function of the kidney donors after donor nephrectomy by comparing creatinine level and estimated glomerular filtration rate (eGFR).ResultsThe decrease in renal function after surgery in both groups was the most prominent on the first postoperative day. There were no significant differences between the two groups in postoperative changes of creatinine or eGFR.ConclusionSevoflurane and desflurane can be used safely as volatile anesthetics in donors undergoing nephrectomy.

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Section: Introductionmentioning

confidence: 99%

Kidney Function in Living Donors Undergoing Nephrectomy by Sevoflurane or Desflurane Anesthesia

et al. 2013

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“…It is used for the acute management of poisoning caused by drugs or chemicals [ 6 , 7 , 8 ]. Activated charcoal has been known to adsorb volatile anesthetics, such as ether, trichloroethylene, halothane, methoxyflurane, isoflurane and sevoflurane [ 9 , 10 ]. It is used to adsorb volatile anesthetics in anesthesia research and practice.…”

Section: Discussionmentioning

confidence: 99%

“…As an adsorber, activated charcoal efficiently prevents atmospheric isoflurane contamination during isoflurane sedation [ 11 ]. Recently, the attachment of a charcoal filter to the anesthesia circuit shortened the extubation time and the time to eye opening without adverse effects [ 10 ]. Activated charcoal has been considered and tested in the preparation of anesthesia machines for patients with malignant hyperthermia [ 12 , 13 , 14 ].…”

Section: Discussionmentioning

confidence: 99%

Adsorption of desflurane by the silica gel filters in breathing circuits: an in vitro study

Song

Lim

Ryu

2015

Korean J Anesthesiol

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BackgroundDuring general anesthesia, a heated breathing circuit (HBC) is used to replace the heat and moisture exchange function of the upper airway. One HBC uses an air dryer filter that employs silica gel (SG) as a desiccant. SG is capable of adsorbing many organic compounds. Therefore, we undertook an in vitro study of the adsorption of desflurane by SG filters.MethodsAn HBC was connected to an anesthesia machine, and a test lung was connected to the circuit. The test lung was mechanically ventilated with 2 or 4 L/min of fresh gas flow, with and without the air dryer filter. Desflurane was administered at a 6 vol% on the vaporizer dial setting. The experiment was repeated 15 times in each group. The end-tidal concentrations were measured during the experiments. The air dryer filter weights were measured before and after the experiments, and the times required to achieve the specific end-tidal desflurane concentrations were determined.ResultsSignificant differences in the end-tidal concentrations of desflurane were observed between the control and filter groups (P < 0.001). The filter weights increased significantly after the experiments (P < 0.001). The times required to achieve the same end-tidal desflurane concentrations were different with the application of the air dryer filter (P < 0.001).ConclusionsThe adsorption of desflurane with the use of an air dryer filter was verified in this in vitro study. Careful attention is needed when using air dryer gel filters during general anesthesia.

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“…An artificial lung (5 L reservoir bag) was connected to a breathing circuit system ( Fig. 1 ) of an anesthetic machine (Primus, Dräger Medizintechnik GmbH, Lübeck, Germany) [ 6 ]. The study groups had no filter (a sham group with no anesthetic gas [n = 5] and a control group with anesthetic gas [n = 10]), a bacterial filter (SF 10C, Ace Medical, Seoul, Korea; n = 10) or a viral/bacterial filter (MF 10C, Ace Medical; n = 10) ( Fig.…”

Section: Methodsmentioning

confidence: 99%

Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system

Park

Chung

Moon

et al. 2015

Korean J Anesthesiol

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BackgroundThe aim of this study was to determine whether the end-tidal concentration of desflurane would be affected by a breathing circuit system filter attached at two different positions in anesthetic breathing circuit systems.MethodsAn artificial lung was ventilated under five different conditions. The first group was without any filter or desflurane (n = 5, sham), the second was with desflurane but without any filter (n = 10, control), the third group had a bacterial filter on the expiratory limb (n = 10), and the fourth and fifth groups had a viral/bacterial filter added on the expiratory limb (n = 10) or at the Y-piece of the breathing circuit (n = 10), respectively. In all groups except the sham, administration of 10% desflurane was performed for 5 minutes and then stopped for 5 minutes.ResultsThe mean (SD) end-tidal concentration of desflurane for the groups described above peaked at 0 (0), 9.8 (0.1), 9.8 (0.1), 8.5 (0.1), and 6.7% (0.1) (P < 0.001), respectively. There was no difference in the desflurane concentrations and the expired tidal volume over time between the control and bacterial group, but there was a significant difference between the control and the fourth and fifth groups (P < 0.001).ConclusionsFilters can affect the expiratory desflurane concentration during anesthesia.

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Effect of Charcoal Filter on the Emergence from Sevoflurane Anesthesia in a Semi-Closed Rebreathing Circuit

Cited by 4 publications

References 17 publications

Kidney Function in Living Donors Undergoing Nephrectomy by Sevoflurane or Desflurane Anesthesia

Kidney Function in Living Donors Undergoing Nephrectomy by Sevoflurane or Desflurane Anesthesia

Adsorption of desflurane by the silica gel filters in breathing circuits: an in vitro study

Time course of end-tidal desflurane concentration during delivery and elimination according to the type and location of filters in a semi-closed circuit system

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