Effect of changing metabolic rate on local blood flow control in the canine hindlimb.

Goodman, A. H.; Einstein, Rosemarie; Granger, Harris J.

doi:10.1161/01.res.43.5.769

Cited by 34 publications

(26 citation statements)

References 19 publications

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“…During conditions of increased oxygen consumption, however, the hind-limb P-F relationship is predominantly autoregulatory. These findings support the concept enunciated by Goodman et al (1978), that skeletal REGULATION OF BLOOD FLOW muscle blood flow is not only regulated in accordance with tissue metabolic requirements, but that the precision of blood flow control is also influenced by the metabolic state of the tissue. The finding that autoregulation is readily demonstrable during 'resting' conditions in tissues that normally have a relatively high metabolic rate, such as the heart (Drake-Holland, Laird, Noble, Spaan & Vergroesen, 1984) and brain (Johnson, 1978), also supports this concept.…”

Section: Discussionsupporting

confidence: 85%

“…Other studies also demonstrated that the efficiency of hind-limb autoregulation increased with increases in metabolism (Stainsby, 1962;Jones & Berne, 1964a;Goodman et al 1978;Granger et al 1976). Granger et al (1975) have proposed a two component control system that explains how the efficiency of autoregulation and the rate of metabolism could be coupled.…”

Section: Discussionmentioning

confidence: 99%

“…The reason different investigators have arrived at different conclusions is not entirely clear, but several studies have provided insight into predicting conditions during which autoregulatory behaviour predominates over passive behaviour. Data presented by Stainsby (1962), Jones & Berne (1964 a), and Goodman, Einstein & Granger (1978) demonstrate an enhancement of hind-limb skeletal muscle blood flow autoregulation during conditions that increase oxygen consumption, such as muscular contraction. These observations indirectly support a metabolic mechanism for autoregulation.…”

Section: Introductionmentioning

confidence: 91%

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Autoregulation of hind‐limb blood flow in conscious dogs.

Britton¹,

Metting²,

Ronau³

et al. 1985

The Journal of Physiology

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SUMMARYt. We evaluated the efficiency of blood flow autoregulation of the hind-limb vascular bed of eleven conscious dogs during: (a) resting conditions; (b) graded levels of treadmill exercise; and (c) increases in oxygen consumption produced by the administration of 2,4-dinitrophenol (DNP).2. Blood flow to the left hind limb was measured with an electromagnetic flow probe on the left external iliac artery. Hind-limb perfusion pressure was measured from a catheter in the deep femoral artery and was controlled via an externally inflatable occlusion cuff positioned just distal to the flow probe. Arterial pressure was measured in the abdominal aorta. Experiments were performed 5-16 days after instrumentation.Hind-limb pressure-flow (P-F) relationships were evaluated by decreasing hind-limb perfusion pressure in 4-5 small sequential 'square-wave' steps of 10-15 mmHg each while measuring flow. Each step decrease in perfusion pressure was maintained for 2 min. S. L. BRITTON AND OTHERS6. These data demonstrate that hind-limb blood flow is not autoregulated in resting dogs, but that significant autoregulation is manifest during conditions that increase oxygen consumption. These findings support the general contention that hind-limb blood flow is not only regulated in accordance with tissue metabolic demands, but that the precision of blood flow control is also influenced by the metabolic state of the tissue.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 91%

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Autoregulation of hind‐limb blood flow in conscious dogs.

Britton¹,

Metting²,

Ronau³

et al. 1985

The Journal of Physiology

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“…As in brain, Ca O 2 is a critical variable in these tissues. For example, blood flow to muscle increases nonlinearly with O 2 desaturation and O 2 demand (9). The relatively large but variable increase in skeletal muscle flow (24.5 Ϯ 11.6 ml · min Ϫ 1 · 100 g Ϫ1 ) at 50% O 2 desaturation (Table 4) in the anemic group probably reflects the nonlinear response to Ca O 2 and the interanimal variability in Ca O 2 at this severe level of combined hypoxic and anemic hypoxia.…”

Section: H1940mentioning

confidence: 94%

Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit

Ulatowski

Bucci

Razynska

et al. 1998

American Journal of Physiology-Heart and Circulatory Physiology

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. Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit. Am. J. Physiol. 274 (Heart Circ. Physiol. 43): H1933-H1942, 1998.-We determined whether cerebral blood flow (CBF) remained related to arterial O 2 content (Ca O 2 ) during hypoxic hypoxia when hematocrit and hemoglobin concentration were independently varied with cell-free, tetramerically stabilized hemoglobin transfusion. Three groups of pentobarbital sodium-anesthetized cats were studied with graded reductions in arterial O 2 saturation to 50%: 1) a control group with a hematocrit of 31 Ϯ 1% (mean Ϯ SE; n ϭ 7); 2) an anemia group with a hematocrit of 21 Ϯ 1% that underwent an isovolumic exchange transfusion with an albumin solution (n ϭ 8); and 3) a group transfused with an intramolecularly cross-linked hemoglobin solution to decrease hematocrit to 21 Ϯ 1% (n ϭ 10). Total arterial hemoglobin concentration (g/dl) after hemoglobin transfusion (8.8 Ϯ 0.2) was intermediate between that of the control (10.3 Ϯ 0.3) and albumin (7.2 Ϯ 0.4) groups. Forebrain CBF increased after albumin and hemoglobin transfusion at normoxic O 2 tensions to levels attained at equivalent reductions in Ca O 2 in the control group during graded hypoxia. Over a wide range of arterial O 2 saturation and sagittal sinus PO 2 , CBF remained greater in the albumin group. When CBF was plotted against Ca O 2 for all three groups, a single relationship was formed. Cerebral O 2 transport, O 2 consumption, and fractional O 2 extraction were constant during hypoxia and equivalent among groups. We conclude that CBF remains related to Ca O 2 during hypoxemia when hematocrit is reduced with and without proportional reductions in O 2 -carrying capacity. Thus O 2 transport to the brain is well regulated at a constant level independently of alterations in hematocrit, hemoglobin concentration, and O 2 saturation.anemia; blood; cats; oxygen transport BOTH EXPERIMENTAL (1,6,26,36) and clinical (2,14,15,30,40) anemia result in an increase in cerebral blood flow (CBF) that is inversely related to arterial O 2 content (Ca O 2 ). Because the increase in CBF does not require dilation of large cerebral arteries and pial arterioles (16,19,27,28,41), the passive decrease in viscosity is presumed to be sufficient for adequately decreasing cerebrovascular resistance. Interestingly, the increase in CBF during anemia is approximately the same as the increase in CBF during hypoxic hypoxia at equivalent reductions in Ca O 2 (20). With hypoxic hypoxia, the increase in CBF compensates for the decrease in Ca O 2 , thereby maintaining cerebral O 2 transport (CBF ϫ Ca O 2 ) to the cerebral microcirculation (20, 22, 42). With anemia, cerebral O 2 transport generally is well preserved (1, 16, 20), although small decreases have also been reported (6, 37). Whether preservation of O 2 transport during anemia is the result of active microcirculatory regulation by an O 2 -sensitive mechanism or simply a fortuitous passive effect of decreased hematocrit is unclear.Increases in CBF with meth...

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“…1989. pability. as in adult dogs [3,4], and that blood flow would be redistributed to a work ing limb from the intestinal and renal circu lations. as during induced isometric contrac tion in adult dogs [5] or cats [6].…”

Section: Introductionmentioning

confidence: 99%

Regional Circulatory Responses to Hindlimb Work in Developing Swine

Buckley

Frasier²

1990

Neonatology

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Circulatory effects of hindlimb work were studied in 29 swine (aged 1 day to 1 month) anesthetized with pentobarbital. Femoral, renal and intestinal blood flow, resistance and autoregulatory capability were determined at different levels of hindlimb oxygen consumption before and during distal sciatic nerve stimulation. Increases in oxygen consumption were accompanied by hyperemia at all ages, but by increased oxygen extraction only in 2-week and 1-month-old animals, without evidence of autoregulation. Blood flow was consistently redistributed from the kidney and small intestine only in neonates. Older animals generally sustained autoregulation of renal and intestinal blood flows throughout experiments. We concluded that hindlimb work evokes age-related adjustments in regional blood flow that reflect the balance of neural and autoregulatory control.

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Effect of changing metabolic rate on local blood flow control in the canine hindlimb.

Cited by 34 publications

References 19 publications

Autoregulation of hind‐limb blood flow in conscious dogs.

Autoregulation of hind‐limb blood flow in conscious dogs.

Cerebral blood flow during hypoxic hypoxia with plasma-based hemoglobin at reduced hematocrit

Regional Circulatory Responses to Hindlimb Work in Developing Swine

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