Effect of changes in optic nerve elasticity on central retinal artery blood flow in patients with idiopathic intracranial hypertension

Elsaid, Nada; Belal, Tamer; Batouty, Nihal M.; Razek, Ahmed Abdel Khalek Abdel; Azab, Ahmed

doi:10.1016/j.neurad.2021.06.001

Cited by 4 publications

(1 citation statement)

References 28 publications

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“…1,10,11 This may be attributed to the IIH-associated cascade of events: the increased amount of CSF leads to increased ICP, compressing the ON and resulting in venous congestion, papilledema, and cellular damage. 12,13 The higher MD of the ON in the IIH patients compared to the healthy subjects may be related to decreased cellularity and loss of the cell membrane integrity providing space for free diffusion of water molecules. The lower FA value of the ON in patients versus the healthy subjects may be realted to less anisotropy and weakend water molecule diffusion directions by the presence of edema.…”

Section: Discussionmentioning

confidence: 99%

Diffusion-tensor MR imaging of optic pathway in idiopathic intracranial hypertension

et al. 2023

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Purpose To investigate the role of diffusion tensor imaging (DTI) of optic pathway in patients with idiopathic intracranial hypertension (IIH). Patients and Methods This study included 41 IIH patients and 22 controls. They underwent DTI of the optic nerve (ON) and optic radiation (OR). Their fractional anostrophy (FA) and mean diffusivity (MD) were calculated by two reviewers and correlated with papilledema grade. Results The optic nerve mean FA and MD of patients for reviewer-1 were 0.21 ± 0.047 and 2.189 ± 0.52 ×10−3 mm2/s and for reviewer-2 were 0.216 ± 0.047 and 2.17 ± 0.54 ×10−3 mm2/s. The mean ON FA and MD of controls for reviewer-1 were 0.33 ± 0.048 and 1.29 ± 0.26 ×10−3 mm2/s and for reviewer-2 were 0.34 ± 0.05 and 1.3 ± 0.26 ×10−3 mm2/s. There was significant difference in FA and MD between patients and controls ( p < 0.00001). The OR mean FA and MD of patients for reviewer-1 were 0.61 ± 0.03 and 2.26 ± 0.55 ×10−3 mm2/s and for reviewer-2 were 0.6 ± 0.03 and 2.24 ± 0.57 ×10−3 mm2/s The mean OR FA and MD of controls for reviewer-1 were 0.6 ± 0.03 and 2.19 ± 0.49 ×10−3 mm2/s and for reviewer-2 were 0.6 ± 0.03 and 2.18 ± 0.49 ×10−3 mm2/s. There was no significant difference in FA and MD obtained in patients and controls. Both the FA and the MD of the ON showed strong correlation with the papilledema grade (r = −0.8 and 0.951, respectively). Conclusion Our findings suggest that, IIH is associated mainly with pre-chiasmatic or ON involvement rather than post-chiasmatic parenchymal or OR involvement. DTI MD and FA parameters of the ON may be a reliable imaging biomarker for diagnosis of IIH and well correlated with papilledema grades.

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