Effect of chalcogen bonding interactions on molecular structures; theoretical and crystallographic studies on two palladium(ii) acetate complexes

Abstract

Two palladium complexes, [Pd(L1)(OAc))] (1) and [Pd(L2)(OAc))] (2), have been synthesized by reacting Pd(OAc)2 and the new thioetherazo (HL) ligands (HL = 2(RS)C6H4NH-N=C(COCH3)-SC6H5, R= C6H5 (HL1), CH3 (HL2)). The ligands...

Pd(ii) complexes bearing NNS pincer ligands: unveiling potent cytotoxicity against breast and pancreatic cancer

“…18,19 Recently, palladium complexes bearing NNS donor pincer ligands have been explored due to their chemical stability, electrochemical behaviors, and biological importance. 20 These ligands tend to stabilize metal ions in low oxidation states with exciting physical/chemical properties and geometrical environments. 21 Liangliang Yan et al prepared Pd(II) complexes bearing 8-aminoquinoline-derived NNS donor ligands and tested them against human cervical cancer (HeLa), human mammary cancer (MCF-7), and human lung cancer (A-549) cell lines which showed cytotoxicity similar to that of cisplatin.…”

“…These complexes showed better activity for breast cancer cells (T47D) compared to human colon cancer cells (HCT 116 cell line). 20 To our knowledge, no existing studies have investigated Pd (II) complexes featuring NNS donor pincer ligands against the particularly aggressive breast cancer 4T1 cells and human pan-creatic cancer MIA-PaCa-2 cells. 4T1 is widely used as a tumor model for human breast cancer as it can easily be transplanted into the mammary gland and is described as poorly immunogenic, highly tumorigenic, invasive, and spontaneously metastasizing to distant organs.…”

“…Recently, palladium complexes bearing NNS donor pincer ligands have been explored due to their chemical stability, electrochemical behaviors, and biological importance. 20 These ligands tend to stabilize metal ions in low oxidation states with exciting physical/chemical properties and geometrical environments. 21 Liangliang Yan et al .…”

“…These complexes showed better activity for breast cancer cells (T47D) compared to human colon cancer cells (HCT 116 cell line). 20…”