Effect of Chaihushugan San on expression of the Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase pathway in the hippocampi of perimenopausal rats induced by immobilization stress

Li, Shengqiang; Liang, Wenna; Li, Yachan; Yunlong, Chen; Chen, Shujiao; Li, Candong

doi:10.1016/s0254-6272(15)30123-0

Cited by 3 publications

(4 citation statements)

References 26 publications

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“…To generate a rat model for PMS, the perimenopausal rats were treated with CRS. These rats were considered to be with both KD and LQS ( Li et al, 2015 ; Miao et al, 2018 ). The PMS rats were with a weight loss ( Figure 1A ), decreased sugar preference rate ( Figure 1B ), and reduced level of activity compared to either the 6-month-old or the PM rats without the stress ( Supplementary Figure S3 ).…”

Section: Resultsmentioning

confidence: 99%

“…The diagnosis of traditional Chinese medicine (TCM) is based on symptom-based pattern differentiation (also known as symptom differentiation, Zheng differentiation, pattern diagnosis, and pattern classification) ( Liang et al, 2009 ; Liang et al, 2011 ; Li et al, 2015 ). Over the centuries of TCM practice, PMS is diagnosed as kidney deficiency (KD), a jargonistic term for the debility of bodily functions and loss of vitality, from senescence.…”

Section: Introductionmentioning

confidence: 99%

“…The symptoms of hot flash, night sweat, insomnia, depression, irritability, fatigue, and cognitive impairment, which occur frequently in women suffering PMS, are compatible with those of liver qi stagnation (LQS), a diagnostic designation for illness correlated with anxiety and stress in pattern differentiation ( Liang et al, 2010 ; Yu et al, 2018 ). There were demonstrations that prescriptions of decoctions for LQS were efficacious for treating PMS ( Liang et al, 2010 ; Chen et al, 2014 ; Li et al, 2014 ; Li et al, 2015 ). For better prescription to treat PMS, it is important to investigate the physiological parameters for treating PMS as either KD, LQS, or a combination of both.…”

Section: Introductionmentioning

confidence: 99%

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An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

Lan

Liang

et al. 2021

Front. Pharmacol.

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Ethnopharmacological relevance: Two types of traditional Chinese formulas of botanical drugs are prescribed for treating perimenopausal syndrome (PMS), a disorder in middle-aged women during their transition to menopause. One is for treating PMS as kidney deficiency (KD) due to senescence and declining reproductive functions, and the other is for treating it as liver qi stagnation (LQS) in association with stress and anxiety. Despite the time-tested prescriptions, an objective attestation to the effectiveness of the traditional Chinese treatment of PMS is still to be established and the associated molecular mechanism is still to be investigated.Materials and methods: A model for PMS was generated from perimenopausal rats with chronic restraint stress (CRS). The effectiveness of traditional Chinese formulas of botanical drugs and a combination of two of the formulas was evaluated based on 1H NMR plasma metabolomic, as well as behavioral and physiological, indicators. To investigate whether the formulas contained ligands that could compensate for the declining level of estrogen, the primary cause of PMS, the ligand-based NMR technique of saturation transfer difference (STD) was employed to detect possible interacting molecules to estrogen receptors in the decoction.Results: Each prescription of the classical Chinese formula moderately attenuated the metabolomic state of the disease model. The best treatment strategy however was to combine two traditional Chinese formulas, each for a different etiology, to adjust the metabolomic state of the disease model to that of rats at a much younger age. In addition, this attenuation of the metabolomics of the disease model was by neither upregulating the estrogen level nor supplementing an estrogenic compound.Conclusion: Treatment of PMS with a traditional Chinese formula of botanical drugs targeting one of the two causes separately could ameliorate the disorder moderately. However, the best outcome was to treat the two causes simultaneously with a decoction that combined ingredients from two traditional prescriptions. The data also implicated a new paradigm for phytotherapy of PMS as the prescribed decoctions contained no interacting compound to modulate the activity of estrogen receptors, in contrast to the treatment strategy of hormone replacement therapy.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

Lan

Liang

et al. 2021

Front. Pharmacol.

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“…The CORT levels in individuals with depression are closely related to their clinical symptoms ( Holloway et al, 2023 ). In a study involving perimenopausal depression rats treated with CSS for 21 days, both CRH and CORT levels significantly increased, indicating that CSS can regulate CRH and CORT levels to restore HPA axis function ( Shengqiang et al, 2015 ). Similarly, in the case of CUMS combined with social isolation-induced depression in rats, CSS exhibited the same antidepressant effects ( Yunhui et al, 2009 ).…”

Section: The Antidepressant Mechanisms Of Cssmentioning

confidence: 99%

Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients

Guo,

Long,

Yao

et al. 2024

Front. Pharmacol.

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Background: Depression is a severe mental disorder that poses a significant threat to both the physical and mental wellbeing of individuals. Currently, there are various methods for treating depression, including traditional Chinese herbal formulations like Chaihu-Shugan-San (CSS), which have shown effective antidepressant effects in both clinical and animal research.Objective: This review aims to provide a comprehensive synthesis of evidence related to CSS, considering both preclinical and clinical studies, to uncover its potential multi-level, multi-pathway, and multi-target mechanisms for treating depression and identify its active ingredients.Methods: A thorough search was conducted in electronic databases, including PubMed, MEDLINE, Web of Science, Google Scholar, CNKI, and Wanfang, using keywords such as “Chaihu Shugan” and “depression” to retrieve relevant literature on CSS and its active ingredients. The review process adhered to the PRISMA guidelines.Results: This review consolidates the mechanisms underlying antidepressant effects of CSS and its active ingredients. It emphasizes its involvement in the regulation of monoaminergic neurotransmitter systems, synaptic plasticity, and the hypothalamic-pituitary-adrenal axis, among other aspects.Conclusion: CSS exerts a pivotal role in treating depression through various pathways, including the monoaminergic neurotransmitter system, the hypothalamic-pituitary-adrenal axis, synaptic plasticity, inflammation, brain-derived neurotrophic factor levels, and the brain-gut axis. This review facilitates a comprehensive understanding of the current state of CSS research, fostering an in-depth exploration of the etiological mechanisms of depression and the potential discovery of novel antidepressant drugs.

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The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

Chen

Liang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Traditional Chinese medicine (TCM) typically attributes the etiopathogenesis of perimenopausal syndrome (PMS) to kidney deficiency in the TCM stratification system for diagnosis. However, the molecular basis of this classical attribution remains to be investigated. Aim of the Study. By unraveling the responses to TCM treatment for kidney deficiency, the metabolomic link between PMS and kidney deficiency can be evaluated for in-depth understanding of the mechanism of TCM treatment and development of better treatment protocols. Materials and Methods. With naturally aged rats as a model for PMS, the metabolomic response to TCM treatment for kidney deficiency was investigated by 1H NMR. Results. 1H NMR metabolomic evidence of plasma samples demonstrates that treatments with two classical TCM prescriptions for kidney deficiency, decoctions of Yougui and Zuogui, result in modulating the metabolic state of the disease model towards that of rats of younger age. Conclusion. The data support the notion that kidney deficiency is responsible, in part at least, for PMS, and the relevant prescriptions are helpful in dampening the changes in the body’s metabolic states to alleviate symptoms of the disorder.

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Effect of Chaihushugan San on expression of the Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase pathway in the hippocampi of perimenopausal rats induced by immobilization stress

Cited by 3 publications

References 26 publications

An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

Potential antidepressant effects of Traditional Chinese botanical drug formula Chaihu-Shugan-San and its active ingredients

The Metabolomic Rationale for Treating Perimenopausal Syndrome as Kidney Deficiency

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