1996
DOI: 10.1016/0928-0987(95)00037-2
|View full text |Cite
|
Sign up to set email alerts
|

Effect of cetirizine on plasma membrane of human eosinophils, neutrophils and platelets: a dose response study

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

1997
1997
2020
2020

Publication Types

Select...
5

Relationship

0
5

Authors

Journals

citations
Cited by 5 publications
(2 citation statements)
references
References 30 publications
0
2
0
Order By: Relevance
“…381 As a matter of fact, loratadine, cetirizine and astemizole are secondgeneration antihistamines that have substituted rstgeneration antihistamines for example diphenhydramine and ketotifen. [382][383][384][385][386][387][388] Loratadine 362 can be produced via various routes. It can be effectively synthesized, based on the formerly reported approaches, 389 starting from the 8-chloro-5,6-dihydro-11H-benzo [5,6]cyclohepta [1,2-b]pyridin-11-one ketone 356, which upon treatment with an appropriate Grignard reagent 355 afforded the respective tertiary carbinol that was subsequently dehydrated in acidic media giving the 8-chlorol-1piperidiylidene derivative 359.…”
Section: Five-membered Heterocyclesmentioning
confidence: 99%
“…381 As a matter of fact, loratadine, cetirizine and astemizole are secondgeneration antihistamines that have substituted rstgeneration antihistamines for example diphenhydramine and ketotifen. [382][383][384][385][386][387][388] Loratadine 362 can be produced via various routes. It can be effectively synthesized, based on the formerly reported approaches, 389 starting from the 8-chloro-5,6-dihydro-11H-benzo [5,6]cyclohepta [1,2-b]pyridin-11-one ketone 356, which upon treatment with an appropriate Grignard reagent 355 afforded the respective tertiary carbinol that was subsequently dehydrated in acidic media giving the 8-chlorol-1piperidiylidene derivative 359.…”
Section: Five-membered Heterocyclesmentioning
confidence: 99%
“…Thus cetirizine could interact with the plasma membranes of eosinophils, neutrophils and platelets or with the cellular cytoskeletons, to induce functional changes in cell response (Kantar et al, 1996). The fast disintegration behavior of conventional cetirizine tablets may result in initial "burst-released" kinetics, permitting the drug to be absorbed very quickly and resulting in high serum concentrations.…”
Section: Introductionmentioning
confidence: 98%