Effect of cetirizine on plasma membrane of human eosinophils, neutrophils and platelets: a dose response study

Kantar, Ahmad; Rihoux, J P; Fiorini, Rosamaria

doi:10.1016/0928-0987(95)00037-2

Cited by 5 publications

(2 citation statements)

References 30 publications

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“…381 As a matter of fact, loratadine, cetirizine and astemizole are secondgeneration antihistamines that have substituted rstgeneration antihistamines for example diphenhydramine and ketotifen. [382][383][384][385][386][387][388] Loratadine 362 can be produced via various routes. It can be effectively synthesized, based on the formerly reported approaches, 389 starting from the 8-chloro-5,6-dihydro-11H-benzo [5,6]cyclohepta [1,2-b]pyridin-11-one ketone 356, which upon treatment with an appropriate Grignard reagent 355 afforded the respective tertiary carbinol that was subsequently dehydrated in acidic media giving the 8-chlorol-1piperidiylidene derivative 359.…”

Section: Five-membered Heterocyclesmentioning

confidence: 99%

Prescribed drugs containing nitrogen heterocycles: an overview

2020

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Section: Five-membered Heterocyclesmentioning

confidence: 99%

Prescribed drugs containing nitrogen heterocycles: an overview

2020

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“…Thus cetirizine could interact with the plasma membranes of eosinophils, neutrophils and platelets or with the cellular cytoskeletons, to induce functional changes in cell response (Kantar et al, 1996). The fast disintegration behavior of conventional cetirizine tablets may result in initial "burst-released" kinetics, permitting the drug to be absorbed very quickly and resulting in high serum concentrations.…”

Section: Introductionmentioning

confidence: 98%

Cetirizine dihydrochloride loaded microparticles design using ionotropic cross-linked chitosan nanoparticles by spray-drying method

Chen

et al. 2010

Arch. Pharm. Res.

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To control the release rate and mask the bitter taste, cetirizine dihydrochloride (CedH) was entrapped within chitosan nanoparticles (CS-NPs) using an ionotropic gelation process, followed by microencapsulation to produce CS matrix microparticles using a spray-drying method. The aqueous colloidal CS-NPs dispersions with a drug encapsulation efficiency (EE) of <15%, were then spray dried to produce a powdered nanoparticles-in-microparticles system with an EE of >70%. The resultant spherical CS microparticles had a smooth surface, were free of organic solvent residue and showed a diameter range of 0.5~5 μm. The in vitro drug release properties of CedH encapsulated microparticles showed an initial burst effect during the first 2 h. Drug release from the matrix CS microparticles could be retarded by the crosslinking agent pentasodium tripolyphosphate or the wall material. The technique of 'ionotropic gelation' combined with 'spray-drying' could be applicable for preparation of CS nanoparticlesin-microparticles drug delivery systems. CS-NPs based microparticles might provide a potential micro-carrier for oral administration of the freely water-soluble drug--CedH.

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Synthesis and antihistamine evaluations of novel loratadine analogues

Wang

Yan

et al. 2011

Bioorganic & Medicinal Chemistry Letters

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Effect of cetirizine on plasma membrane of human eosinophils, neutrophils and platelets: a dose response study

Cited by 5 publications

References 30 publications

Prescribed drugs containing nitrogen heterocycles: an overview

Prescribed drugs containing nitrogen heterocycles: an overview

Cetirizine dihydrochloride loaded microparticles design using ionotropic cross-linked chitosan nanoparticles by spray-drying method

Synthesis and antihistamine evaluations of novel loratadine analogues

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