Effect of cesium radioisotope on humoral immune status in Ukrainian children with clinical symptoms of irritable bowel syndrome related to Chernobyl disaster

Sajjadieh, M.R. Sheikh; Kuznetsova, Larisa; Bojenko, V B

doi:10.1177/0748233710381890

Cited by 6 publications

(4 citation statements)

References 14 publications

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“…At the genus level, despite conflicting findings (showing either an increase or a decrease in each genus), the most consistent finding was the decrease in the relative abundance of the genera Bifidobacterium [18,26,40] and Lactobacillus [18,21,24,28,66] well known for their probiotic effects and shown to be beneficial for the host, being used in clinical practice for gastrointestinal diseases [18,67,68]. Lactobacillus has also been linked to an increase in survival rates after IR exposure [69].…”

Section: Discussionmentioning

confidence: 99%

The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review

Fernandes

Oliveira

Soares

et al. 2023

CIMB

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Background: The gut microbiota is relatively stable; however, various factors can precipitate an imbalance that is known to be associated with various diseases. We aimed to conduct a systematic literature review of studies reporting the effects of ionizing radiation on the composition, richness, and diversity of the gut microbiota of animals. Methods: A systematic literature search was performed in PubMed, EMBASE, and Cochrane library databases. The standard methodologies expected by Cochrane were utilized. Results: We identified 3531 non-duplicated records and selected twenty-nine studies after considering the defined inclusion criteria. The studies were found to be heterogeneous, with significant differences in the chosen populations, methodologies, and outcomes. Overall, we found evidence of an association between ionizing radiation exposure and dysbiosis, with a reduction of microbiota diversity and richness and alterations in the taxonomic composition. Although differences in taxonomic composition varied across studies, Proteobacteria, Verrucomicrobia, Alistipes, and Akkermancia most consistently reported to be relatively more abundant after ionizing radiation exposure, whereas Bacteroidetes, Firmicutes, and Lactobacillus were relatively reduced. Conclusions: This review highlights the effect of ionizing exposure on gut microbiota diversity, richness, and composition. It paves the way for further studies on human subjects regarding gastrointestinal side effects in patients submitted to treatments with ionizing radiation and the development of potential preventive, therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review

Fernandes

Oliveira

Soares

et al. 2023

CIMB

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“…External radiation exposure in Ukraine after the Chernobyl accident appears to be related mostly to changes in the immune status in Ukrainian children (table 2) (1,11,12,36) . Soluble lymphokine derived of T-cell whose main bioactivity is to stimulate the activated T-cell (Th, Ts, and Tc) to reproduce continually and proliferate, is the key mediator in cell and humoral immunity and immune regulation.…”

Section: Importancementioning

confidence: 99%

“…Abdominal pain % 95 - Table 2 Immune status measurement in pa ent with IBS exposed by ionizing radia on (1,11,12,14,36) .…”

Section: Cons Pa On % 31mentioning

confidence: 99%

“…Ionizing radiation is known to increase the development of irritable bowel syndrome (1) by harm the bene.icial members of the gastrointestinal tract .lora (2) (table 3), whereas others have been implicated on the homeostasis of the immune system (1,11,12) , and change in cytokine secretion status and to drive a Th2-biased immune response and may lead this resulting in IBS symptom (14) .…”

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External human exposure and management immune system in pathogenesis of irritable bowel syndrome

Sajjadieh

2016

IJRR

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Challenges in IBD Research: Environmental Triggers

Lewis

Mayer

et al. 2019

Inflammatory Bowel Diseases

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Environmental triggers is part of five focus areas of the Challenges in IBD research document, which also includes preclinical human IBD mechanisms, novel technologies, precision medicine and pragmatic clinical research. The Challenges in IBD research document provides a comprehensive overview of current gaps in inflammatory bowel diseases (IBD) research and delivers actionable approaches to address them. It is the result of a multidisciplinary input from scientists, clinicians, patients, and funders, and represents a valuable resource for patient centric research prioritization. In particular, the environmental triggers section is focused on the main research gaps in elucidating causality of environmental factors in IBD. Research gaps were identified in: 1) epidemiology of exposures; 2) identification of signatures of biological response to exposures; and 3) mechanisms of how environmental exposures drive IBD. To address these gaps, the implementation of longitudinal prospective studies to determine disease evolution and identify sub-clinical changes in response to exposures is proposed. This can help define critical windows of vulnerability and risk prediction. In addition, systems biology analysis and in silico modeling were proposed as approaches to integrate the IBD exposome for the identification of biological signatures of response to exposures, and to develop prediction models of the effects of environmental factors in driving disease activity and response to therapy. This research could lead to identification of biomarkers of exposures and new modalities for therapeutic intervention. Finally, hypothesis-driven mechanistic studies to understand gene-environment interactions and to validate causality of priority factors should be performed to determine how environment influences clinical outcomes.

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Effect of cesium radioisotope on humoral immune status in Ukrainian children with clinical symptoms of irritable bowel syndrome related to Chernobyl disaster

Abstract: Humoral immune status of study groups with clinical symptom of irritable bowel syndrome residing in a contaminated area has changed.

Cited by 6 publications

References 14 publications

The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review

The Effects of Ionizing Radiation on Gut Microbiota: What Can Animal Models Tell Us?—A Systematic Review

External human exposure and management immune system in pathogenesis of irritable bowel syndrome

Challenges in IBD Research: Environmental Triggers

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