Effect of Certain Tablet Formulation Factors on Dissolution Rate of the Active Ingredient II

Influence of Various Starches on Dissolution Rate of Salicylic Acid from Tablets

“…Higuchi et al (17) reported that granulations prepared a t different times may exhibit differences in properties, and Levy ct al. (9) showed that aging of granules significantly changes the dissolution rate of salicylic acid tablets containing starch. Dissolution Methodology-Figures 6-10 show dissolution rates using three different dissolution methods.…”

“…It is widely used as a tablet disintegrator, as a diluent, and as a binder. Levy et al (9) investigated the effect of granule size, compression pressure, and starch concentration on the dissolution rate of salicylic acid from granules prepared by double compression. It was found that the dissolution rate increased with decreasing granule size, with increasing precompression pressure, and with increasing starch content.…”

Analysis of Drug Release from Different Agglomerates Using a Mathmatical Model

“…The model describing the change of concentration over time was based on a modified Noyes-Whitney equation (20) under sink conditions: (1) or expressed as the change of weight over time: (2) where k is the dissolution rate constant, C s is the saturated solution concentration, A is the interfacial area on which dissolution takes place (in this case the surface of all particles is assumed), V is the volume in which the dissolution takes place (volume of the flow-through cell), D is the diffusion coefficient of caffeine, and δ HL is the hydrodynamic layer thickness. A model based only on this equation, where the dissolution rate constant with area and volume factors was the adjustable parameter, was fitted to the experimental data, and the optimal value of the adjustable parameter was estimated by a nonlinear regression analysis in ERA software.…”

“…Since most dosage forms comprise not only the active ingredient but also excipients, the overall rate of API release depends on the properties of both of these components (1)(2)(3)(4). Moreover, it also depends on the arrangement and interaction of individual components of the dosage form, which in turn depend on the dosage form processing history, such as a dry or wet agglomeration process.…”

Effects of interacting variables on the tensile strengths and disintegration times of paracetamol tablets

“…Processing variables such as granulation, temperature, rate of compression and packing fraction achieved can also affect the properties of the tablets. Several workers have studied the separate (Levy et al 1963;Chalmers & Elworthy 1975;Esezobo & Pilpel 1976) and combined (Kurup & Pilpel 1977;Adeyemi & Pilpel 1983;Sanderson et a1 1984) effects of formulation and processing variables with the objective of optimizing the production and therapeutic performance of various tablet formulations.…”