2017
DOI: 10.25258/ijtpr.v9i03.9078
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Effect of Certain Oral Anti Diabetic Drugs on Coagulation Cascade in Diabetes Mellitus

Abstract: Thrombotic events in diabetics contribute for almost 65-80% of cardiovascular events. Diabetes affects the platelet, the coagulation factors and fibrinolytic system leading to a state of hypercoagulation and hypofibrinolysis resulting in to thrombosis. Oral drugs commonly used in management of type II diabetes mellitus are antidiabetics like metformin, PPAR- γ agonist and DPP-4 inhibitor. They rarely produce hypoglycemia. Metformin has been proved to prevent release of mtDNA from arachidonic acid stimulated pl… Show more

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