Effect of cellular ubiquitin levels on the regulation of oxidative stress response and proteasome function via Nrf1

Lee, Donghee; Ryu, Kwon‐Yul

doi:10.1016/j.bbrc.2017.02.105

Cited by 14 publications

(9 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… Table delineating genes in Figure 9 that are associated with the response to oxidative stress ( Duong et al, 2017 ; Jung et al, 2017 ; Lee and Ryu, 2017 ; Peuchant et al, 2017 ; MacLeod et al, 2016 ; Jiang et al, 2016 ; Gorrini et al, 2013 ; Miura et al, 2013 ; Kim et al, 2010 ; Banning et al, 2005 ; Murray et al, 2003 ; Doyle et al, 1999 ). …”

Section: Resultsmentioning

confidence: 99%

Extreme heterogeneity of influenza virus infection in single cells

Russell

Trapnell

Bloom

2018

eLife

225

217

View full text Add to dashboard Cite

Viral infection can dramatically alter a cell’s transcriptome. However, these changes have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA sequencing to examine the transcriptional consequences of influenza virus infection. We find extremely wide cell-to-cell variation in the productivity of viral transcription – viral transcripts comprise less than a percent of total mRNA in many infected cells, but a few cells derive over half their mRNA from virus. Some infected cells fail to express at least one viral gene, but this gene absence only partially explains variation in viral transcriptional load. Despite variation in viral load, the relative abundances of viral mRNAs are fairly consistent across infected cells. Activation of innate immune pathways is rare, but some cellular genes co-vary in abundance with the amount of viral mRNA. Overall, our results highlight the complexity of viral infection at the level of single cells.

show abstract

Section: Resultsmentioning

confidence: 99%

Extreme heterogeneity of influenza virus infection in single cells

Russell

Trapnell

Bloom

2018

eLife

225

217

View full text Add to dashboard Cite

show abstract

“…Surprisingly, proteasomes are needed for Nrf1 activation since Nrf1 produces proteasomes less effectively upon exposure to high concentrations of proteasome inhibitors [13]. In Caenorhabditis elegans , SKN-1 (Skinhead-1; the ortholog of Nrf1/2/3) has a crucial role in response to oxidative stress by promoting the expression of detoxifying genes and the expression of proteasome genes upon proteasome inhibition [14]. It has been shown that for SKN-1 activation following proteasome impairment a peptide-N- glycanase and DDI1, a conserved aspartic protease, are required [15].…”

Section: Oxidative Stressmentioning

confidence: 99%

“…During oxidative stress after As (III) exposure of Ub-deficient N2a neuroblastoma cells, UPS is impaired. This impairment is related to the increase of p65-Nrf1 in the nucleus, a form that competes with Nrf2 and p95-Nrf1, leading to decreased proteasome activity and expression [14].…”

Section: Proteasome Systemmentioning

confidence: 99%

Redox regulation of proteasome function

2017

View full text Add to dashboard Cite

Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS) were initially regarded mainly as metabolic by-products with damaging properties. Over the last decade, our understanding of their role in metabolism was drastically changed and they were recognized as essential mediators in cellular signaling cascades, as well as modulators of biochemical pathways. Proteostasis is highly affected by the various levels of intracellular and extracellular free radicals with either mild or severe outcomes. As part of the proteostatic network, the proteasome system is equally affected by redox alterations. This short review summarizes the effects of oxidative stress on proteasome status while it also recapitulates conditions and processes where redox alterations signal changes to proteasome expression, assembly and function.

show abstract

“…Table delineating genes in Figure 9 that are associated with the response to oxidative stress ( Duong et al, 2017 ; Jung et al, 2017 ; Lee and Ryu, 2017 ; Peuchant et al, 2006 ; MacLeod et al, 2016 ; Jiang et al, 2016 ; Gorrini et al, 2013 ; Miura et al, 2013 ; Kim et al, 2006 ; Banning et al, 2005 ; Murray et al, 2003 ; Doyle et al, 1999 ).…”

Section: Figure 2–figure Supplementmentioning

confidence: 99%

Extreme heterogeneity of influenza virus infection in single cells

Russell

Trapnell

Bloom

2017

Preprint

View full text Add to dashboard Cite

Viral infection can dramatically alter a cell's transcriptome. However, these changes 8 have mostly been studied by bulk measurements on many cells. Here we use single-cell mRNA 9 sequencing to examine the transcriptional consequences of influenza virus infection. We find 10 extremely wide cell-to-cell variation in production of viral gene transcripts -viral transcripts 11 compose less than a percent of total mRNA in many infected cells, but a few cells derive over half 12

show abstract

Effect of cellular ubiquitin levels on the regulation of oxidative stress response and proteasome function via Nrf1

Cited by 14 publications

References 35 publications

Extreme heterogeneity of influenza virus infection in single cells

Extreme heterogeneity of influenza virus infection in single cells

Redox regulation of proteasome function

Extreme heterogeneity of influenza virus infection in single cells

Contact Info

Product

Resources

About