Effect of cellobiose and dietary  soluble fibre on fermentation, growth  performance and health in rabbits

Vega, Ocasio; Enrique, César

doi:10.20868/upm.thesis.50232

Cited by 1 publication

(1 citation statement)

References 130 publications

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“…However, it was noticeable the interaction between cellobiose and soluble fiber detected for rabbit mortality, which was reduced by cellobiose supplementation in LSF-fed rabbits (only for 7.5 g cellobiose/L) but linearly increased in rabbits fed the HSF diet. These results were confirmed in two subsequent experiments (Ocasio-Vega, 2018). They might indicate a negative effect of cellobiose on the intestinal microbiota of HSF-fed rabbits, as the increase in mortality was accompanied with a reduction of cecal total VFA concentrations.…”

Section: Discussionsupporting

confidence: 70%

The effect of cellobiose on the health status of growing rabbits depends on the dietary level of soluble fiber

Ocasio-Vega

Delgado

Abad-Guamán

et al. 2018

Journal of Animal Science

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The aim of this study was to examine whether the combination of dietary soluble fiber and cellobiose exerts a synergistic effect on growth performance, health status, fermentation traits, and immune response in rabbits. Six treatments in a 3 × 2 factorial arrangement were used: 3 cellobiose concentrations in drinking water (0.0, 7.5, and 15.0 g/L) × 2 dietary levels of soluble fiber (84.0 and 130 g/kg DM, for the low soluble fiber [LSF] and high soluble fiber [HSF] diets, respectively). A total of 318 young rabbits (53/treatment) were weaned at 34 d of age and had ad libitum access to feed and water. At 46 d of age, 9 rabbits/treatment were slaughtered and ileal and cecal digesta were collected to analyze VFA profile and the immune response in the cecal appendix mucosa. At 48 d of age, the cellobiose supplementation was withdrawn and the experimental diets were replaced by a standard commercial diet until 61 d of age. From 34 to 48 d of age, there was a linear increase of mortality with the level of cellobiose in the HSF group (0% vs. 17.1%; P = 0.017). In contrast, a quadratic effect of cellobiose level on mortality was observed in the LSF group, the rabbits offered 7.5-cellobiose showing the lowest mortality (5.7% vs. 21.4%; P = 0.030). Cellobiose level had a quadratic effect on ADFI, ADG, and G:F in this period (P ≤ 0.047), with the 7.5-cellobiose groups having the best growth performance. In contrast, only minor changes on these traits were observed from 48 d of age onwards. Cellobiose level influenced quadratically the ileal VFA concentrations (P = 0.014), showing the maximal value in the 7.5-cellobiose groups. In rabbits fed 7.5-cellobiose-LSF, a change of acetate to propionate, butyrate, and valerate was observed in the ileum. Increasing cellobiose levels reduced linearly cecal VFA concentrations in HSF fed rabbits, but no effect was detected in LSF groups (P = 0.046). The level of soluble fiber increased VFA concentrations in both the ileum (by 22%; P < 0.001), and the cecum (by 11%; P = 0.005). The relative gene expression of IL-6, IL-10, TNF-α, iNOS, MUC-1, and toll-like receptors (TLR-2 and TLR-4) in the cecal appendix increased linear and quadratically with increasing levels of cellobiose (P ≤ 0.063). In conclusion, in rabbits fed LSF diets, a dose of 7.5 g cellobiose/L drinking water would be recommended, whereas these levels of cellobiose supplementation should be avoided in rabbits fed HSF diets.

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Section: Discussionsupporting

confidence: 70%